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Can EUS elastography help distinguish benign from malignant tissue?
April 15, 2009A major limitation of endoscopic ultrasound (EUS) examination is its limited capacity to determine the exact nature of a lesion. The differential diagnosis between benign and malignant lymph nodes and focal pancreatic masses based on the EUS appearance is difficult and frequently requires EUS-guided fine needle aspiration (EUS-FNA) for confirmation of malignancy. Elastography has recently been presented as a novel technique that can be applied during ultrasound (US) examination to assess and measure tissue elasticity. Knowing that malignant tissues are generally harder than normal surrounding tissue, elastography might provide interesting clinical information to help distinguish benign from malignant tissue based on their specific tissue consistency.
A research article to be published on April 7, 2009 in the World Journal of Gastroenterology addresses this question. A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass or lymph node. Knowing that malignant tissues are generally harder than normal surrounding tissue, elastography might provide interesting clinical information to help distinguish benign from malignant tissue based on their specific tissue consistency.
The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%, respectively, compared to 92.3% and 68.9%, respectively, for the conventional B-mode images. The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%, respectively, compared to 78.6% and 50.0%, respectively, for the B-mode images. The kappa coefficient is 0.785 for the pancreatic masses and 0.657 for the lymph nodes.
EUS elastography is superior compared to conventional B-mode imaging and appears able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivi-ty, specificity and accuracy. It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes.
World Journal of Gastroenterology
EUS elastography is superior compared to conventional B-mode imaging and appears able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivi-ty, specificity and accuracy. It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes.
World Journal of Gastroenterology
Elastography Current Events and Elastography News RSSProbe position may change results in liver stiffness measurements in transient elastography
A major clinical challenge is to find the best method to evaluate and to manage the increasing numbers of patients with chronic liver disease. Liver biopsy, due to its risks and limitations, is no longer considered mandatory as the first-line indicator of liver injury, and several markers have been developed as non-invasive alternatives.
New Women's Imaging Technique Allows for a More Accurate Diagnosis of Breast Cancer
Breast elastography allows physicians to give a more accurate diagnosis of breast cancer, according to a study performed at Singapore General Hospital in Singapore.
Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease
A new study shows that an imaging technology developed by Mayo Clinic researchers can identify liver fibrosis with high accuracy and help eliminate the need for liver biopsies. Liver fibrosis is a common condition that can lead to incurable cirrhosis if not treated in time.
Noninvasive test accurately identifies advanced liver disease without biopsy
Non-invasively measuring liver stiffness with transient elastography accurately diagnoses patients with late-stage liver disease, reports a new study in Clinical Gastroenterology and Hepatology, the official journal of the American Gastroenterological Association (AGA) Institute.
MRE could provide a definitive diagnosis for people with muscle pain, Mayo Clinic study shows
An estimated nine million men and women in the United States live with myofascial pain syndrome, a condition marked by pain that permeates muscles in the neck, back and shoulders.
Noninvasive tests for cirrhosis may help to avoid liver biopsy
Newer ultrasound and magnetic resonance (MR) imaging tests yield encouraging initial results in diagnosing fibrosis (scarring) and cirrhosis of the liver, according to three studies in the October issue of the journal Clinical Gastroenterology and Hepatology.
New Mayo Clinic MRI technology enables noninvasive liver diagnoses
Two recent Mayo Clinic studies have found that magnetic resonance elastography (MRE), a new imaging technique invented at Mayo Clinic, is an accurate tool for non-invasive diagnosis of liver diseases.
Liver diagnosis breakthrough with Mayo Clinic MRI development
Mayo Clinic researchers have developed a new technique for using magnetic resonance imaging (MRI) to accurately measure the hardness or elasticity of the liver. First tests show this technology - called MR Elastography (MRE) - holds great promise for detecting liver fibrosis, a common condition that can lead to incurable cirrhosis if not treated in time.
More Elastography Current Events and Elastography News Articles
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Displacement Estimation Analyses: Reconstructive Ultrasound Elastography using Finite-Amplitude Deformations by Walaa Khaled (Author) Die quantitative Abbildung mechanischer Eigenschaften des menschlichenGewebes ist Gegenstand aktueller Forschung auf dem Gebiet derUltraschalldiagnostik. Eine Ver¿nderung dieser Eigenschaften ist in vielenF¿llen pathologischer Art, insbesondere Tumoren stellen sich h¿ufig alsGewebeverh¿rtungen dar. Dabei ist zu beachten, dasskonventionelle bildgebende Verfahren f¿r die medizinische Diagnostik(Computertomographie, Magnetresonanztomographie und Ultraschall) keinedirekte Messung der mechanischen Eigenschaften erm¿glichen. Im Rahmen dieser Arbeit wird die Ermittlung der Materialverteilung desGewebes als ein inverses Problem interpretiert und mit Hilfe derrekonstruktiven Ultraschall-Elastographie quantitativ durchgef¿hrt. DieVerschiebung im Innern des Gewebes, die durch eine ¿u¿ere... |
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Elastography: Webster's Timeline History, 1983 - 2007 by Icon Group International (Author) Webster's bibliographic and event-based timelines are comprehensive in scope, covering virtually all topics, geographic locations and people. They do so from a linguistic point of view, and in the case of this book, the focus is on "Elastography," including when used in literature (e.g. all authors that might have Elastography in their name). As such, this book represents the largest compilation of timeline events associated with Elastography when it is used in proper noun form. Webster's timelines cover bibliographic citations, patented inventions, as well as non-conventional and alternative meanings which capture ambiguities in usage. These furthermore cover all parts of speech (possessive, institutional usage, geographic usage) and contexts, including pop culture, the arts, social... |
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Ultrasonic elastography of porcine coronaries: High frequency ultrasonic elastography measurements of the mechanical properties of porcine coronary vessel walls by Veerdhaval Mahajan (Author) Coronary heart diseases are a significant cause of death among both men and women in the industrialized world. Thus finding ways to detect factors, which cause coronary heart diseases, is a worthy challenge for researchers. Ultrasound elastography system (50MHz) for measuring mechanical properties of arteries was developed as part of this thesis. Ability to discriminate between various tissue types was demonstrated using fresh and modified porcine coronary arteries, which closely models the plaque in human atherosclerosis. Elastographic measurements agreed well with uniaxial mechanical testing over a range of compression moduli. |
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