 |
|
p90RSK: A new therapeutic target for liver fibrosis?
May 13, 2009Cirrhosis is a world wide, bad prognosis liver disease and characterized by excessive collagen deposition and liver function damage. In our previous work, p90RSK is observed significantly up-regulated in association with elevated collagen type I levels in rat liver fibrosis. But detail mechanism of this phenomenon is still unknown.
Now, there has a research article to be published on May 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Zhu from Department of Gastroenterology, Jinling Hospital observed the mechanism between p90RSK and collagen type I in vivo and in vitro.
In fibrotic liver tissue, p90RSK was over-expressed and located in activated HSC, which had a significant positive correlation with collagen type I levels. In HSC-T6 cells transfected with RNAi targeted to p90RSK, the expression of collagen type I was down regulated according with that of p90RSK. However, collagen type I promoter activity was not alternated with up-regulation or down-regulation of p90RSK expression. Otherwise, p90RSK RNAi inhibited the proliferation of HSC significantly. These results indicate that P90RSK was a critical element in activation of HSC, which is primarily responsible for excessive collagen expression via the initiation of HSC proliferation during liver fibrosis.
Lacking of the knowledge about pathological proceeding of liver fibrosis results in the lack of effective method to prevent and treat liver fibrosis. These results prefer a new view of p90RSK on liver fibrosis, and thus may provide a new therapeutic target to liver fibrosis.
World Journal of Gastroenterology
Lacking of the knowledge about pathological proceeding of liver fibrosis results in the lack of effective method to prevent and treat liver fibrosis. These results prefer a new view of p90RSK on liver fibrosis, and thus may provide a new therapeutic target to liver fibrosis.
World Journal of Gastroenterology
Liver Fibrosis Current Events and Liver Fibrosis News RSSUCSD researchers pave the way for effective liver treatments
A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
A potential therapeutic agent for hepatic fibrosis
Accumulating evidence suggests that connective tissue growth factor (CCN2) plays a central role in fibrotic conditions in many organ systems.
Mutations in gene linked to ciliopathies
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, have discovered a connection between mutations in the INPP5E gene and ciliopathies.
Probe position may change results in liver stiffness measurements in transient elastography
A major clinical challenge is to find the best method to evaluate and to manage the increasing numbers of patients with chronic liver disease. Liver biopsy, due to its risks and limitations, is no longer considered mandatory as the first-line indicator of liver injury, and several markers have been developed as non-invasive alternatives.
FibroTest attributes to generate decision trees in hepatitis C
In recent years the use of non-invasive biomarkers to assess liver fibrosis has become widely accepted.
Is telmisartan effective in treating non-alcoholic steatohepatitis?
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are well-recognized causes of progressive liver disease leading to cirrhosis and hepatocellular carcinoma.
Varicella zoster infection causes severe autoimmune hepatitis
Autoimmune hepatitis (AIH) is a chronic liver inflammation of unknown etiology that is characterized by the presence of circulatory autoantibodies and ongoing liver tissue damage.
Tobacco Smoke and Alcohol Harm Liver Worse as Combo
Exposure to second-hand smoke and alcohol significantly raises the risk of liver disease, according to researchers at the University of Alabama at Birmingham (UAB).
Hepatitis C Treatment Reduces the Virus but Liver Damage Continues
Treating patients who have chronic hepatitis C and advanced liver disease with long-term pegylated interferon significantly decreased their liver enzymes, viral levels and liver inflammation, but the treatment did not slow or prevent the progression of serious liver disease, a study finds.
Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease
A new study shows that an imaging technology developed by Mayo Clinic researchers can identify liver fibrosis with high accuracy and help eliminate the need for liver biopsies. Liver fibrosis is a common condition that can lead to incurable cirrhosis if not treated in time.
More Liver Fibrosis Current Events and Liver Fibrosis News Articles
|
Fat Storing Cells and Liver Fibrosis (Falk Symposium) by Calgero Surrenti (Editor), A. Casini (Editor), S. Milani (Editor), M. Pinzani (Editor) The field of liver fibrosis has become of great interest in the last decade. Although knowledge of the mechanisms leading to liver fibrogenesis and fibrosis has dramatically improved during the last 3--4 years, we are still at the edge of the truth. Several reports have stressed the role of nonparenchymal cells as the main producers of hepatic extra-cellular matrix. In particular, fat-storing cells (also known as Ito cells or lipocytes or perisinusoidal stellate cells) have been recently shown to play a major role in this process. The Falk Symposium No. 71 was dedicated to basic science and clinical aspects of fat storing cells and liver fibrosis, and brought together an international group of investigators to highlight unsolved problems and to discuss common strategies of... | |
 |
Dan Shen Pian - Salvia Miltiorrhiza Chinese Medicine Formula for Circulation Improvement - 60 Tablets - Buy 9 Get 10 Shipped! by GHTC Traditional Chinese medicine to help better blood circulation, to prevent stroke. It also can help chronic liver by carrying more blood flow into the area. It may protect kidney tissues from damage caused by diabetes. |
|
Noninvasive device measures liver fibrosis.(Clinical Rounds): An article from: Family Practice News by Jeff Evans (Author) This digital document is an article from Family Practice News, published by International Medical News Group on March 15, 2005. The length of the article is 911 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Noninvasive device measures liver fibrosis.(Clinical Rounds) Author: Jeff Evans Publication: Family Practice News (Magazine/Journal) Date: March 15, 2005 Publisher: International Medical News Group Volume: 35 Issue: 6 Page: 68(2) Distributed by Thomson... | |
|
Inhibition of C[Cl.sub.4]-induced liver fibrosis by Piper longum Linn.?(SHORT COMMUNICATION): An article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology by A.J.M. Christina (Author), G.R. Saraswathy (Author), S.J. Heison Robert (Author), R. Kothai (Author), N. Chidambaranathan (Author), G. Nalini (Author), R.L. Therasal (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on February 1, 2006. The length of the article is 2153 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Inhibition of C[Cl.sub.4]-induced liver fibrosis by Piper longum Linn.?(SHORT COMMUNICATION) Author: A.J.M. Christina Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) Date: February 1, 2006 Publisher: Thomson Gale Volume: 13 Issue: 3 Page: 196(3) Distributed... | |
|
SUR9 Heart-lung-liver transplant for cystic fibrosis. (Surgery).(Brief Article): An article from: Southern Medical Journal by Paul E. Wise (Author), J. Kelly Wright (Author), William C. Chapman (Author), Davis C., Jr. Drinkwater (Author), Robin N. Pierson (Author), C. Wright Pinson (Author) This digital document is an article from Southern Medical Journal, published by Southern Medical Association on December 1, 2001. The length of the article is 350 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: SUR9 Heart-lung-liver transplant for cystic fibrosis. (Surgery).(Brief Article) Author: Paul E. Wise Publication: Southern Medical Journal (Refereed) Date: December 1, 2001 Publisher: Southern Medical Association Volume: 94 Issue: 12 Page: S32(1) Article Type: Brief Article Distributed by Thomson... | |
 |
Dan Shen Pian - Chinese Medicine Formula for Circulation Improvement - 2x60 Tablets by GHTC Traditional Chinese medicine to help better blood circulation, to prevent stroke. It also can help chronic liver by carrying more blood flow into the area. It may protect kidney tissues from damage caused by diabetes. |
|
Reduction, not abstinence, found effective for heavy drinkers. (Brief Intervention Slows Liver Fibrosis).: An article from: Internal Medicine News by International Medical News Group (Publisher) This digital document is an article from Internal Medicine News, published by International Medical News Group on December 15, 2002. The length of the article is 443 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Reduction, not abstinence, found effective for heavy drinkers. (Brief Intervention Slows Liver Fibrosis). Publication: Internal Medicine News (Magazine/Journal) Date: December 15, 2002 Publisher: International Medical News Group Volume: 35 Issue: 24 Page: 40(1) Distributed by Thomson... | |
 |
Cooperation of Liver Cells in Health and Disease by Z. Kmiec (Author) Medical Univ. of Gdansk, Poland. Summarizes multiple data suggesting the role of cellular cross-talk for the functions of normal and diseased liver. Includes a concise presentation of the majority of detailed data in 18 tables. Expanded-outline format. Softcover. DNLM: Hepatocytes--physiology. |
 |
Vitamin E 100 VCaps Nature's Way by Nature's Way Natural Vitamin E as d-alpha tocopherol is a powerful antioxidant that combats damaging free radicals.Natural vitamin E Beneficial Effectss oxidation of LDL cholesterol. |
|
Blood test could replace liver biopsy for MTX users: hepatic fibrosis unlikely with normal result. (PIIINP).(methotrexate): An article from: Skin & Allergy News by Kathryn Demott (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on August 1, 2002. The length of the article is 572 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Blood test could replace liver biopsy for MTX users: hepatic fibrosis unlikely with normal result. (PIIINP).(methotrexate) Author: Kathryn Demott Publication: Skin & Allergy News (Magazine/Journal) Date: August 1, 2002 Publisher: International Medical News Group Volume: 33 Issue: 8 Page: 1(2) Distributed by Thomson... |
| © 2009 BrightSurf.com |