 |
|
Monash researchers lead the way in blood clotting discovery
May 26, 2009A Monash-led research team has discovered an entirely new mechanism that promotes blood clot formation - a major breakthrough that will impact on treatment and prevention of heart disease and stroke.
The discovery is today published in the prestigious Nature Medicine journal.
The discovery is the result of a decade-long research project led by Professor Shaun Jackson, Dr Warwick Nesbitt and Erik Westein from the Australian Centre for Blood Diseases (ACBD) at Monash University.
The study has discovered a new link between disturbed blood flow and blood clotting. ACBD research director Professor Shaun Jackson said that the association between disturbed blood flow and blood clotting was identified more than 150 years ago however it has proven extremely difficult to work out the mechanism by which blood flow activates the clotting mechanism.
"Changes in our arteries are a normal feature of the ageing process leading to disturbances in blood flow. Our work identifies the precise mechanism by which these blood flow changes activate the clotting process, increasing the risk of heart attack and stroke," Professor Jackson said.
Working in collaboration with scientists in the Department of Mechanical Engineering and the Division of Biological Engineering, Monash University and the School of Electronics and Computer Engineering at RMIT University in Melbourne, the ACBD researchers developed sophisticated new techniques that have helped define the link between disturbed blood flow and clot formation.
Lead author Dr Nesbitt explains that this new clotting mechanism is not sensitive to anti-clotting drugs, such as aspirin, clopidogrel or warfarin, defining an important new mechanism responsible for anti-clotting drug resistance.
"This discovery may partly explain the lack of effectiveness of commonly used anti-clotting therapies and may also lead to the development of new and innovative approaches to prevent heart disease and stroke." Dr Nesbitt said.
Blood clotting diseases are Australia's major healthcare problem affecting more than 50 per cent the adult population and kills one Australian nearly every ten minutes. The development of a clot in the circulation to the heart or brain (causing a heart attack or stroke, respectively) is an enormous clinical problem, responsible for more deaths in the community than any other disease.
Despite intense investigation over the last 40 years into the discovery and development of more effective anti-clotting drugs, the impact of these therapies on mortality rates has remained disappointingly low, with less than one in six patients taking anti-clotting therapies avoiding a fatal clotting event.
Mr Westein, co-lead author of the study, said the situation was likely to worsen in the future due to the rapidly growing incidence of obesity and diabetes. "People with diabetes are typically more resistant to the benefits of anti-clotting therapy, thus there is a pressing need for the identification and development of more effective approaches in the prevention of blood clotting," Mr Westein said.
Monash University
The study has discovered a new link between disturbed blood flow and blood clotting. ACBD research director Professor Shaun Jackson said that the association between disturbed blood flow and blood clotting was identified more than 150 years ago however it has proven extremely difficult to work out the mechanism by which blood flow activates the clotting mechanism.
"Changes in our arteries are a normal feature of the ageing process leading to disturbances in blood flow. Our work identifies the precise mechanism by which these blood flow changes activate the clotting process, increasing the risk of heart attack and stroke," Professor Jackson said.
Working in collaboration with scientists in the Department of Mechanical Engineering and the Division of Biological Engineering, Monash University and the School of Electronics and Computer Engineering at RMIT University in Melbourne, the ACBD researchers developed sophisticated new techniques that have helped define the link between disturbed blood flow and clot formation.
Lead author Dr Nesbitt explains that this new clotting mechanism is not sensitive to anti-clotting drugs, such as aspirin, clopidogrel or warfarin, defining an important new mechanism responsible for anti-clotting drug resistance.
"This discovery may partly explain the lack of effectiveness of commonly used anti-clotting therapies and may also lead to the development of new and innovative approaches to prevent heart disease and stroke." Dr Nesbitt said.
Blood clotting diseases are Australia's major healthcare problem affecting more than 50 per cent the adult population and kills one Australian nearly every ten minutes. The development of a clot in the circulation to the heart or brain (causing a heart attack or stroke, respectively) is an enormous clinical problem, responsible for more deaths in the community than any other disease.
Despite intense investigation over the last 40 years into the discovery and development of more effective anti-clotting drugs, the impact of these therapies on mortality rates has remained disappointingly low, with less than one in six patients taking anti-clotting therapies avoiding a fatal clotting event.
Mr Westein, co-lead author of the study, said the situation was likely to worsen in the future due to the rapidly growing incidence of obesity and diabetes. "People with diabetes are typically more resistant to the benefits of anti-clotting therapy, thus there is a pressing need for the identification and development of more effective approaches in the prevention of blood clotting," Mr Westein said.
Monash University
Blood Clotting Current Events and Blood Clotting News RSSAlternatively spliced tissue factor identified as promising new biomarker for aggressive cancers
A recently discovered form of the protein that triggers blood clotting may play a key role in the molecular mechanisms leading to the growth of certain metastatic cancers, according to new research reported by an international team of scientists.
'Superobesity,' chronic disease burden associated with risk of death following bariatric surgery
Veterans classified as superobese and those with a higher chronic disease burden appear more likely to die within a year of having bariatric surgery, according to a report in the October issue of Archives of Surgery, one of the JAMA/Archives journals.
Super sticky barnacle glue cures like blood clots
Barnacles are a big problem for boats. Adhering to the undersides of vessels, carpets of the crustaceans can increase fuel consumption by as much as 25%.
Liver cells grown from patients' skin cells
Scientists at The Medical College of Wisconsin in Milwaukee have successfully produced liver cells from patients' skin cells opening the possibility of treating a wide range of diseases that affect liver function.
New blood-thinning drug safer than rat poison
In an article reviewed by F1000 Medicine Faculty Members Robert Ruff, Brian Olshansky and Luis Ruilope, the blood-thinner dabigatran is shown to protect against stroke, blood clotting and major bleeding as effectively as warfarin, but with fewer side effects.
Scientists pinpoint protein link to fat storage
A protein found present in all cells in the body could help scientists better understand how we store fat.
New research confirms potential deadly nature of emerging new monkey malaria species in humans
Researchers in Malaysia have identified key laboratory and clinical features of an emerging new form of malaria infection.
Pregnancy complications are a stress test for future maternal health and pregnancies
Predicting whether pregnancy complications affect long-term maternal health as well as future pregnancies is at the heart of two studies conducted by researchers in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.
New American College of Surgeons risk calculator determines colorectal surgery risk
New research published in the June issue of the Journal of the American College of Surgeons shows that a risk calculator developed by the American College of Surgeons (ACS) can help surgeons provide patients with more detailed and accurate preoperative information about the risk of death and complications following colorectal surgery.
Gene therapy technique thwarts cancer by cutting off tumor blood supply
University of Florida researchers have come up with a new gene therapy method to disrupt cancer growth by using a synthetic protein to induce blood clotting that cuts off a tumor's blood and nutrient supply.
More Blood Clotting Current Events and Blood Clotting News Articles
|
New Blood Clotting Factors by F. Koller (Editor) | |
 |
Celox First Aid Temporary Traumatic Wound Treatment - 15g Pouch by SAMMedical CELOXTM is the newest generation of emergency hemostatic agents. Simpler to use and safer than older technologies, CELOX granules quickly control even severe arterial bleeding. Just pour it in, pack it, and apply pressure. No specific training is required. CELOX is not exothermic and won't burn the victim or caregiver. And CELOX works in hypothermic conditions and clots Heparinized blood. CELOX is safe to use for the entire body including head, neck and chest wounds. Most importantly, CELOX can be used instantly and without hesitation as a fast, safe and simple emergency treatment for serious bleeding. Average Time to Clot Whole Blood: 30.5 Seconds Average Time to Clot Heparinized Blood: 48 Seconds Controls Major Arterial Bleeding CELOXs unusual properties have been confirmed in wound... |
 |
HemoClot Blood Clotting Gel, 1 oz. by Life Science Products HemoClot is an aid to stop bleeding in animals caused by minor cuts and wounds. It can be used for nail and beak trimming, tail docking, and ear cropping. Do not use in deep wounds or on burns |
 |
Botanic Choice Super EPA (Pack of 4) by Botanic Choice Omega 3 EFAs (Essential Fatty Acids) are essential for healthy arteries, blood pressure already in normal range, and triglycerides. The EFAs in cold water fish oil are believed to be the reasons why Greenland Eskimos (whose diet is mainly fish) are known for having such good heart and circulatory health. Two softgels of our high potency Super EPA Omega 3 fish oil give you 2000 mg. of fish oil and 1398 mg. of other beneficial fatty acids, 360 mg. of EPA and 240 mg. of DHA |
 |
Von Willebrand Disease Part of the award winning public television series Healthy Body/Healthy Mind. Most people wouldn't give a second thought to a minor cut. But for individuals with von Willebrand disease, bleeding is often a cause for concern, particularly when it involves a serious injury or surgery. Von Willebrand disease is a hereditary condition, making it the most common bleeding disorder. It afflicts men and women, as well as children. Though incurable and often challenging to diagnose, there are numerous medications that can be used to effectively control and manage this condition. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
 |
Blood STOP Hemostatic Gauze by TITLE Boxing A hemostatic gauze that contains the finest oxidized and regenerated cellulose for a natural solution to bleeding control. Generous 2" x 2" sterilized size fits perfectly in front pocket or corner bag. Cut to size and apply to cuts to help stop bleeding in seconds. When applied correctly Blood Stop helps seal wounds, speed coagulation and dissolves into a clear gel in seconds. |
 |
LONG LIFE TEAS, Organic Earl Grey Tea - 20 bags by LONG LIFE TEAS Legend has it that a Chinese Mandarin gave the recipe for this classic tea to the second British Earl Grey. One of the secrets of this blend is the fragrant oil of Bergamot, a small citrus fruit from the Mediterranean region. Suggested Use: For Herbal and black teas, bring fresh cold spring water to a rolling boil. For green tea, heat just until steam develops but not to a boil. Pour 1 cup water over each tea bag and allow to steep 3 to 5 minutes. The longer it steeps the better it tastes. Relax, enjoy the developing aroma and color, anticipate the pleasure of a perfect cup of tea. Customize your tea - because herbs extract at different rates you can increase sweetness or intensity simply by steeping longer. Decaffeinate your green and black tea naturally! Pour... |
 |
Impaired Mobility: Physical Consequences (Immobility, Preventing Complications) (Volume One) Also With: Concept Media (Primary Contributor) Describes alterations in body functions occurring with impaired mobility. Common problems such as muscular atrophy, fluid and electrolyte disturbances, disorders in blood clotting mechanisms, disuse osteoporosis, retained respiratory secretions, and urinary stasis are discussed along with their long-term negative impact on patient health. |
|
BLOOD CLOTTING FACTORS PROCEEDINGS OF THE 4TH INTERNATIONAL CONGRESS OF BIOCHEMISTRY VIENNA 1-6 SEPTEMBER 1958 VOLUME X by E. EDITED BY DEUTSCH (Author) | |
 |
Organic Hojicha Roasted Green 16 Bags by Traditional Medicinals Tea The most well known Japanese green tea variety is known as "Bancha." Hojicha is made by roasting Bancha leaves at a high temperature until they turn reddish-brown and take on a strong aromatic fragrance and roasted flavor. How does it taste? Pleasantly nutty and smoky with slightly bitter and astringent undertones. Add a slice of lemon or orange if desired. |
| © 2009 BrightSurf.com |