 |
|
Neurological disorder in golden retriever dogs caused by a mutation in mitochondrial DNA
May 29, 2009Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in Golden Retriever dogs with onset during puppyhood. Affected dogs move in an uncoordinated manner and have sensory deficits. Researchers from the Swedish University of Agricultural Sciences, Uppsala University and the Karolinska Institutet have now revealed that SAN is caused by a mutation in mitochondrial DNA. The study is published May 29 in the open-access journal PLoS Genetics.
The researchers were able to trace back all affected offspring on the maternal side, over more than 10 generations, to a female that lived during the 1970s. This implied a maternal inheritance, which was confirmed by the identification of a one base pair deletion in the mitochondrial tRNA-Tyr gene. Further analyses revealed that the mutation leads to mitochondrial dysfunction, which in turn causes a progressive loss of neurons.
The researchers showed that about five percent of the current Swedish Golden Retriever population carries the mutation causing SAN. The identification of the mutation now allows genetic screening tests to identify carriers and prevent the mutation being transmitted to further generations.
"This is a good example of how a close collaboration between clinicians and geneticists led to a rapid detection of a harmful mutation that can now be eliminated from this dog population to reduce suffering and disease," said co-author Karin Hultin Jäderlund. The study also provides a new animal model for similar mitochondrial disorders in humans, said co-author Izabella Baranowska, and could potentially be used for testing therapeutic approaches.
Public Library of Science
"This is a good example of how a close collaboration between clinicians and geneticists led to a rapid detection of a harmful mutation that can now be eliminated from this dog population to reduce suffering and disease," said co-author Karin Hultin Jäderlund. The study also provides a new animal model for similar mitochondrial disorders in humans, said co-author Izabella Baranowska, and could potentially be used for testing therapeutic approaches.
Public Library of Science
Mitochondrial Current Events and Mitochondrial News RSSUnknowlingly consuming endangered tuna
While most of us would never willingly consume a highly endangered species, doing so might be as easy as plucking sushi from a bento box.
Research reveals lipids' unexpected role in triggering death of brain cells
The lipid that accumulates in brain cells of individuals with an inherited enzyme disorder also drives the cell death that is a hallmark of the disease, according to new research led by St. Jude Children's Research Hospital investigators.
Funny, you don't look related
When Charles Darwin visited the Falkland Islands during the voyage of the Beagle in 1835, he saw a wolf-like species, wrote about it in his diaries and correctly commented that it was being hunted in such large numbers that it would soon become extinct.
'Escaped' proteins add to hearing loss in elderly, UF researchers find
Age-related hearing loss is the most common sensory disorder among the elderly. But scientists are still trying to figure out what cellular processes govern or contribute to the loss.
The bizarre lives of bone-eating worms
The females of the recently discovered Osedax marine worms feast on submerged bones via a complex relationship with symbiotic bacteria, and they are turning out to be far more diverse and widespread than scientists expected.
Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers
The white shark may be the ultimate loner of the ocean, cruising thousands of miles in a solitary trek, but a team of researchers has discovered that the sharks have maintained such a consistent pattern of migration that over tens of thousands of years the white sharks in the northeastern Pacific Ocean have separated themselves into a population genetically distinct from sharks elsewhere in the world.
The first men and women from the Canary Islands were Berbers
A team of Spanish and Portuguese researchers has carried out molecular genetic analysis of the Y chromosome (transmitted only by males) of the aboriginal population of the Canary Islands to determine their origin and the extent to which they have survived in the current population.
Promising novel treatment for human cancer -- Chrysanthemum indicum extract
A series of studies have demonstrated that Chrysanthemum indicum possesses antimicrobial, antiinflammatory, immunomodulatory, and neuroprotective effects.
Whale-sized genetic study largest ever for southern hemisphere humpbacks
After 15 years of research in the waters of the South Atlantic and Indian Oceans, scientists from the Wildlife Conservation Society, the American Museum of Natural History, and an international coalition of organizations have unveiled the largest genetic study of humpback whale populations ever conducted in the Southern Hemisphere.
Too much of a good thing? Scientists explain cellular effects of vitamin A overdose and deficiency
If a little vitamin A is good, more must be better, right? Wrong! New research published online in the FASEB Journal shows that vitamin A plays a crucial role in energy production within cells, explaining why too much or too little has a complex negative effect on our bodies.
More Mitochondrial Current Events and Mitochondrial News Articles
 |
Adam's Gene and the Mitochondrial Eve: A Nonincestuous Descent of Man from Adam and Eve by Dr. Kutty (Author) Rating: Excellent Reviewed by: Eric Jones It s become rather fashionable in literature today for authors to put a new spin on the link between science and religion. As both philosophies continue to collide, spin, and evolve into one another readers have been treated to books like Genome Scientist Francis Collins Language of God , which presents religion from a scientific point of view, along with rebuttals like Richard Dawkins The God Delusion , but nobody makes an argument quite like Ahamed V.P. Kutty. In his similar exploration of these worlds, Kutty presents evidence in the face of a religious question often overlooked among Christians, Muslims, and Jewish practitioners. The question is simple: If incest is a sin, and Adam and Eve were the first humans created by God to... |
![Mitochondrial Blues [Explicit]](http://ecx.images-amazon.com/images/I/619L-SKmm6L._SL160_.jpg) |
Mitochondrial Blues [Explicit] Noah23 (Primary Contributor) |
 |
Mitochondrial Energy Optimizer 120 Capsules with Sodzyme. The Life Extension Foundation Has a 27 Year History of Introducing Life Saving Medical Discoveries and Funding Scientific Research. by Life Extension Foundation Mitochondrial Energy Optimizer incorporates the tremendous advances in our knowledge about the importance of maintaining mitochondrial integrity as we age. Scientists now know that mitochondrial decay in aging is a major driving force behind the aging process.11,12 As the mitochondria burn fatty acids to produce cellular energy, it generates a host of free radicals in the process. That is why a mitochondrial antioxidant like lipoic acid is so critical. This comprehensive formula provides a much more potent form of lipoic acid (called R-lipoic acid) than its predecessor, ChronoForte, along with a more effective form of carnitine, called acetyl-l-carnitine-arginate.* Fatty acids that serve as the fuel for the mitochondria are pulled across the mitochondrial membrane by carnitine and other... |
 |
60 Minutes - Roots (October 7, 2007) Airdate: 10/07/07 Marion West, a Missouri rancher, and Vy Higginsen, a New York City gospel director, never knew they were related until a blood test traced their ancestry back generations and found a common caucasian relative. The problem is, similar tests also told Vy she had ancestors in numerous African tribes and various countries. Lesley Stahl reports on this new field of genetic genealogy, which some say promises its customers more than it can deliver. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
 |
Mitochondrial Disease Awareness Ribbon Mouse Pad by MyHeritageWear.com The Mitochondrial Disease Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Mitochondrial Disease Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Mitochondrial Disease Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
|
Mitochondrial Blues by Noah23 The Duke of Guelph brings us another sizzling solo album. Feat. Orko, Ceschi, Troubadour, Baracuda & many more! Contains the underground hit "Orange Dolphin". | |
 |
Canine Cell Solution II by Healthy Pet Solutions Cell Solution II for Dogs is usually recommended in conjunction with cell Solution for Dogs or Cell Gen Solution for Dogs. It is used to provide additional nutritional support for healthy cellular growth and function. In cases where mitochondrial issues occur it is used by itself to promote healthy cell function. |
 |
Source Naturals R-Lipoic Acid, 100 mg, 60 Tablets by Source Naturals Dietary supplement. Source Naturals R-Lipoic Acid is a natural form of the lipoic acid that your body can synthesize and safely metabolize. It may be better absorbed and more effective as an antioxidant than alpha-lipoic acid. R-lipoic acid by itself may be 10 times more effective than other forms of lipoic acid and has been called the mitochondrial antioxidant because it is a key component of mitochondrial dehydrogenase complexes, which may help to slow the natural aging process in animals. Also, animal research has shown that R-lipoic acid can increase or maintain levels of other antioxidants including CoQ10, Vitamin C, Vitamin E and glutathione, which may decline with age, more efficiently than other forms of lipoic acid (These statements have not been evaluated by the Food and Drug... |
 |
Life Extension - Mitochondrial Energy Optimizer, 120 capsules by Life Extension Mitochondrial Energy Optimizer with SODzymeSuggested UsageTake four capsules daily in divided doses early in the day, or all at once upon wakening, or as recommended by a healthcare practitioner. This product can be taken with or without food.CautionIndividuals with anxiety, manic or bipolar disorder should not use Rhodiola rosea. Those allergic to soy, corn or wheat should take Mitochondrial Energy Optimizer without SODzyme.Supplement FactsServing Size 4 capsulesAmount Per Serving% DVThiamin (vitamin B1) (as thiamine HCl)50 mgSodium25 mgAcetyl-l-carnitine hydrochloride750 mgAcetyl-l-carnitine arginate dihydrochloride750 mgCarnosine1,000 mgSODzyme Proprietary Phytoenzyme Blend (Glycine max, Zea mays, wheat sprout concentrate)300 mgBenfotiamine150 mgLuteolin [from perilla leaf extract... |
 |
Mitochondrial Function and Biogenesis (Topics in Current Genetics) by Carla M. Koehler (Editor), Matthias F. Bauer (Editor) Mitochondria are complex organelles, possessing a double-membrane and even their own genome, the mtDNA. They play a pivotal role in cellular metabolism, respiration, and production of ATP essential for the normal function of all human organ systems. It is not surprising, therefore, that genetic defects of mitochondrial functions cause a wide spectrum of human diseases. This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level. The 13 contributions written by leading researchers in the field include topics such as: mitochondrial genome... |
| © 2009 BrightSurf.com |