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NASA's electronic nose may provide neurosurgeons with a new weapon against brain cancer
April 30, 2009An unlikely multidisciplinary scientific collaboration has discovered that an electronic nose developed for air quality monitoring on Space Shuttle Endeavour can also be used to detect odour differences in normal and cancerous brain cells. The results of the pilot study open up new possibilities for neurosurgeons in the fight against brain cancer.
Neurosurgeons from the City of Hope Cancer Center, along with scientists from the Brain Mapping Foundation in West Hollywood and the Jet Propulsion Laboratory (JPL) in Pasadena, used NASA's electronic nose to investigate the role of cellular odours in cellular trafficking, brain cancer metastasis, stem cell migration, and the potential of the device to be used for intraoperative imaging.
The electronic nose, which is to be installed on the International Space Station in order to automatically monitor the station's air, can detect contaminants within a range of one to approximately 10,000 parts per million. In a series of experiments, the Brain Mapping Foundation used NASA's electronic nose to sniff brain cancer cells and cells in other organs. Their data demonstrates that the electronic nose can sense differences in odour from normal versus cancerous cells. These experiments will help pave the way for more sophisticated biochemical analysis and experimentation.
Babak Kateb, lead author of the paper, Chairman and Scientific Director of the Brain Mapping Foundation, said: "This pilot study lays the groundwork for future research that may help us to better understand cellular trafficking, contribute to designing better approaches for the detection and differentiation of brain cancer, and understand the pathophysiology of intracranial gliomas."
The results of the pilot study are set to be published in an IBMISPS-NeuroImage special issue in July, and presented at the 6th Annual World Congress for Brain Mapping & Image Guided Therapy at Harvard Medical School, August 26-29, 2009 (www.ibmisps-worldcongress.org).
The Brain Mapping and Image Guided Therapy World Congress, co-hosted by Elsevier, aims to break boundaries and explore break-through research in neuroscience, technology, medicine and healthcare policy.
A multidisciplinary forum, the Congress attracts prominent scientists, surgeons, engineers, rehabilitation medicine physicians, neurologists, neurosurgeons, radiologists, psychiatrists, cardiologists, pulmonologists, bioethicists, policy makers, government officials, neuroeconomists, physicists, graphic designers, computer scientists, healthcare professionals and executives, students, post-doctorates, residents, and fellows.
The Congress is also supported by the US Army Telemedicine Advance Telecommunication Research Center (TATRC), Defence Veteran Traumatic Brain Injury Center (DVBIC) and industry leaders such as Medtronic and BrainLab.
For more information about session topics, speakers, registration, travel and lodging, please visit: www.ibmisps-worldcongress.org
Elsevier
Babak Kateb, lead author of the paper, Chairman and Scientific Director of the Brain Mapping Foundation, said: "This pilot study lays the groundwork for future research that may help us to better understand cellular trafficking, contribute to designing better approaches for the detection and differentiation of brain cancer, and understand the pathophysiology of intracranial gliomas."
The results of the pilot study are set to be published in an IBMISPS-NeuroImage special issue in July, and presented at the 6th Annual World Congress for Brain Mapping & Image Guided Therapy at Harvard Medical School, August 26-29, 2009 (www.ibmisps-worldcongress.org).
The Brain Mapping and Image Guided Therapy World Congress, co-hosted by Elsevier, aims to break boundaries and explore break-through research in neuroscience, technology, medicine and healthcare policy.
A multidisciplinary forum, the Congress attracts prominent scientists, surgeons, engineers, rehabilitation medicine physicians, neurologists, neurosurgeons, radiologists, psychiatrists, cardiologists, pulmonologists, bioethicists, policy makers, government officials, neuroeconomists, physicists, graphic designers, computer scientists, healthcare professionals and executives, students, post-doctorates, residents, and fellows.
The Congress is also supported by the US Army Telemedicine Advance Telecommunication Research Center (TATRC), Defence Veteran Traumatic Brain Injury Center (DVBIC) and industry leaders such as Medtronic and BrainLab.
For more information about session topics, speakers, registration, travel and lodging, please visit: www.ibmisps-worldcongress.org
Elsevier
Brain Cancer Current Events and Brain Cancer News RSSMagnetic nanoparticles to simultaneously diagnose, monitor and treat
Whether it's magnetic nanoparticles (mNPs) giving an army of 'therapeutically armed' white blood cells direction to invade a deadly tumour's territory, or the use of mNPs to target specific nerve channels and induce nerve-led behaviour (such as the life-dependant thumping of our hearts), mNPs have come a long way in the past decade.
Angiochem crosses BBB, shows safety, efficacy in phase 1/2 brain cancer studies
Angiochem, Inc. a clinical-stage biotechnology company developing drugs that are uniquely capable of crossing the blood-brain barrier to treat brain diseases, announced today that its lead drug candidate, ANG1005, has demonstrated a favorable safety and efficacy profile in more than 100 patients with brain cancer from two separate Phase 1 /2 clinical studies in patients with progressive gliomas, including recurrent glioblastoma, and in patients with progressive brain metastases.
Toward a nanomedicine for brain cancer
In an advance toward better treatments for the most serious form of brain cancer, scientists in Illinois are reporting development of the first nanoparticles that seek out and destroy brain cancer cells without damaging nearby healthy cells.
UM scientists pinpoint critical molecule to celiac disease, possibly other autoimmune disorders
It was nine years ago that University of Maryland School of Medicine researchers discovered that a mysterious human protein called zonulin played a critical role in celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes.
Experts warn over health check brain scans
A new study has voiced concern about the growing market for brain screening tests, which people can buy as part of a general health MOT.
Avastin dramatically improves response, survival in deadly recurrrent glioblastomas
The targeted therapy Avastin, alone and in combination with the chemotherapy drug CPT-11, significantly increased response rates, progression-free survival times and survival rates in patients with a deadly form of brain cancer that had recurred.
Computational Process Zeroes in on Top Genetic Cancer Suspects
Johns Hopkins engineers have devised innovative computer software that can sift through hundreds of genetic mutations and highlight the DNA changes that are most likely to promote cancer.
NIH study reveals new genetic culprit in deadly skin cancer
Drawing on the power of DNA sequencing, National Institutes of Health researchers have identified a new group of genetic mutations involved in the deadliest form of skin cancer, melanoma.
NIH researchers identify key factor that stimulates brain cancer cells to spread
Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM).
Anti-psychotic drugs could help fight cancer
The observation that people taking medication for schizophrenia have lower cancer rates than other people has prompted new research revealing that anti-psychotic drugs could help treat some major cancers.
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