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A new light on the mechanisms of early stage liver reperfusion injury
May 08, 2009Reperfusion of a previously ischemic tissue is associated with additional injury leading to structural and functional alterations in many organs including the liver. The injury induced during reperfusion is evolved a biphasic pattern consisting of an early stage started upon reoxygenation and a delayed phase. It is thought that reactive oxygen species formation during reperfusion induces a cascade of series of cellular events that eventually leads to hepatocellur injury. However, the detailed mechanisms of cell death and the structural alterations induced during different stages of reperfusion injury i.e. the early stage, are not completely determined yet.
A research article to be published on April 28, 2009 in the World Journal of Gastroenterology addressed this question. The research team led by Dr. HA Arab at University of Tehran carried out a study to characterize the feature of the injury induced in the early stage of reperfusion in the rat liver.
The authors examined the effects of 60 min lobar ischemia followed by different periods of 5, 10, 30, 45, 60 and 120 min reperfusion. It was found that cell vacoulations, bleb formation and focal hepatitis were the most important changes induced by in vivo lobar ischemia in the rat liver. However, during reperfusion not only some changes including bleb formation was reduced, but some other alterations including portal hepatitis, inflammation and the induction of apoptosis, were occurred. Biochemical analysis showed that the amounts of lactate dehydrogenase, alanine aminotransfrase and aspartate aminotransfrase, creatinine and urea were significantly increased in the serums obtained from the animals exposed to hepatic ischemia-reperfusion. The results of this study indicate that the occurrence of inflammation and the subsequent cell death by apoptosis are the most important changes in the early stage of hepatic reperfusion injury and the presence of apoptotic bodies were augmented as the time of reperfusion was increased.
World Journal of Gastroenterology
World Journal of Gastroenterology
Reperfusion Current Events and Reperfusion News RSSInhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Piece from childhood virus may save soldiers' lives
A harmless shard from the shell of a common childhood virus may halt a biological process that kills a significant percentage of battlefield casualties, heart attack victims and oxygen-deprived newborns.
Pre-hospital organization: The first links in the chain of survival for heart attack patients
Mortality rate following a heart attack has fallen by more than 50% in Europe over the past 25 years. However, because only minor advances in the medical treatment of AMI are expected over the next decade, it is through organisational changes in the pre-hospital phase that mortality rate will continue this decline to below 5%.
The benefits of reperfusion therapy
The wider use of reperfusion therapy in patients with heart attack (AMI) can save millions of lives in Europe.
Stent for life initiative
Primary angioplasty (with stent implantation) is the most effective therapy for acute myocardial infarction (AMI), but it is not available to many patients, even though most European countries have sufficient resources (ie, catheterisation laboratories) for its wider use.
New strategies for reperfusion therapy
A new trial has begun in order to ascertain once and for all whether the best strategy for patients who cannot receive P-PCI is early fibrinolysis, together with mandated angiography.
Irregular heart rhythm before or after cardiac catheterization linked to risk of death
Certain heart attack patients who experience a rapid, abnormal heart rhythm before or after a coronary artery intervention or stent placement have a significantly higher risk of death within 90 days of the procedure.
Explaining trends in heart attack: prevention has improved, mortality rates are down, hospitalisation remains the same
A report in Circulation from the Framingham Heart Study, which compared acute myocardial infarction (AMI) incidence in 9824 men and women over four decades, has proposed an explanation for the apparent paradox of improved prevention, falling mortality rates but stable rates of hospitalisation.
Efficacy of stents is improved when their placement is determined by arterial blood flow measurement
Reperfusion therapy in the form of percutaneous coronary intervention (PCI) is now the recommended first treatment for victims of acute myocardial infarction.
An ESC statement on gender differences in medical care and survival after myocardial infarction
A paper published online by the journal Circulation on 8 December 2008 concluded that, while men and women have a similar in-hospital death rate following acute myocardial infarction, women with STEMI had an adjusted mortality rate almost twice as high as men (10.2% versus 5.5%).
More Reperfusion Current Events and Reperfusion News Articles
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Cellular, Biochemical, and Molecular Aspects of Reperfusion Injury (Annals of the New York Academy of Sciences) by Dipak K. Das (Editor) This volume provides presentations on many aspects of "reperfusion injury". Every vital organ undergoing ischaemic insult, transplantation or vascular surgery, is subject to reperfusion and thus to the likelihood of injury. This text describes the mechanisms of such injury, from pathophysiology to molecular aspects, in the brain, heart, lung, liver, kidney, intestines and joints. It also discusses the possible direction of future research in this relatively new area. The papers which constitute this work were originally presented at a conference held by the New York Academy of Sciences on July 11-14, 1993, in New York. | |
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The Ecg In Acute Mi An Evidence-based Manual Of Reperfusion Therapy by Lippincott Williams & Wilkins The ECG in Acute MI An Evidence-Based Manual of Reperfusion Therapy : The ECG in Acute MI An Evidence-Based Manual of Reperfusion Therapy Pub Date: April 2002 Product Type: Print Author/s: Stephen W Smith MD, FACEP; Deborah L Zvosec PhD; Timothy D Henry MD, FACC, FACCP, FACP; Scott W Sharkey MD, FACC, FACCP, FACP Quick and accurate interpretation of an ECG is vital in determining the use of reperfusion therapy. Learn to provide appropriate and timely therapy through morphology pattern recognition of ischemia, infarction and pseudoinfarction. This text is punctuated by subtle ECGs illustrating the anatomy and reciprocity of leads, enabling analysis and interpretation through spatial perspectives and logical efforts rather than rote memorization. Clinical context is... |
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The ECG in Acute MI: An Evidence-Based Manual of Reperfusion Therapy by Stephen Smith (Author), Deborah L Zvosec (Author), Timothy D Henry (Author), Scott W Sharkey (Author) Univ. of Minnesota, Minneapolis. Reference provides essential clinical guidance to interpret the difficult ECG and determine the need for reperfusion therapy. Includes key points, more than 200 12-lead ECGs, more than 200 case histories, and an annotated bibliography. Softcover. DNLM: Myocardial Infarction--diagnosis. |
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Intermittent Ischemia-Reperfusion As Operative Technique for Cabg-Surgery: An Experimental Study (Acta Biomedica Lovaniensia, 193) by Christiaan Van Kerrebroeck (Author) | |
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Ischemia: Reperfusion Injury of Skeletal Muscle (Medical Intelligence Unit) by Gary A. Fantini (Editor) This publication represents an up-to-date summary of the current understanding of reoxygenation injury in skeletal muscle and outlines future directions of those who will lead the way in this field. Skeletal muscle is generally more tolerant of ischemia reperfusion injury than other organ systems such as brain, heart, kidney, liver and bowel. Current knowledge regarding the pathophysiology of such injury has attracted correspondingly less attention and has been relatively slow to accumulate. This monograph brings together acknowledged leaders who have focused their research efforts on identifying mechanisms of reoxygenation injury in skeletal muscle; the virtual plethora of pathways and cytokines involved in the mediation of cellular injury is attested to by the number and diversity of... | |
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Ischemia and Reperfusion of Various Organs: Injury Mechanisms, Methods of Prevention and Treatment by M. V. Bilenko (Author) Throughout the world, cardiovascular diseases associated with ischemic and reperfusion organ injuries are among the main factors of human mortality. Hence, the analysis of mechanisms responsible for these injuries and the development of approaches to their prevention and treatment present a pressing problem for specialists in biology and medicine. This book is based on firsthand experience gained by the author and her research team during many years of experimental studies, supported by the analysis of abundant literature published between 1970 and 1999. It deals with the comparative assessment of ischemic and reperfusion injuries and their mechanisms in vitally important organs differing in their sensitivity to oxygen deficiency, metabolic activity, and provision with... |
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Myocardial Ischemia: Mechanisms, Reperfusion, Protection (Experientia Supplementum) by Morris Karmazyn (Editor) University of Western Ontario, Canada. |
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Protection Against Ischemia/Reperfusion Damage of the Heart by Yasushi Abiko (Editor), M. Karmazyn (Editor) How to protect against ischemia/reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage-producing mechanism is not yet fully understood. This book provides the latest information on the pathophysiology of ischemia/reperfusion damage and presents new ideas for more effective methods for protection. In the first two sections, the roles of such factors as various ions and phospholipids that modulate ischemia/reperfusion damage are explored, providing a clear and updated explanation of the mechanisms involved. In the third section, the myocardial and vascular remodeling procedure in hearts that have undergone ischemia/reperfusion is explained in terms of signal... | |
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Rolle von T-Zellen bei Ischämie-Reperfusion der Leber (German and German Edition) by Marc Hanschen (Author) Die protektive Wirkung von Immunsuppressiva auf den hepatischen Ischämie-Reperfusionsschaden (I/R-Schaden) deutet darauf hin, dass T-Zellen bei diesem alloantigen-unabhängigen Ereignis eine Rolle spielen. Die Mechanismen der Aktivierung von CD4+ T-Zellen bei alloantigen-unabhängiger I/R der Leber sind jedoch weitgehend ungeklärt. In der aktuellen Arbeit wurde daher die Rolle von CD4+ T-Zellen während hepatischer I/R in vivo analysiert. Erstmals konnte über die Art, die Kinetik und die Lokalisation von CD4+ T-Zell-Endothelzell-Interaktionen Auskunft gegeben werden. CD4+ T-Zellen interagieren mit Thrombozyten während der hepatischen I/R und die Ausbildung des hepatischen I/R-Schadens wird über kostimulatorische Signalwege, wie CD40-CD40L und CD28-B7, moduliert. Dieses findet... |
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Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart. (Letter to the Editor).: An ... Journal of Phytotherapy & Phytopharmacology by Salil K. Bhattacharya (Author), A. Bhattacharya (Author), K. Sairam (Author), S. Ghosal (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Urban & Fischer Verlag on March 1, 2002. The length of the article is 2316 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart. (Letter to the Editor). Author: Salil K. Bhattacharya Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Refereed) Date: March 1, 2002 Publisher: Urban &... |
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