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Universal flu vaccine holds promise
April 28, 2009Study results will be presented at infectious diseases meeting on monday
ST. LOUIS -- An influenza vaccine that protects against death and serious complications from different strains of flu is a little closer to reality, Saint Louis University vaccine researchers have found.
"This is a significant first step in developing a universal vaccine to help protect against pandemic influenza," said Robert Belshe, M.D., director of the Saint Louis University Center for Vaccine Development.
Belshe, the lead researcher who studied a vaccine made with proteins from strains of influenza viruses A and B, presents his findings on April 27 at the National Foundation for Infectious Disease Conference for Vaccine Research in Baltimore.
Currently drug companies manufacture a different flu vaccine each year to match the strains of influenza that researchers predict will circulate. Adding a universal influenza vaccine to a seasonal vaccine would help improve protection against strains of influenza as they change each year.
"Novel vaccines, capable of inducing long-lasting, broad immunity against divergent strains, including potential pandemic viruses, are highly desirable," Belshe said.
In the study, 377 healthy adults received three injections of a universal influenza vaccine, known as Bivalent Influenza Peptide Conjugate Vaccine (BIPCV), over a six month period.
Researchers found that a low dose of the vaccine is well tolerated and safe, Belshe said. It addition, the low dose vaccine evoked an immune response - high antibody titers - that is similar to levels associated with protecting small animals infected with influenza from serious disease and death. More testing is needed, Belshe added.
The research also is significant in light of the search for a vaccine to protect against a deadly influenza pandemic, which is a global outbreak of the disease that spreads quickly with lethal consequences.
Saint Louis University
Belshe, the lead researcher who studied a vaccine made with proteins from strains of influenza viruses A and B, presents his findings on April 27 at the National Foundation for Infectious Disease Conference for Vaccine Research in Baltimore.
Currently drug companies manufacture a different flu vaccine each year to match the strains of influenza that researchers predict will circulate. Adding a universal influenza vaccine to a seasonal vaccine would help improve protection against strains of influenza as they change each year.
"Novel vaccines, capable of inducing long-lasting, broad immunity against divergent strains, including potential pandemic viruses, are highly desirable," Belshe said.
In the study, 377 healthy adults received three injections of a universal influenza vaccine, known as Bivalent Influenza Peptide Conjugate Vaccine (BIPCV), over a six month period.
Researchers found that a low dose of the vaccine is well tolerated and safe, Belshe said. It addition, the low dose vaccine evoked an immune response - high antibody titers - that is similar to levels associated with protecting small animals infected with influenza from serious disease and death. More testing is needed, Belshe added.
The research also is significant in light of the search for a vaccine to protect against a deadly influenza pandemic, which is a global outbreak of the disease that spreads quickly with lethal consequences.
Saint Louis University
Influenza Vaccine Current Events and Influenza Vaccine News RSSWorksite wellness programs may reduce employee absenteeism
Emory University Rollins School of Public Health researchers will present Nov. 11 on a range of topics at the American Public Health Association's annual meeting in Philadelphia, including a study that found reduced absenteeism among employees participating in a large-scale worksite wellness program.
Initial Results Show Pregnant Women Mount Strong Immune Response To One Dose of 2009 H1N1 Flu Vaccine
Healthy pregnant women mount a robust immune response following just one dose of 2009 H1N1 influenza vaccine, according to initial results from an ongoing clinical trial sponsored by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.
Flu vaccine given to women during pregnancy keeps infants out of the hospital
Infants born to women who received influenza vaccine during pregnancy were hospitalized at a lower rate than infants born to unvaccinated mothers.
Flu shots not to be sneezed at
Two in five at-risk American adults who would benefit from vaccination against seasonal flu are missing out on the protective shots because they believe they do not need them and are not inclined to be vaccinated.
NIH launches 2009 H1N1 influenza vaccine trials in HIV-infected pregnant women
The first clinical trials to test whether the 2009 H1N1 influenza vaccine can safely elicit a protective immune response in pregnant women launched yesterday, and a trial to conduct the same test in HIV-infected children and youth will begin next week.
NIH prepares to launch 2009 H1N1 influenza vaccine trial in people with asthma
The National Institutes of Health is preparing to launch the first government-sponsored clinical trial to determine what dose of the 2009 H1N1 influenza vaccine is needed to induce a protective immune response in people with asthma, especially those with severe disease.
Early results: In children, 2009 H1N1 influenza vaccine works like seasonal flu vaccine
Early results from a trial testing a 2009 H1N1 influenza vaccine in children look promising, according to the trial sponsor, the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Early results from clinical trials of 2009 H1N1 influenza vaccines in healthy adults
We are encouraged by reports that are now emerging from various clinical trials of 2009 H1N1 influenza vaccines, conducted by various vaccine manufacturers.
GEN reports on efforts to quickly develop swine flu vaccine
Scientists around the world are accelerating their efforts to develop a vaccine against the H1N1 influenza virus (Swine flu) as rapidly as possible, reports Genetic Engineering & Biotechnology News (GEN).
Flu virus foiled again
Researchers at The Scripps Research Institute in La Jolla, California, supported in part by the National Institutes of Health, have identified a common Achilles' heel in a wide range of seasonal and pandemic influenza A viruses.
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