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New insight into Alzheimer's disease pathology
May 04, 2009An Alzheimer's-related protein helps form and maintain nerve cell connections, according to a study published in the May 4 print issue of the Journal of Cell Biology and online at www.jcb.org.
The protein, called presenilin, is mutated in many cases of inherited Alzheimer's disease. Although the inherited form of Alzheimer's is relatively rare, researchers hope that by studying the function of the protein, they will glean insights into the pathology of the more common non-inherited form of the disease. Presenilin is known to form part of an enzyme complex called gamma secretase, which sits in nerve cell membranes and chops up other proteins. Inoue et al have found a new target of gamma secretase, a protein called EphA4.
The product of EphA4 cleavage drove the formation and maintenance of dendritic spines - the nerve cell's receivers for transmitted signals. These results fit with a growing hypothesis that failing nerve transmission might be an early step in the pathology of Alzheimer's.
Rockefeller University Press
Rockefeller University Press
Disease Pathology Current Events and Disease Pathology News RSSScientists remove amyloid plaques from brains of live animals with Alzheimer's disease
A breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's Disease that actually removes amyloid plaques-considered a hallmark of the disease-from patients' brains.
August 10, 2009 New Class of Compounds Discovered for Potential Alzheimer's Disease Drug, Penn Study Finds
A new class of molecules capable of blocking the formation of specific protein clumps that are believed to contribute to the dementia of Alzheimer's disease (AD) patients has been discovered by researchers at the University of Pennsylvania School of Medicine.
Patient-derived induced stem cells retain disease traits
hen neurons started dying in Clive Svendsen's lab dishes, he couldn't have been more pleased. The dying cells - the same type lost in patients with the devastating neurological disease spinal muscular atrophy - confirmed that the University of Wisconsin-Madison stem cell biologist had recreated the hallmarks of a genetic disorder in the lab, using stem cells derived from a patient.
Gene therapy corrects sickle cell disease in laboratory study
Using a harmless virus to insert a corrective gene into mouse blood cells, scientists at St. Jude Children's Research Hospital have alleviated sickle cell disease pathology.
International TGen-led team finds link between brain protein and Alzheimer's disease
Investigators at the Translational Genomics Research Institute (TGen) today announced a link between the brain protein KIBRA and Alzheimer's disease, a discovery that could lead to promising new treatments for this memory-robbing disorder.
Europe-wide investment in lipid research will help tackle disease, says new report
Leading scientists today called for Europe to invest more funds into the study of lipids - the 'fatty' molecules that play a crucial role in the function of human cells and which are implicated in a range of diseases from obesity and diabetes to Alzheimer's.
Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates
Researchers at the Yerkes National Primate Research Center, Emory University, have discovered the first conclusive evidence of Alzheimer's-like neurofibrillary brain tangles in an aged nonhuman primate.
New Study Shows that Fetal Cells Transplanted into the Brain to Treat Parkinson's Disease May Not Function Long Term
Neurons grafted into the brain of a patient with Parkinson's disease fourteen years ago have developed Lewy body pathology, the defining pathology for the disease, according to research by Jeffrey H. Kordower, PhD, and associates and published in the April 6 issue of Nature Medicine.
Study finds mix of disease processes at work in brains of most people with dementia
Few older people die with brains untouched by a pathological process, however, an individual's likelihood of having clinical signs of dementia increases with the number of different disease processes present in the brain.
Loneliness associated with increased risk of Alzheimer's disease
Lonely individuals may be twice as likely to develop the type of dementia linked to Alzheimer's disease in late life as those who are not lonely, according to an article in the February issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
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The Nature of Disease: Pathology for the Health Professions by Thomas H McConnell (Author) Geared to allied health students and written in an engaging narrative style, this pathology text is an easy-to-read primer on the etiology and pathogenesis of human disease. This unique book provides a basic understanding of pathology without microscopic pathology and molecular biology details that health professions students do not need. Each chapter reviews normal anatomy and physiology, explains the development of common diseases, lists the major determinants of disease, presents clinical case studies, and includes end-of-chapter problem-solving questions. A bound-in CD-ROM includes animations and a 250-question quiz. Faculty resources include a 2,000-question test bank and PowerPoint slides with lecture notes. |
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The Nature Of Disease: Pathology For The Health Professions Plus Liveadvise Online Student Tutoring And Teaching Advise by Lippincott Williams & Wilkins The Nature of Disease: Pathology for the Health Professions Plus LiveAdvise Online Student Tutoring and Teaching Advise : The Nature of Disease: Pathology for the Health Professions Plus LiveAdvise Online Student Tutoring and Teaching Advise Pub Date: April 2007 Product Type: Print Author/s: Thomas H McConnell MD, FCAP Geared to allied health students and written in an engaging narrative style, this pathology text is an easy-to-read primer on the etiology and pathogenesis of human disease. This unique book provides a basic understanding of pathology without microscopic pathology and molecular biology details that health professions students do not need. Each chapter reviews normal anatomy and physiology, explains the development of common diseases, lists the major... |
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