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Environmental pollution increases the risk of liver disease
May 29, 2009A new study is the first to show that there is a previously unrecognized role for environmental pollution in liver disease in the general U.S. adult population. This work builds upon the groups' previous research demonstrating liver disease in highly-exposed chemical workers. The study is being presented during Digestive Disease Week® 2009 (DDW®), the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
"Our study found that greater than one in three U.S. adults had liver disease, even after excluding those with traditional risk factors such as alcoholism and viral hepatitis," said Matthew Cave, MD, assistant professor, department of medicine, division of gastroenterology and hepatology at the University of Louisville. "Our study shows that some of these cases may be attributable to environmental pollution, even after adjusting for obesity, which is another major risk factor for liver disease."
Using the 2003-2004 National Health and Nutrition Examination Survey (NHANES), researchers from the University of Louisville study examined chronic low-level exposure to 111 common pollutants including lead, mercury, PCBs and pesticides and their association with otherwise unexplained liver disease in adults. The specific pollutants included were detectable in 60 percent or more of the 4,500 study subjects.
Dr. Cave added that this analysis used only the ALT liver enzyme as a marker of liver injury, and cautioned that this associative study does not prove causality. However, he added that previous animal studies do suggest causality for many of these chemicals. Dr. Cave and his co-authors also plan to examine the additive effects of environmental pollutants on liver disease in children and adults with risk factors including obesity, viral hepatitis, and alcoholism in the NHANES population.
Dr. Cave will present these data, Chronic Low-Level Exposure to Toxicants Linked to Liver Disease in U.S. Adults (Abstract #289), on Monday, June 1 at 8:30 a.m. CDT in S105, McCormick Place.
American Gastroenterological Association
Dr. Cave added that this analysis used only the ALT liver enzyme as a marker of liver injury, and cautioned that this associative study does not prove causality. However, he added that previous animal studies do suggest causality for many of these chemicals. Dr. Cave and his co-authors also plan to examine the additive effects of environmental pollutants on liver disease in children and adults with risk factors including obesity, viral hepatitis, and alcoholism in the NHANES population.
Dr. Cave will present these data, Chronic Low-Level Exposure to Toxicants Linked to Liver Disease in U.S. Adults (Abstract #289), on Monday, June 1 at 8:30 a.m. CDT in S105, McCormick Place.
American Gastroenterological Association
Liver Disease Current Events and Liver Disease News RSSLargest-ever database for liver proteins may lead to treatments for hepatitis
Scientists at a group of 11 research centers in China are reporting for the first time assembly of the largest-ever collection of data about the proteins produced by genes in a single human organ.
Alcohol Tolerance Switch Found in Fruit Flies
Researchers at North Carolina State University have found a genetic "switch" in fruit flies that plays an important role in making flies more tolerant to alcohol.
Scientists develop novel method to generate functional hepatocytes for drug testing
Scientists have for the first time produced liver cells from adult skin cells using the induced pluripotent stem cell (iPSC) technology.
UCSD researchers pave the way for effective liver treatments
A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
Governor recognizes stem cell research at Einstein
Albert Einstein College of Medicine of Yeshiva University hosted a roundtable discussion on stem cell research with New York Governor David A. Paterson today.
Liver cells grown from patients' skin cells
Scientists at The Medical College of Wisconsin in Milwaukee have successfully produced liver cells from patients' skin cells opening the possibility of treating a wide range of diseases that affect liver function.
Metabolic syndrome linked to liver disease in obese teenaged boys
Researchers studying a large sample of adolescent American boys have found an association between metabolic syndrome, which is a complication of obesity, and elevated liver enzymes that mark potentially serious liver disease.
Penn State College of Medicine research isolates liver cancer stem cells prior to tumor formation
Penn State College of Medicine researchers, in collaboration with colleagues at the University of Southern California, have taken an important step in understanding the role of stem cells in development of liver cancer.
Genetic hint for ridding the body of hepatitis C
More than seventy percent of people who contract Hepatitis C will live with the virus that causes it for the rest of their lives and some will develop serious liver disease including cancer.
HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia?
Previous studies revealed that HBV genotypes as well as mutations in the core promoter, precore or HBx gene have been shown to have an association with the clinical outcome of liver disease, however, this is still controversial.
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