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p90RSK: A new therapeutic target for liver fibrosis?
May 13, 2009Cirrhosis is a world wide, bad prognosis liver disease and characterized by excessive collagen deposition and liver function damage. In our previous work, p90RSK is observed significantly up-regulated in association with elevated collagen type I levels in rat liver fibrosis. But detail mechanism of this phenomenon is still unknown.
Now, there has a research article to be published on May 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Zhu from Department of Gastroenterology, Jinling Hospital observed the mechanism between p90RSK and collagen type I in vivo and in vitro.
In fibrotic liver tissue, p90RSK was over-expressed and located in activated HSC, which had a significant positive correlation with collagen type I levels. In HSC-T6 cells transfected with RNAi targeted to p90RSK, the expression of collagen type I was down regulated according with that of p90RSK. However, collagen type I promoter activity was not alternated with up-regulation or down-regulation of p90RSK expression. Otherwise, p90RSK RNAi inhibited the proliferation of HSC significantly. These results indicate that P90RSK was a critical element in activation of HSC, which is primarily responsible for excessive collagen expression via the initiation of HSC proliferation during liver fibrosis.
Lacking of the knowledge about pathological proceeding of liver fibrosis results in the lack of effective method to prevent and treat liver fibrosis. These results prefer a new view of p90RSK on liver fibrosis, and thus may provide a new therapeutic target to liver fibrosis.
World Journal of Gastroenterology
Lacking of the knowledge about pathological proceeding of liver fibrosis results in the lack of effective method to prevent and treat liver fibrosis. These results prefer a new view of p90RSK on liver fibrosis, and thus may provide a new therapeutic target to liver fibrosis.
World Journal of Gastroenterology
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Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis.
The use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
UCSD researchers pave the way for effective liver treatments
A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
A potential therapeutic agent for hepatic fibrosis
Accumulating evidence suggests that connective tissue growth factor (CCN2) plays a central role in fibrotic conditions in many organ systems.
Mutations in gene linked to ciliopathies
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies.
Probe position may change results in liver stiffness measurements in transient elastography
A major clinical challenge is to find the best method to evaluate and to manage the increasing numbers of patients with chronic liver disease. Liver biopsy, due to its risks and limitations, is no longer considered mandatory as the first-line indicator of liver injury, and several markers have been developed as non-invasive alternatives.
FibroTest attributes to generate decision trees in hepatitis C
In recent years the use of non-invasive biomarkers to assess liver fibrosis has become widely accepted.
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Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are well-recognized causes of progressive liver disease leading to cirrhosis and hepatocellular carcinoma.
Varicella zoster infection causes severe autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic liver inflammation of unknown etiology that is characterized by the presence of circulatory autoantibodies and ongoing liver tissue damage.
Tobacco Smoke and Alcohol Harm Liver Worse as Combo
Exposure to second-hand smoke and alcohol significantly raises the risk of liver disease, according to researchers at the University of Alabama at Birmingham (UAB).
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Reduction, not abstinence, found effective for heavy drinkers. (Brief Intervention Slows Liver Fibrosis).: An article from: Internal Medicine News by International Medical News Group (Publisher) This digital document is an article from Internal Medicine News, published by International Medical News Group on December 15, 2002. The length of the article is 443 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Reduction, not abstinence, found effective for heavy drinkers. (Brief Intervention Slows Liver Fibrosis). Publication: Internal Medicine News (Magazine/Journal) Date: December 15, 2002 Publisher: International Medical News Group Volume: 35 Issue: 24 Page: 40(1) Distributed by Thomson... | |
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Cooperation of Liver Cells in Health and Disease by Z. Kmiec (Author) Medical Univ. of Gdansk, Poland. Summarizes multiple data suggesting the role of cellular cross-talk for the functions of normal and diseased liver. Includes a concise presentation of the majority of detailed data in 18 tables. Expanded-outline format. Softcover. DNLM: Hepatocytes--physiology. |
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The activin axis in liver biology and disease [An article from: Mutation Research-Reviews in Mutation Research] by C. Rodgarkia-Dara (Author), S. Vejda (Author), N. Erlach (Author), A. Losert (Author) This digital document is a journal article from Mutation Research-Reviews in Mutation Research, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Activins are a closely related subgroup within the TGF@b superfamily of growth and differentiation factors. They consist of two disulfide-linked @b subunits. Four mammalian activin @b subunits termed @b"A, @b"B, @b"C, and @b"E, respectively, have been identified. Activin A, the homodimer of two @b"A subunits, has important regulatory functions in reproductive biology, embryonic development, inflammation, and tissue repair. Several intra- and extracellular antagonists, including the... |
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Molecular and Cell Biology of Liver Fibrogenesis (Falk Symposium) by A.M. Gressner (Editor), G. Ramadori (Editor) This volume, the proceedings of the International Falk Symposium held in Marburg, Germany, in January 1992, summarizes the most recent advances in the study of cellular and molecular mechanisms of fibrosis provided by contributions from the leading scientists in this field. It updates our knowledge on the basic components of fibrosis, on the cellularorigin and degradation of matrix components, on peptide and non-peptide mediators, cellular cooperation and other mechanisms of fibrogenesis, on the role of the extracellular matrix as modulator of fibrogenesis, and on some aspects of antifibrotic trials and biochemical monitoring of the development of fibrosis. Since liver fibrogenesis has, to a certain extent, attained the status of a model for fibrotic tissue reactions that... | |
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Liver Cirrhosis by K. Okita (Editor) Yamaguchi Univ., Yamaguchi, Japan. Proceedings of the 1999 Yamaguchi Symposium on Liver Diseases, useful for physicians and hepatologists interested in hepatic fibrogenesis and hepatocarcinogenesis. Novel approaches for treatment of hepatic disease, including gene therapy. |
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