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Understanding a target of quinoline drugs
April 28, 2009The full details about the molecules and mechanisms that underlie the development of autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, remain to be discovered. One compound that may have a role in alleviating these conditions is quinoline-3-carboxamide, which is currently being tested in various clinical trials. In this week's PLoS Biology, researchers from Lund University, Sweden, the University of Munster in Germany, and the company Active Biotech AB, identify a molecular target for quinoline compounds.
This study shows that quinoline compounds bind to a molecule called S100A9, which is expressed in some white blood cells that are involved in the regulation of immune responses. Furthermore, S100A9 interacts with two known pro-inflammatory receptors (Toll like receptor 4 (TLR4) and receptor of advanced glycation end products (RAGE), and this interaction is inhibited by quinoline compounds.
The published data describe a new mechanism whereby S100A9 can promote pro-inflammation at early stages of immune activation. These findings may lead to an increased understanding of the early steps in the development of autoimmune disease.
Three of Active Biotech's projects (laquinimod, 57-57 and TASQ) belong to the quinoline chemical class of compounds.
Public Library of Science
Three of Active Biotech's projects (laquinimod, 57-57 and TASQ) belong to the quinoline chemical class of compounds.
Public Library of Science
More Quinoline Compounds Current Events and Quinoline Compounds News Articles
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The Chemistry of Heterocyclic Compounds, Quinolines (Chemistry of Heterocyclic Compounds: A Series Of Monographs) (Part 2, Volume 32) by Gurnos Jones (Editor) |
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The Chemistry of Heterocyclic Compounds, Quinolines (Chemistry of Heterocyclic Compounds: A Series Of Monographs) (Part 3, Volume 32) by John V. Greenhill (Editor) The third part of Volume 32 deals with two major groups of quinoline compounds, the aldehydes and the ketones. The treatment differs from that adopted in previous parts, as the material is arranged entirely in the form of information on properties, but the chapters make no pretence of recording all information on the chemical and physical properties of quinoline aldehydes or ketones. Nevertheless, in common with Parts One and Two, all references to quinoline aldehydes and ketones are included as far as possible. | |
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The 2007 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Quinoline or Isoquinoline Ring-System Not Further Fused in United States by Philip M. Parker (Author) On the demand side, exporters and strategic planners focusing on heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused in United States face a number of questions. Which countries are supplying heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused to United States? How important is United States compared to others in terms of the entire global and regional market? How much do the imports of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused vary from one country of origin to another in United States? On the supply side, United States also exports heterocyclic compounds... |
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The 2007 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Quinoline or Isoquinoline Ring-System Not Further Fused in China by Philip M. Parker (Author) On the demand side, exporters and strategic planners focusing on heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused in China face a number of questions. Which countries are supplying heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused to China? How important is China compared to others in terms of the entire global and regional market? How much do the imports of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused vary from one country of origin to another in China? On the supply side, China also exports heterocyclic compounds with nitrogen hetero-atom(s) only,... |
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The 2007 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Quinoline or Isoquinoline Ring-System Not Further Fused in India by Philip M. Parker (Author) On the demand side, exporters and strategic planners focusing on heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused in India face a number of questions. Which countries are supplying heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused to India? How important is India compared to others in terms of the entire global and regional market? How much do the imports of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused vary from one country of origin to another in India? On the supply side, India also exports heterocyclic compounds with nitrogen hetero-atom(s) only,... |
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Heterocyclic Compounds, Voulme 4 : Quinoline, Isoquinoline, and Thier Benzo Derivatives by Robert C. Elderfield (Author) | |
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Heterocyclic Compounds, Vol. 4 Quinoline, Isoquinoline, and Their Benzo Derivati by Robert C. Elderfield (Author) | |
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The 2009 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Quinoline or Isoquinoline Ring-System Not Further Fused in Latin America by Icon Group International (Author) On the demand side, exporters and strategic planners approaching the market in Latin America face a number of questions. Which countries are supplying heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused to Latin America? What is the dollar value of these imports? How much do the imports of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused vary from one country to another in Latin America? Do exporters serving the market in Latin America have similar market shares across the importing countries? On the supply side, Latin America also sells to the international market of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a... |
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The 2009 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Quinoline or Isoquinoline Ring-System Not Further Fused in Asia by Icon Group International (Author) On the demand side, exporters and strategic planners approaching the market in Asia face a number of questions. Which countries are supplying heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused to Asia? What is the dollar value of these imports? How much do the imports of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused vary from one country to another in Asia? Do exporters serving the market in Asia have similar market shares across the importing countries? On the supply side, Asia also sells to the international market of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not... |
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The 2009 Import and Export Market for Heterocyclic Compounds with Nitrogen Hetero-Atom(s) Only, Containing a Quinoline or Isoquinoline Ring-System Not Further Fused in North America & the Caribbean by Icon Group International (Author) On the demand side, exporters and strategic planners approaching the market in North America & the Caribbean face a number of questions. Which countries are supplying heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused to North America & the Caribbean? What is the dollar value of these imports? How much do the imports of heterocyclic compounds with nitrogen hetero-atom(s) only, containing a quinoline or isoquinoline ring-system not further fused vary from one country to another in North America & the Caribbean? Do exporters serving the market in North America & the Caribbean have similar market shares across the importing countries? On the supply side, North America & the Caribbean also sells to the international... |
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