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Omega-3 fatty acids appear to impact AMD progression
June 18, 2009Omega-3 fatty acids found in fatty fish such as tuna and salmon may protect against progression of age-related macular degeneration (AMD), but the benefits appear to depend on the stage of disease and whether certain supplements are taken, report researchers at the Laboratory for Nutrition and Vision Research (LNVR), Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University.
The researchers calculated intakes of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) from dietary questionnaires administered to 2,924 men and women, aged 55 to 80 years, participating in an eight-year supplement trial, the Age-Related Eye Disease Study (AREDS) of the National Eye Institute (NEI). The AREDS trial results suggest taking supplements of antioxidants plus zinc prevents progression of late-stage AMD. AREDS study participants were randomly allocated to receive either a placebo or supplements containing the antioxidants vitamins C and E and beta carotene, the minerals zinc and copper, or a combination of both.
"In our study, we observed participants with early stages of AMD in the placebo group benefited from higher intake of DHA, but it appears that the high-dose supplements of the antioxidants and/or the minerals somehow interfered with the benefits of DHA against early AMD progression," says senior author Allen Taylor, PhD, director of the LNVR at the USDA HNRCA. Taylor is also a professor at the Friedman School of Nutrition Science and Policy at Tufts and Tufts University School of Medicine (TUSM).
The antioxidant supplements did not seem to interfere with the protective effects of DHA and EPA against progression to advanced stages of AMD. Participants who consumed higher amounts of DHA and EPA appeared to have lower risk of progression to both wet and dry forms of advanced AMD. The results are published on-line ahead of print in the British Journal of Ophthalmology.
"Data from the present study also shows the supplements and omega-3 fatty acids collaborate with low-dietary glycemic index (dGI) diets against progression to advanced AMD," says corresponding author Chung-Jung Chiu, DDS, PhD, a scientist in the LNVR and an assistant professor at TUSM. "Our previous research suggests a low-GI diet may prevent AMD from progressing to the advanced stage. We hypothesize that the rapid rise of blood glucose initiated by high-GI foods results in cellular damage that retinal cells cannot handle, thus damaging eye tissues."
dGI is a scale used to determine how quickly carbohydrates are broken down into blood sugar, also known as blood glucose. Foods such as sweetened drinks, sodas and white bread are high-GI because they trigger a sharp rise and fall of blood sugar. Low-GI foods, such as whole grain versions of pasta and bread, have a milder effect on blood sugar response. Earlier data published by Taylor and Chiu suggests that daily substitution of five slices of whole grain bread for white bread out of a total intake of 250 g of carbohydrate might cut out almost 8% of advanced AMD over five years. This is readily achievable with little diet behavior modification.
Eating two to three servings of fatty fish such as salmon, tuna, mackerel, shellfish, and herring every week would achieve the recommended daily intake of DHA and EPA. However, the majority of AREDS participants and Americans eat a much lower level than recommended. "If changing dietary habits is not easy, supplementation is an option," says Chiu.
The authors stress it is still premature to conclude dietary recommendations for people with AMD and more studies are warranted. "Taken together, these data indicate that consuming a diet with higher levels of omega-3 fatty acids, antioxidants and low-GI foods may delay compromised vision due to AMD," says Taylor. "The present study adds the possibility that the timing of a dietary intervention as well as the combination of nutrients recommended may be important."
AMD is a progressive disease that attacks central vision, resulting in a gradual loss of eyesight and, in some cases, blindness. The NEI reports that AMD is the most common causes of non-remediable vision loss in Americans over 60.
Tufts University, Health Sciences
The antioxidant supplements did not seem to interfere with the protective effects of DHA and EPA against progression to advanced stages of AMD. Participants who consumed higher amounts of DHA and EPA appeared to have lower risk of progression to both wet and dry forms of advanced AMD. The results are published on-line ahead of print in the British Journal of Ophthalmology.
"Data from the present study also shows the supplements and omega-3 fatty acids collaborate with low-dietary glycemic index (dGI) diets against progression to advanced AMD," says corresponding author Chung-Jung Chiu, DDS, PhD, a scientist in the LNVR and an assistant professor at TUSM. "Our previous research suggests a low-GI diet may prevent AMD from progressing to the advanced stage. We hypothesize that the rapid rise of blood glucose initiated by high-GI foods results in cellular damage that retinal cells cannot handle, thus damaging eye tissues."
dGI is a scale used to determine how quickly carbohydrates are broken down into blood sugar, also known as blood glucose. Foods such as sweetened drinks, sodas and white bread are high-GI because they trigger a sharp rise and fall of blood sugar. Low-GI foods, such as whole grain versions of pasta and bread, have a milder effect on blood sugar response. Earlier data published by Taylor and Chiu suggests that daily substitution of five slices of whole grain bread for white bread out of a total intake of 250 g of carbohydrate might cut out almost 8% of advanced AMD over five years. This is readily achievable with little diet behavior modification.
Eating two to three servings of fatty fish such as salmon, tuna, mackerel, shellfish, and herring every week would achieve the recommended daily intake of DHA and EPA. However, the majority of AREDS participants and Americans eat a much lower level than recommended. "If changing dietary habits is not easy, supplementation is an option," says Chiu.
The authors stress it is still premature to conclude dietary recommendations for people with AMD and more studies are warranted. "Taken together, these data indicate that consuming a diet with higher levels of omega-3 fatty acids, antioxidants and low-GI foods may delay compromised vision due to AMD," says Taylor. "The present study adds the possibility that the timing of a dietary intervention as well as the combination of nutrients recommended may be important."
AMD is a progressive disease that attacks central vision, resulting in a gradual loss of eyesight and, in some cases, blindness. The NEI reports that AMD is the most common causes of non-remediable vision loss in Americans over 60.
Tufts University, Health Sciences
Omega-3 Fatty Acids Current Events and Omega-3 Fatty Acids News RSSFish oil not snake oil
A randomised controlled trial of fish oil given intravenously to patients in intensive care has found that it improves gas exchange, reduces inflammatory chemicals and results in a shorter length of hospital stay.
New study links DHA type of omega-3 to better nervous-system function
The omega-3 essential fatty acids commonly found in fatty fish and algae help animals avoid sensory overload, according to research published by the American Psychological Association.
Nanoparticle protects oil in foods from oxidation, spoilage
Using a nanoparticle from corn, a Purdue University scientist has found a way to lengthen the shelf life of many food products and sustain their health benefits.
Fish food fight: Fish don't eat trees after all, says new study
What constitutes fish food is a matter of debate. A high-profile study a few years ago suggested that fish get almost 50 percent of their carbon from trees and leaves, evidence for a very close link between the terrestrial and aquatic ecosystems.
Half of the fish consumed globally is now raised on farms, study finds
Aquaculture, once a fledgling industry, now accounts for 50 percent of the fish consumed globally, according to a new report by an international team of researchers. And while the industry is more efficient than ever, it is also putting a significant strain on marine resources by consuming large amounts of feed made from wild fish harvested from the sea, the authors conclude.
Study reveals mounting evidence of fish oil's heart health benefits
There is mounting evidence that omega-3 fatty acids from fish or fish oil supplements not only help prevent cardiovascular diseases in healthy individuals, but also reduce the incidence of cardiac events and mortality in patients with existing heart disease.
The 'see food' diet
Current research suggests that a diet high in omega-3 fatty acids may help prevent one of the leading causes of legal blindness among the elderly.
Starve a Fever, Feed a Cold, Don't Be Stressed
Whether it's getting a cold during exam time or feeling run-down after a big meeting, we've all experienced feeling sick following a particularly stressful time at work or school. Is this merely coincidence, or is it possible that stress can actually make us sick?
Edible coating makes fish filets longer-lasting, healthier
Consumers may be able to eat longer-lasting, potentially healthier fish fillets if research at Oregon State University makes its way to the supermarket.
Omega fatty acid balance can alter immunity and gene expression
For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil).
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Kirkland Signature Natural Fish Oil Concentrate with Omega-3 Fatty Acids-400 Softgels by Kirkland Signature Kirkland Signature fish supply comes from deep ocean waters. Our fish oil is not supplied from farm-raised fish. State-of-the-art molecular distillation process is used to remove PCBs and dioxins which guarantees purity and potency. The fish oil is derived from a variety of fish species, to maximize omega-3 fatty acid concentration. Fish Oil naturally contains the Omega-3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
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Coromega Omega-3 Supplement, Orange Flavor, Squeeze Packets, 90-Count Box by Coromega Daily dose squeeze packets. A delicious pudding-like alternative to capsules! Coromega provides superior bioavailability. In clinical study, the Omega-3 in Coromega was shown to enter the bloodstream faster at three times the levels of a fish oil product in softgel form. Each packet of Coromega delivers the daily intake levels of Omega-3 EPA and DHA recommended by experts for adults and children. As Pure As It Is Delicious: Coromega contains premium quality fish oil from deep, cold-water fish; molecular distillation assures product purity. To guarantee freshness and potency, our special packaging system protects the delicate Omega-3 EPA and DHA from oxygen and light a concern with Omega-3 products in bottle. Have you had your Coromega today? Guaranteed DHA & EPA Content. Pharmaceutical... |
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Natrol - Omega-3, 150 softgels by Natrol Each serving of this dietary supplement provides 2 grams of Omega-3 fish oil. Natrol's™ Omega-3 is derived from a variety of select fish and analytically screened to contain less than 1 mg of cholesterol per softgel. |
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Kirkland Signature Fish Oil w/ Omega-3 Fatty Acids, 180 Enteric Coated Softgels by Omega 3 Fatty Acids The enteric coating reduces the fishy odor and aftertaste by protecting the softgel until it reaches the lower intestine. Kirkland Signature fish supply comes from deep ocean waters. Our fish oil is not supplied from farm-raised fish. State-of-the-art molecular distillation process is used to remove mercury, PCBs and dioxins which guarantees purity and potency. Fish Oil naturally contains the Omega3 Fatty Acids, EPA and DHA. Omega-3 Fatty Acids help maintain heart and vascular health.* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
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Source Naturals Essential Fatty Acids (Complete), 120 softgels by Source Naturals Dietary supplement. Source Naturals Complete Essential Fatty Acids is an excellent blend of omega-3 and omega-6 fatty acids. Docosahexaenoic Acid (DHA) is an omega-3 fatty acid which plays a significant role in cerebral development throughout the life style, especially during the crucial period of fetal development and infancy. Gamma-Linolenic Acid (GLA) is an omega-6 fatty acid used by most cells in the body to produce soothing PGE1 prostaglandins. Essential Fatty Acids, or EFA's, act as precursors to molecules such as prostaglandins, thromboxanes and leukotrienes, which help regulate cellular function. EFA's have been shown to play a role in blood pressure maintenance, immune system balance, sustaining healthy skin, and providing nutritional support during women's cycles (These... |
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Nordic Naturals - Omega-3, 180 softgels by Nordic Naturals Nordic Naturals Omega-3 provides an excellent source of omega-3 fatty acids in their naturally existing ratios. Omega-3 fatty acids are needed daily, and must be obtained from our diet. Nordic Naturals Omega-3 is a great tasting, fresh, and pure source of omega-3s and vitamin E. Omega-3s support proper cellular flexibility and cardiovascular health.* Ingredients: purified deep sea fish oil (from anchovies and sardines), soft gel capsule (gelatin, water, glycerin, natural lemon oil), natural lemon oil, d-alpha tocopherol, rosemary extract Each 2 soft gel serving provides: EPA: 330 mg Other Omega-3s: 140 mg DHA: 220 mg Vitamin E (d-alpha tocopherol): 30 IU |
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Weil Nutritional Omega-3 Complex Softgels, 90-Count Bottle by Weil Nutritionals Do I really need to supplement with an omega-3 complex? We all need these healthy fats, which are found primarily in oily fish that live in deep cold water. Research indicates that they promote cardiovascular health while also supporting brain function. Weil Omega-3 Complex is derived from molecularly distilled fish oil that is independently tested for heavy metals (mercury and lead) and other contaminates (including PCBs). Andrew Weil, M.D., donates all his after-tax profits from the sale of Weil Nutritional Supplements to the Weil Foundation, an organization dedicated to sustaining the vision of integrative medicine. |
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Spring Valley - Organic Flaxseed Oil with Omega-3 Fatty Acids 1000 mg, 100 Softgels by Nature's Bounty, Inc. Our Flaxseed Oil is one of the best sources of the Omega-3 fatty acid, alpha-linolenic acid. Through a unique cold processing method, the flaxseeds are pressed at very cold temperatures and are processed without solvents. |
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Kirkland Signature Enteric Coated Fish Oil Omega 3 1200 MG Fish Oil, 684 MG of Omega 3 Fatty Acids, 180 softgels, 5.0-Ounces Bottle by Kirkland Signature |
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The Ultimate Omega-3 Diet: Maximize the Power of Omega-3s to Supercharge Your Health, Battle Inflammation, and Keep Your Mind Sharp by Evelyn Tribole (Author) Live longer, better, and healthier with omega-3s! The Ultimate Omega-3 Diet is the first book to offer simple, practical steps for striking the proper balance between miraculous omega-3 fats and the less-healthy omega-6 fats to get the most out of your diet. Armed with the practical information in The Ultimate Omega-3 Diet, you'll be able to: Discover delicious omega-3-rich foods that are right in your supermarket Cook mouthwatering meals using the 40 included recipes and meal plans Navigate the often-confusing supplements aisle Read food labels to identify hidden omega-6 fats found in many foods Pack in omega-3s even when eating out Learn the omega-3 and omega-6 content of more than 900 foods |
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