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Tribble 3 can induce non-alcoholic fatty liver disease?
June 11, 2009Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of diabetes. TRB3 could block the insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance.
A research article to be published on May 21, 2009 in the World Journal of Gastroenterology addresses this question. This research, lead by Dr. Yu-Gang Wang and his colleagues in the Department of Gastroenterology, Shanghai Changning Central Hospital, China, used real-time fluorescent quantitative reverse transcription-polymerase chain reaction technology and Western blotting analysis to study the protein expression of TRB3mRNA, Akt and phosphorylation protein kinase B during the progression of NAFLD.
The expression level of TRB3mRNA in NAFLD rats was significantly higher than in normal controls. Also, the expression levels of Akt and p-Akt-Thr308 in NAFLD rats was significantly lower than the control group. Since TRB3 can block insulin signaling pathway through inhibiting Akt activation, which contributes to insulin resistance, it may be an important factor in the occurrence and development of NAFLD. This study provides an experimental basis for future studies on the role of TRB3 in NAFLD. The control of the expression level of TRB3 in liver may become a new target for NAFLD therapy.
World Journal of Gastroenterology
World Journal of Gastroenterology
Gastroenterology Current Events and Gastroenterology News RSSColon cancer screening more effective earlier in day, UCLA study finds
The effectiveness of a screening colonoscopy may depend on the time of day it is performed. According to a new UCLA study, early-morning colonoscopies yielded more polyps per patient than later screenings, and fewer polyps were found hour by hour as the day progressed.
Gastroenterology/hepatology societies release report evaluating fellowship training curriculum
Due to the increasing complexities of treating digestive diseases, allowing gastroenterological (GI) trainee physicians the opportunity to develop enhanced abilities and experiences in specific disease areas or procedures will be a great benefit to patients, according to a "Report of the Multisociety Task Force on GI Training."
Extending treatment after liver transplant may benefit patients with hepatitis C recurrence
Extending hepatitis C treatment for liver transplant patients beyond current practice results in high rates of clearance of the hepatitis C virus from the blood, as well as a low rate of relapse, according to a Henry Ford Hospital study.
Is short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis?
Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer.
Should children undergo surgery without a long period of fasting after feeding?
Blood glucose levels in a lot of patients fed normal liquid food (NLF) and a high calorie diet (HCD) were high.
A new explanation of 'Asian paradox'
Although Helicobacter pylori (H. pylori) has been classified as a class I (or definite) carcinogen by World Health Organization (WHO), the controversy as to why only a minority of infected patients develop gastric cancer still remains.
High-definition Colonoscopy Detects More Polyps, Mayo Clinic Researchers Say
High-definition (HD) colonoscopy is much more sensitive than standard colonoscopy in finding polyps that could morph into cancer, say researchers at the Mayo Clinic campus in Florida.
Mayo Clinic study shows people with heart devices can 'digest' advanced diagnostic technology safely
A new Mayo Clinic study suggests that video capsule endoscopy (CE), a procedure that uses wireless technology in diagnosing intestinal disease, is safe for patients with heart devices.
Deadly stomach infection rising in community settings, Mayo Clinic study finds
Mayo Clinic researchers have found that a sometimes deadly stomach bug, Clostridium difficile is on the rise in outpatient settings.
Barrett's esophagus patients have same survival rates as general population
New Mayo Clinic research has found that survival rates of patients with Barrett's esophagus, which can be a precursor for esophageal cancer, are no different than the survival rates for the general population.
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Current Diagnosis and Treatment in Gastroenterology, Hepatology, and Endoscopy by Norton Greenberger (Author), Richard Blumberg (Author), Robert Burakoff (Author) Complete coverage of diagnosing and treating digestive tract and liver disorders Edited by the world-renown team at Brigham and Women's Hospital of Harvard University, this new addition to the popular CURRENT series provides you with all you need to know for diagnosing and treating digestive tract and liver disorders. CURRENT Diagnosis and Treatment in Gastroenterology, Hepatology, and Endoscopy takes an explicitly clinical approach presented in a highly formatted design. Among its most notable features is thorough coverage of endoscopy and liver disorders. |
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Principles of Clinical Gastroenterology by Tadataka Yamada (Editor), David H. Alpers (Editor), Anthony N. Kalloo (Editor), Neil Kaplowitz (Editor), Chung Owyang (Editor), Don W. Powell (Editor) A Concise, Symptom-Based Textbook for Diagnosis and Decision Making in Clinical Practice Over the past twenty years, thousands of physicians have come to depend on Yamada’s Textbook of Gastroenterology. Its encyclopaedic discussion of the basic science underlying gastrointestinal and liver diseases as well as the many diagnostic and therapeutic modalities available to the patients who suffer from them was—and still is—beyond compare. This new textbook, Principles of Clinical Gastroenterology, is designed to inform practitioners on the features of the major clinical disorders in gastroenterology and hepatology from the point of view of the clinician observing signs and symptoms of a patient under care and management. It is a practical guide to diagnosis and decision... |
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Mayo Clinic Gastroenterology and Hepatology Board Review, Third Edition by Stephen C. Hauser (Editor), Darrell S. Pardi (Editor), John J. Poterucha (Editor) Written by an experienced and dedicated team of Mayo Clinic gastroenterologists and hepatologists, this newly expanded and updated Third Edition of the best-selling Mayo Clinic Gastroenterology and Hepatology Board Review is the go-to comprehensive resource for a complete scope of essential knowledge in all areas of gastroenterology and hepatology and in the related areas of pathology, endoscopy, nutrition, and radiology. The new edition is an easy-to-use, case-based text expertly designed for those preparing to take the gastroenterology board examination and for gastroenterologists in need of recertification. Medical students and residents in the areas of internal medicine and gastroenterology, gastroenterology fellows, and physicians seeking a practical and... |
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The Washington Manual® Gastroenterology Subspecialty Consult (Washington Manual Subspecialty Consult) by Washington University School of Medicine Department of Medicine (Editor), C. Prakash Gyawali (Editor), Thomas M De Fer (Editor), Katherine E Henderson (Editor) Prepared by residents and chief residents with senior faculty advisors at the Washington University School of Medicine, this handbook is an updated, easily accessible quick reference for handling everyday problems encountered in gastroenterology. It covers both inpatient and outpatient approaches with the same front-lines practicality as the world-famous Washington Manual(R) of Medical Therapeutics. The first section covers common symptoms, signs, and laboratory abnormalities; the second section focuses on specific diseases. Chapters are structured to help the clinician develop a logical, systematic approach to these common problems. Key points about the diagnosis and management of disorders are bulleted for easy reference. This edition also includes illustrations. The Washington... |
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Textbook of Gastroenterology, 2 Volume Set (Textbook of Gastroenterology (Yamada)) by Tadataka Yamada (Editor), David H. Alpers (Editor), Anthony N. Kalloo (Editor), Neil Kaplowitz (Editor), Chung Owyang (Editor), Don W. Powell (Editor) Over the past twenty years, thousands of physicians have come to depend on Yamada’s Textbook of Gastroenterology. Its encyclopaedic discussion of the basic science underlying gastrointestinal and liver diseases as well as the many diagnostic and therapeutic modalities available to the patients who suffer from them was—and still is—beyond compare. This new edition provides the latest information on current and projected uses of major technologies in the field and a new section on diseases of the liver. Plus, it comes with a fully searchable CD ROM of the entire content. |
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Little Black Book of Gastroenterology by David W. Hay (Author) Thoroughly revised and updated, the second edition of this pocket-sized handbook provides comprehensive, concise, evidence-based information on the diagnosis and treatment of GI disease. The Little Black Book of Gastroenterology is a convenient resource offering quick access to vital information and makes a great reference for solving pressing problems on the ward or in the clinic. |
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Gastroenterology Resident Pocket Survival Guide (RESIDENT POCKET SURVIVAL GUIDE SERIES) by International Medical Publishing (Publisher) Resident pocket survival guides |
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Sleisenger and Fordtran's Gastrointestinal and Liver Disease e-dition: Pathophysiology, Diagnosis, Management (Gastrointestinal & Liver Disease (Sleisinger/Fordtran)) by Mark Feldman MD (Editor), Lawrence S. Friedman MD (Editor), Lawrence J. Brandt MD (Editor) Access today's best guidance on the diagnosis and treatment of digestive disorders with the new edition of this best-selling reference! International experts provide evidence-based perspectives on all clinically relevant topics, explaining step by step how to apply the latest advances in practice. Succinct yet comprehensive discussions provide just the right amount of clinical detail. The multimedia e-dition includes the traditional printed two-volume set • and access to the complete contents online—fully searchable, and updated weekly by the editors! Includes the traditional printed two-volume set and access to a dynamic web site! * Complete contents of the two-volume set, fully searchable * Weekly content updates – personally overseen by the editors * All of the two-volume set's... |
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Primo Gastro: The Pocket GI/Liver Companion (Guardino, Primo Gastro: The Pocket GI/Liver Companion) by Jason M Guardino (Author) Designed for quick, easy point-of-care reference during hospital rounds and in the outpatient clinic, this pocket book provides clinically relevant information on over 100 gastrointestinal, pancreatic, and hepatic problems and important endoscopy topics. Each topic is presented in easy-to-scan bullet lists and tables on interfacing pages, with headings that include definition, epidemiology, etiology, pathophysiology, clinical manifestations, physical examination, laboratory studies, diagnostic studies, treatments, complications, and prognosis. The latest national treatment guidelines are presented at the top of the page. When appropriate, topics are cross-referenced to each other. |
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Current Diagnosis and Treatment in Gastroenterology (Lange Medical Books) by Scott L. Friedman (Author), Kenneth R. McQuaid (Author), James H. Grendell (Author) This easy-to-use, multipurpose resource is the ideal first stop for answers - for those in practice, on the wards, teaching, or preparing for boards. "Current Diagnosis and Treatment in Gastroenterology" offers brief but expert and up-to-date coverage of gastrointestinal, biliary, hepatic, and pancreatic diseases. With its consistent formatting chapter by chapter, this text makes it simple to locate the practical information you need on diagnosis, testing, disease processes, and up-to-date treatment and management strategies. It is concise, accessible clinical information on gastroenterology. It brings together the best in current recommendations from experts directly involved in patient care and clinical teaching. It provides single-source look-ups of essential topics in diseases of the... |
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