 |
|
What is the relationship between hepatocellular carcinoma and type 2 diabetes mellitus?
June 12, 2009Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related deaths. Type 2 diabetes mellitus has been associated with HCC. However, the relationship between type 2 diabetes mellitus and the underlying liver cirrhosis, and the effects of antidiabetic therapy on HCC risk have not yet been fully evaluated.
A research team led by Dr. Valter Donadon from Pordenone Hospital addressed this question. Their study will be published on May 28, 2009 in the World Journal of Gastroenterology.
Four hundred and sixty five HCC patients, 618 cirrhosis patients and 490 control subjects were enrolled in this study. They evaluated the odds ratio (OR) for HCC by univariate and multivariate analysis. Moreover, OR for HCC in diabetic subjects treated with insulin or sulphanylureas and with metformin were calculated.
The prevalence of diabetes mellitus was 31.2% in HCC, 23.3% in cirrhotic patients and 12.7% in the Control group. By univariate and multivariate analysis, the OR for HCC in diabetic patients were respectively 3.12 (95%CI: 2.2-4.4, P < 0.001) and 2.2 (95%CI: 1.2-4.4, P = 0.01). In 84.9% of cases, type 2 diabetes mellitus was present before the diagnosis of HCC. Moreover, we report an OR for HCC of 2.99 (95%CI: 1.34-6.65, P = 0.007) in diabetic patients treated with insulin or sulphanylureas, and an OR of 0.33 (CI 0.1-0.7, P = 0.006) in diabetic patients treated with metformin.
This study demonstrates that type 2 diabetes mellitus is an independent risk factor for HCC and pre-exists in the majority of HCC patients. In male HCC, patients with type 2 diabetes mellitus, their data shows a direct association of HCC risk with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy.
World Journal of Gastroenterology
The prevalence of diabetes mellitus was 31.2% in HCC, 23.3% in cirrhotic patients and 12.7% in the Control group. By univariate and multivariate analysis, the OR for HCC in diabetic patients were respectively 3.12 (95%CI: 2.2-4.4, P < 0.001) and 2.2 (95%CI: 1.2-4.4, P = 0.01). In 84.9% of cases, type 2 diabetes mellitus was present before the diagnosis of HCC. Moreover, we report an OR for HCC of 2.99 (95%CI: 1.34-6.65, P = 0.007) in diabetic patients treated with insulin or sulphanylureas, and an OR of 0.33 (CI 0.1-0.7, P = 0.006) in diabetic patients treated with metformin.
This study demonstrates that type 2 diabetes mellitus is an independent risk factor for HCC and pre-exists in the majority of HCC patients. In male HCC, patients with type 2 diabetes mellitus, their data shows a direct association of HCC risk with insulin and sulphanylureas treatment and an inverse relationship with metformin therapy.
World Journal of Gastroenterology
Diabetes Mellitus Current Events and Diabetes Mellitus News RSSConsumer Electronics Can Help Improve Patient Health
Electronic tools and technology applications for consumers can help improve health care processes, such as adherence to medication and clinical outcomes like smoking cessation, according to a report by researchers at the Johns Hopkins Bloomberg School of Public Health.
UT Southwestern study shows how substance in grapes may squeeze out diabetes
A naturally produced molecule called resveratrol, found in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet.
Healthy neighborhoods may be associated with lower diabetes risk
Individuals living in neighborhoods conducive to physical activity and providing access to healthy foods may have a lower risk of developing type 2 diabetes in a five-year period, according to a report in the October 12 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
Is inhaled insulin delivery still a possibility? Why has it been a commercial failure?
The commercial failure of Exubera® (Pfizer, New York, NY), the first inhaled insulin product to come to market, led other companies such as Eli Lilly-Alkermes to halt studies of similar drug delivery in development intended to compete for a share of the lucrative diabetes market.
Researchers find drug-eluting stents safe, effective for PCI in diabetics
Results of a multicenter study in Asia, demonstrating that drug-eluting stents are effective with a low rate of complications in diabetic patients, will be presented at the 21st annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium, sponsored by the Cardiovascular Research Foundation (CRF).
Team reveals molecular mechanism underlying a form of diabetes
By investigating a rare and severe form of diabetes in children, University of Iowa researchers have discovered a new molecular mechanism that regulates specialized pancreatic cells and insulin secretion.
New developments in reproductive medicine
Three out of ten women who undergo polar body diagnosis go on to have a child.
ADA publishes practice guidelines for nutrition care for patients with spinal cord injury
The American Dietetic Association has published new evidence-based nutrition practice guidelines for registered dietitians on nutrition care for patients with spinal cord injury.
Pancreatic cancer risk decreased by one anti-diabetic therapy, increased by others
The antidiabetic medication metformin is associated with a reduced risk of pancreatic cancer in diabetics, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association (AGA) Institute.
Pregnancy complications are a stress test for future maternal health and pregnancies
Predicting whether pregnancy complications affect long-term maternal health as well as future pregnancies is at the heart of two studies conducted by researchers in the Department of Obstetrics, Gynecology and Reproductive Sciences at Yale School of Medicine.
More Diabetes Mellitus Current Events and Diabetes Mellitus News Articles
 |
Joslin's Diabetes Mellitus by Alan M. Jacobson (Author), C. Ronald Kahn (Editor), Gordon C Weir (Editor), George L. King (Editor), Alan C. Moses (Editor), Robert J. Smith (Editor) The "bible" on diabetes mellitus is now in its Fourteenth Edition--thoroughly revised and updated by more than 80 noted experts from the Joslin Diabetes Center and other leading institutions worldwide. This edition includes a new eleven-chapter section on hormone action and the regulation of metabolism. The section on definition and pathogenesis now includes chapters on genetics, diabetes in Asia and Africa, and diabetes in U.S. minority groups. Other new chapters cover retinopathy, cardiovascular disease, wound healing, and treatment of women with diabetes. All of the Fourteenth Edition's figures have been completely updated. "Doody's Core Titles™ 2009." |
 |
Diabetes Mellitus: A Practical Handbook by Sue K. Milchovich RN BSN CDE (Author), Barbara Dunn-Long RD (Author) Updated to report on important breakthroughs in diabetes research and armed with the latest information about diet and drugs, this guide focuses on the everyday concerns of diabetics, teaching them how to balance diet, medication, and exercise for optimal health. Focus is provided on new drug delivery methods, including modern inhalers. Filled with illustrations, charts, tables, and worksheets, this is a proven, user-friendly resource for living with diabetes. |
 |
Glucose-Balance - Sale! Dr. Kang's formula for use in treating diabetes mellitus and prevents damage of heart;liver;kidney and atherosclerosis from diabetes. Limited time offer. by Trilight,Inc. From the Western scientific perspective, diabetes mellitus is an inherited endocrine disorder characterized by a variable degree of carbohydrate intolerance and specific vascular lesions (i.e., thickening of the capillary basement membrane.) The endocrine aspect of this disease is the lack of sufficient pancreatic insulin to take up nutrients from the blood, in particular, glucose. The short term danger would then be a sort of tissue starvation leading to rapid fat metabolism leading to ketoacidosis and ultimately to metabolic acidosis, shock and death. The long term dangers involve vascular lesions beginning in the lower extremities and fundus of the eye leading to tissue death, loss of sight and limb amputation. In the short term, immediate symptoms include thirst, hunger and frequent... |
|
Diabetes Mellitus; Pathology for Nurses Video Series | |
 |
Feline Diabetes Solution by Healthy Pet Solutions Healthy Pet Solutions Diabetes Solution for Cats works to rebalance your cat's body. A feline body in balance can normalize the function for the pancreas and promote healthy sugar metabolism. Diabetes Solution is manufactured utilizing pharmaceutical standards and offers the highest concentrations in the industry (30-1 instead of 5-1); higher concentrations equate to superior results. |
 |
Diabetes Type 2 GUIDELINES Pocketcard: American Association of Clinical Endocrinologists (2008) by International Guidelines Center The Diabetes Mellitus Type 2 GUIDELINES Pocketcard provides all that is needed to make accurate clinical decisions at the point of care including: Key points; Treatment Algorithm; Glycemic Control Module; Hypertension (HTN) Management Module; Eye Care Module; Neuropathy Module; Foot Care Module; Cardiac-Peripheral Vascular Module; Renal Disease Module; Current Medication Tables with Brand and Generic Names; Detailed drug information - strengths, formulations, side effects, comments. |
 |
Diabetes Mellitus: A Fundamental and Clinical Text by Derek LeRoith (Editor), Jerrold M Olefsky (Editor), Simeon I Taylor (Editor) National Institutes of Health, Bethesda, MD. Comprehensive reference encompasses the major advances in the basic molecular, cellular, and genetic components of diabetes. Also discusses the standard and new therapeutic modalities. Topics include insulin secretion and action, pregnancy, clinical complications, and more. Previous edition: c2000. DNLM: Diabetes Mellitus. |
 |
Anti-Aging Vibes Carnosine Nutrition Supplement, 60 Capsules by Anti-Aging Vibes A perfect candidate for supplementing the Anti-Aging Vibes Core Program, Carnosine (a dipeptide, or amino acid) has powerful anti-aging properties and is effective in helping to remove glycated proteins arising from carbohydrates. A diet high in carbohydrates can lead to high levels of blood sugar (glucose), which binds with the body's tissue proteins forming an essentially irreversible glycation end product. The Carnosine nutritional supplement, which acts as an anti-glycation nutrient, has many roles in the anti-aging process: It extends life in cultured laboratory cells* It supports the immune system's natural ability to kill mutated cells* It protects against damaging chemicals* It prevents and can possibly reverse glycation* It prevents DNA/protein cross-linking* It protects against... |
 |
Medical Management of Type 2 Diabetes by American Diabetes Association (ADA) (Author) Featuring a recommended approach to diagnosing and treating patients with Type II diabetes This clinical book for health care professionals features the most up-to-date approaches and protocols for diagnosing and treating patients with type 2 diabetes. Over 18 million people are living with diabetes and the majority have been diagnosed as type 2—a group particularly at-risk for cardiovascular complications. Health care practitioners will find this comprehensive resource for type 2 indispensable, providing the most up-to-date guidelines for diagnosis, treatment, glucose, and cardiovascular disease risk factor control as well as nutrition and exercise. Professionals will find the array of treatment options for all stages of cardiovascular... |
 |
Type 2 Diabetes Mellitus:: An Evidence-Based Approach to Practical Management (Contemporary Endocrinology) by Mark N. Feinglos (Editor), Mary Angelyn Bethel (Editor) As the global epidemic of diabetes continues to expand, the prevalence of type 2 diabetes is predicted to double in the next 20 years. Type 2 Diabetes Mellitus: An Evidence-Based Approach to Practical Management addresses this problem by expertly synthesizing the currently available evidence regarding specific issues in diabetes care. Written by an interdisciplinary team of scientists and medical professionals and comprising a wealth of information in a single resource, the book integrates the best evidence for the full range of clinical issues surrounding the evaluation and treatment of type 2 diabetes, including comorbid conditions such as hypertension, hyperlipidemia, and vascular disease. To quantify the strength of evidence supporting current practices, each chapter highlights... |
| © 2009 BrightSurf.com |