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Sodium bicarbonate reduces incidence of contrast-induced nephropathy
May 13, 2009A meta-analysis of 17 randomised controlled trials has shown that pre-procedural treatment with sodium bicarbonate based hydration is the optimal treatment strategy to prevent contrast-induced nephropathy (CIN). The research, published in the open access journal BMC Medicine, shows that although the benefit may have been overestimated by previous studies, sodium bicarbonate is clearly superior to normal saline.
Hitinder Gurm from the University of Michigan worked with a team of international researchers to study the results of trials featuring a total of 2633 people to assess the effectiveness of saline versus sodium bicarbonate for the prevention of CIN. According to Gurm, "Contrast agents are administered in millions of procedures annually worldwide. In the USA and Europe, contrast-induced nephropathy (CIN) is the third leading cause of acute renal failure in hospitalized patients, accounting for about 10% of hospital-acquired renal failure. Although CIN is generally limited to a transient decline of renal function, it cannot be regarded as a benign complication - as many as 30% of cases result in lasting kidney damage".
The authors found that CIN occurred in 109 of the 1327 patients treated with sodium bicarbonate and in 175 of the 1306 patients who received normal saline. The number needed to prevent one case of CIN was 16. The exact mechanism of CIN is still unknown, but sodium bicarbonate is thought to prevent it by increasing the alkalinity of tubular fluid and thereby limiting free radical production. Gurm said, "Six studies monitored the degree of alkalinization and all but one found a significant increase. Interestingly this one study did not find a benefit of sodium bicarbonate. Therefore, it could be hypothesized that the bicarbonate should be dosed to achieve urinary alkalinization".
BioMed Central
BioMed Central
Calcium and vitamin D may not be the only protection against bone loss
Diets that are high in protein and cereal grains produce an excess of acid in the body which may increase calcium excretion and weaken bones, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).
Scripps research scientists identify blood component that turns bacteria virulent
Scientists from the Scripps Research Institute have discovered the key chemical that signals Bacillus anthracis, the bacterium that causes anthrax, to become lethal. This finding opens up new avenues of exploration for the development of treatments for bacterial infections.
Flies prefer fizzy drinks
While you may not catch a fly sipping Perrier, the insect has specialized taste cells for carbonated water that probably encourage it to binge on food with growing microorganisms.
Sodium hydration therapies equally effective
In patients undergoing cardiac catheterization, contrast dye injection can sometimes cause contrast-induced nephropathy (CIN), otherwise known as acute renal failure.
The Cochrane Library - Update of the latest developments of key health care conclusions and their implications for practice
This alert service highlights some of the key health care conclusions and their implications for practice published this week in The Cochrane Library, 2005 Issue 1.
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Humco Sodium Bicarbonate Powder USP, For Oral Use - 4 Oz by HUMCO HOLDING GROUP. INDICATIONS: Humco Sodium Bicarbonate USP is an antacid for treating excess stomach acid for relief of heartburn, indigestion, etc. Also, absorbs odors. |
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ARM & HAMMER Baking Soda - 12 lb. bag |
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