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Building the lymphatic drainage system
April 27, 2009Our bodies' tissues need continuous irrigation and drainage. Blood vessels feeding the tissues bring in the fluids, and drainage occurs via the lymphatic system. While much is known about how blood vessels are built, the same was not true for lymph vessels. Now though, Norrmén et al. have identified two of the lead engineers that direct drainage construction in the mouse embryo.
The engineers are the transcription factors, Foxc2 and NFATc1. Foxc2 had been implicated in lymph vessel development already, but Norrmén and colleagues have now found that the factor specifically regulates a late stage of lymph development when large, valve-containing vessels arise from more primitive capillaries. The study will be published online April 27 (www.jcb.org) and will appear in the May 4 print issue of the Journal of Cell Biology.
Foxc2 built the lymph vessel valves with the help of NFATc1, which was a known heart valve engineer. Norrmén and colleagues also showed that Foxc2 and NFATc1 physically interact and that many DNA binding sites for the two transcription factors are closely linked. This latter finding generated a long list of target genes that might be controlled by the two factors.
The team now plans to investigate these targets as well as to work out the upstream molecular pathways controlling Foxc2 and NFATc1. Whatever the mechanisms, if the team can show that Foxc2 and NFATc1 also prompt lymph vessel regeneration in adults, boosting these factors could help patients with lymph drainage problems - including those that have suffered extensive tissue injuries, or have had lymph nodes removed as part of cancer treatment.
Rockefeller University Press
The team now plans to investigate these targets as well as to work out the upstream molecular pathways controlling Foxc2 and NFATc1. Whatever the mechanisms, if the team can show that Foxc2 and NFATc1 also prompt lymph vessel regeneration in adults, boosting these factors could help patients with lymph drainage problems - including those that have suffered extensive tissue injuries, or have had lymph nodes removed as part of cancer treatment.
Rockefeller University Press
Lymphatic System Current Events and Lymphatic System News RSSDiscovery offers potential new pancreatic cancer treatment
Tiny particles that can carry drugs and target cancer cells may offer treatment hope for those suffering with pancreatic cancer. New research to be presented in November at the American Association of Pharmaceutical Scientists (AAPS) Annual Meeting in Los Angeles reveals that tumor-penetrating microparticles (TPM) have been specifically designed to break through hard-to-infiltrate barriers and deliver drugs more effectively and efficiently than the standard form of chemotherapy such as those injected through a vein.
MDC scientists show how hematopoietic stem cell development is regulated
During cell division, whether hematopoietic stem cells (HSCs) will develop into new stem cells (self-renewal) or differentiate into other blood cells depends on a chemical process called DNA methylation.
Experimental drug lets B cells live and lymphoma cells die
An investigative drug deprived non-Hodgkin lymphoma cells of their ability to survive too long and multiply too fast, according to an early study published recently in the journal Experimental Hematology.
New 'adjuvant' could hold future of vaccine development
Scientists at Oregon State University have developed a new "adjuvant" that could allow the creation of important new vaccines, possibly become a universal vaccine carrier and help medical experts tackle many diseases more effectively.
Colorectal cancer
Previously, only a few genes had been associated with the formation of metastases in colorectal cancer. Now, researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch and Charité - University Medicine Berlin, Germany, have identified 115 genes that are disregulated both in the primary tumor and in its metastases.
New technique may help detect potential breast cancer spread
A new phase III clinical trial of early stage breast cancer patients has shown that a molecule designed to home in on nearby lymph nodes is just as accurate as current techniques, but faster, more specific and easier to use.
Ambati study published in PNAS
The side effects of an experimental "gene-silencing" treatment that is currently being investigated for a variety of diseases are even more wide-ranging than previously discovered, according to a study by a University of Kentucky researcher.
A new theoretical model of tumor growth and metastasis based on differences in tissue pressure
The HFSP Journal, the interdisciplinary journal for scientists conducting high quality, innovative research at the interface between biology and the physical sciences is pleased to announce that the latest article modelling of tumor growth and metastasis.
Big-Hearted Fish Reveals Genetic Underpinnings of Enigmatic Cardiovascular Condition, According to Penn Study
Researchers at the University of Pennsylvania School of Medicine have unlocked the mystery of a puzzling human disease and gained insight into cardiovascular development, all thanks to a big-hearted fish.
Angiogenesis linked to poor survival in patients with rare type of ovarian cancer
Researchers from The University of Texas M. D. Anderson Cancer Center have found that increased angiogenesis, or blood vessel formation, and vascular endothelial growth factor expression are associated with poor survival in women with sex cord-stromal ovarian tumors.
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Your Key to Good Health: Unlocking the Power of Your Lymphatic System by Elaine Hruska (Author) Author Elaine Hruska uses her 30 years of experience with the Cayce health readings to show you how the lymph functions, what conditions threaten the health of this system, and what you can do to maintain good health throughout your lymph and the rest of your body: Lymph 101 Know your nodes! Get the basics on the lymphatic system Lymph and Cayce What did Cayce say about your lymph? Lymph and Health What conditions are linked to the lymphatic system? The Wonders of Lymph Keeping the lymph healthy for a strong, vibrant body Pick up a copy of Your Key to Good Health, and you ll be on your way to better understanding the lymphatic system as the key to your body s good health. |
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Lymphatic System Laminated Reference Guide (Medical Series) by Inc. Barcharts (Compiler) Complete, labeled illustrations of the parts of the lymphatic system in nine different views and sections From pre-teen to pre-med, this chart is loaded with beautifully illustrated diagrams clearly and concisely labeled for easy identification Illustrations by award-winning medical illustrator Vince Perez Chart includes detailed diagrams of: · head & neck · arm axilla & thorax · nodes & vessels · thoracic duct · deep abdominal & inguinal nodes · large intestine · stomach & pancreas · heart & lungs |
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The Lymphatic System (Human Body Systems) by Julie McDowell (Author), Michael Windelspecht (Author) Beginning with an exploration of the chemicals and cells of the lymphatic system, this volume of the Encyclopedia of the Human Body discusses the various components of the lymphatic system and how they work together to initiate the immune response, act as a secondary circulatory system, and transport select nutrients from the digestive system to the circulatory system. The lymph system, including lymph nodes and lymphatic circulation are explored and lymphatic functions of the spleen, appendix, and tonsils are discussed. The history of the research on the lymphatic system is presented and the future of research in this field is considered. Current controversies and dilemmas of scientists performing this research are explored. Lymphatic system disorders and diseases, and their symptoms and... |
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The anatomy of the lymphatic system by Edward Emanuel Klein (Author) Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: 31 CHAPTER III. THE LYMPHATIC VESSELS OF THE SEROUS MEMBRANES. a. Lymphatics of the Omentum and the Pleura Mediastini. In the rabbit's omentum the lymphatics are easily demonstrated. Following the above-mentioned method, it is necessary only to pencil in situ the surface of the fresh omenlum and then to stain it in silver. Different portions of the omentum are differently circumstanced as regards lymphatics. In the neighbourhood of the greater curvature of the stomach, and in the portion of omentum covering its pyloric end, there occurs a rich network of lymphatics : they are related to the... |
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The Lymphatic System chart by Various (Author) The Lymphatic System chart lays out the structure of the system that helps with the body?s defenses against infection and disease. The chart shows the overall system of drainage in the body, the structure of lymph nodes and lymph vessels, and the formation of lymphocytes. |
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Secrets of the Lymphatic System, The Fountain of Youth Is WIthin Us by Dr.Tapzyana B. Thomas (Author), Erin Hepprin (Illustrator), Dr. Paul l L Warner (Illustrator) Every Disease Known To Man Is Caused By Blockages In the Lymphatic System. This book reveals the truth of this statement with unknown facts and secrets that will surprise the reader. The Lymphy charactor, illustrates the Lymphatic System from Radiant Health to Death, plus all states of deterioration and Lymphatic blockage sources. The cause of Cancer is revealed with illustrations and the Formulas for Life and Death. This book clearly and powerfully demonstrates how the reader can take back the power of their health and well being. The Fountain of Youth is revealed and how to activate it along with, how our thoughts, feelings and observations create our health and how this occurs in simple plain easy to understand language. The reader will be able to know what state their... |
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Standard Deviants School - Anatomy, Program 6 - The Lymphatic and Respiratory Systems (Classroom Edition) Starring: Standard Deviants School Do you long to better understand your lungs? You'll learn all about the amazing lymphatic and respiratory systems. First we'll cover the lymphatic system and all of its wonders. Then we'll tackle the respiratory system, where you'll see how our bodies obtain oxygen from the air and distribute it throughout our bodies. |
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How to Flush Toxins From Your Lymphatic System Healthy Living Secrets (Primary Contributor) |
![Saunders Physical Examination & Health Assessment: Cardiovascular System: Peripheral Vascular System And Lymphatic System Video [VHS]](http://ecx.images-amazon.com/images/I/51%2BTD4c70PL._SL160_.jpg) |
Saunders Physical Examination & Health Assessment: Cardiovascular System: Peripheral Vascular System And Lymphatic System Video [VHS] Starring: Saunders |
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Lymphatic System Anatomical Chart Laminated-8937PL1.5 by Anatomical Chart Company |
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