 |
|
Inflammation markers linked more with fatal than nonfatal cardiovascular events in elderly
June 23, 2009A study published this week in the open access journal PLoS Medicine shows that for elderly people at risk of cardiovascular disease, the presence of inflammatory markers in the blood can identify that an individual is at a higher risk of a fatal rather than a non-fatal heart attack or stroke.
Inflammation is an immune response to injury. However, inflammation is also thought to play a role in cardiovascular disease. Previous studies have shown an association between high levels of markers of inflammation in the circulation with a greater risk of a cardiovascular event, such as a heart attack or stroke. In this study, Naveed Sattar of the University of Glasgow and colleagues used data from an existing trial known as PROSPER (the Prospective Study of Pravastatin in the Elderly at Risk), which involved participants aged between 70 and 82 who had or were at risk of cardiovascular disease. They examined if three inflammatory markers-interleukin-6 (IL-6), C-reactive protein (CRP) and fibrinogen-were each more strongly massociated with fatal cardiovascular events than with non-fatal cardiovascular events in the period of over three years in which the patients in the trial were monitored.
Using several statistical models, the researchers found that in this group of elderly patients increased levels of all three inflammatory markers, and in particular IL-6, were more strongly associated with a fatal heart attack or stroke than with a non-fatal heart attack or stroke. They also investigated the predictive value of these inflammatory markers-in other words, whether it was useful to include these markers in tools designed to distinguish between individuals with a high and a low risk of heart attacks, strokes and other cardiovascular events. They report that adding IL-6 to the established risk factors in predictive tools-including lifestyle factors such as smoking, high blood pressure and high blood cholesterol, all of which greatly increase the risk of cardiovascular disease-could help better identify those individuals at a risk of a fatal stroke or heart attack, but not those at risk of a non-fatal cardiovascular event.
The findings of the study suggest inflammatory markers may be more strongly associated with fatal heart attacks and strokes than non-fatal cardiovascular events. The researchers acknowledge that these findings now need to be confirmed in younger populations and larger studies to demonstrate an outright association and the design of the current study cannot show whether the proposed association is a causal one. Nevertheless, the findings should stimulate further investigation into whether the application of inflammatory markers may help better predict the risk of deaths from cardiovascular disease, and whether novel treatments which dampen inflammation might help prolong life.
Public Library of Science
The findings of the study suggest inflammatory markers may be more strongly associated with fatal heart attacks and strokes than non-fatal cardiovascular events. The researchers acknowledge that these findings now need to be confirmed in younger populations and larger studies to demonstrate an outright association and the design of the current study cannot show whether the proposed association is a causal one. Nevertheless, the findings should stimulate further investigation into whether the application of inflammatory markers may help better predict the risk of deaths from cardiovascular disease, and whether novel treatments which dampen inflammation might help prolong life.
Public Library of Science
Heart Attack Current Events and Heart Attack News RSSInhibition of GRK2 is protective against acute cardiac stress injuries
Inhibition of a protein known to contribute to heart failure also appears to be protective of the heart in more acute cardiac stress injury, namely ischemia reperfusion.
Vitamin B niacin offers no extra benefit to statin therapy in seniors already diagnosed with CAD
The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.
Heart and bone damage from low vitamin D tied to declines in sex hormones
Researchers at Johns Hopkins are reporting what is believed to be the first conclusive evidence in men that the long-term ill effects of vitamin D deficiency are amplified by lower levels of the key sex hormone estrogen, but not testosterone.
Elevated biomarkers lead to diminished quality of life in heart attack patients post-discharge
Many heart attack patients have high levels of cardiac biomarkers in the blood for several months after leaving the hospital, with more shortness of breath and chest pain, according to a Henry Ford Hospital study.
Tiny particles can deliver antioxidant enzyme to injured heart cells
Researchers at Emory University and the Georgia Institute of Technology have developed microscopic polymer beads that can deliver an antioxidant enzyme made naturally by the body into the heart.
Early end to key study on benefits of niacin, a B vitamin, in keeping arteries open was premature
Heart experts at Johns Hopkins are calling premature the early halt of a study by researchers at Walter Reed Army Medical Center and Washington Hospital Center on the benefits of combining extended-release niacin, a B vitamin, with cholesterol-lowering statin medications to prevent blood vessel narrowing.
oo much selenium can increase your cholesterol
A new study from the University of Warwick has discovered taking too much of the essential mineral selenium in your diet can increase your cholesterol by almost 10%.
Higher carotid arterial stenting rates associated with poorer clinical outcomes
Among eligible Medicare beneficiaries, increased use of carotid arterial stenting (CAS) procedures to treat carotid stenosis-the narrowing of the carotid artery-is associated with higher rates of mortality and adverse clinical outcomes, including heart attack and stroke, according to researchers from the University of Pennsylvania School of Medicine.
Study suggests dentists can identify patients at risk for fatal cardiovascular event
A new study indicates dentists can play a potentially life-saving role in health care by identifying patients at risk of fatal heart attacks and referring them to physicians for further evaluation.
Common Pain Relievers May Dilute Power of Flu Shots
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers - Advil, Tylenol, aspirin - at the time of injection may blunt the effect of the shot and have a negative effect on the immune system.
More Heart Attack Current Events and Heart Attack News Articles
 |
The Cardiac Recovery Handbook: The Complete Guide to Life After Heart Attack or Heart Surgery, Second Edition by Paul Kligfield (Author) Maybe a suspicious angiogram has the doctor suggesting bypass surgery. Maybe a major heart attack has you confined to the ICU. After a heart attack or heart surgery, you have a hundred questions and your family has more. How long will I be in the hospital? What are the side effects of that medication? Why do I feel so depressed? What can I eat? Can I exercise? One of the nation's most respected cardiologists answers all your questions in The Cardiac Recovery Handbook. In clear, everyday language, the book covers all aspects of cardiac recovery—from the initial diagnosis of heart disease to medications and surgical options, from hospitalization to rehabilitation, from diet and exercise to keeping your spirits up. No question is left unanswered. Filled with a wealth of vital... |
 |
Heart Attack Low vs Diamond (Primary Contributor) |
 |
The Last War 1980-84 by Heart Attack |
 |
Heart Attack (A Cleveland Clinic Guide) (Cleveland Clinic Guides) by Curtis Rimmerman (Author) Heart Attack: A Cleveland Clinic Guide There is no other medical center more qualified to write a book on this subject.The Cleveland Clinic Heart Center has been selected as the best Heart Center in America, according to U.S. News & World Report’s annual survey for the past 11 years. Our doctors are leaders in cardiology, cardiac surgery, cardiothoracic anesthesia, and research into the heart and its diseases. No heart program has more experience, more knowledge and better access to technology. As medical pioneers, The Clinic developed cardiac angiography and the coronary artery bypass. One great lesson is that heart disease is a tremendously frustrating condition. It progresses silently and makes its presence known—if at all—only well after it is established in the... |
 |
Zippo Lighter Heart Attack Emblem, Candy Apple Red by Zippo Manufacturing The World Famous Zippo® Guarantee Any Zippo metal product, when returned to our factory will be put in first class condition free of charge, for we have yet to charge a cent for the repair of a Zippo metal product, regardless of age or condition. The finish, however, is not guaranteed. This guarantee gives you specific legal rights and you may also have other rights which vary from state to state. "It works or we fix it for free"? |
 |
The Widow-Maker Heart Attack At Age 48: Written By A Heart Attack Survivor For A Heart Attack Survivor And Their Loved Ones by Patrick J. Fox (Author) The Widow-Maker Heart attack at age 48 was written by a "miracle" survivor of a massive heart attack. He provides hope and a pathway to recovery for other heart attack patients and their loved ones facing the same daunting life changing, unexpected experience. His entire first year of life after suffering his heart attack; actually dying six times, is chronicled in this book combined with his ever changing physical and psychological feelings. In writing this book it was the author's goal to help other families and loved ones facing the same devastating unfamiliar territory as his family faced on March 31, 2008. His goal was to provide timeless support for the loved ones of the heart attack victim so that they might better be able to understand what the patient is going through and what... |
 |
Sweet Dee Has A Heart Attack Also With: FOX (Producer) |
|
Heart Attack Starring: Marcus Allen Cooper Rachel Darden Bennett Directed By: David Harris Also With: David Harris (Producer), David Harris (Writer) A short, romantic comedy from a student filmmaker, "Heart Attack" has been called "romantic and charming" by director of Juno Jason Reitman and honored at such festivals as the Santa Cruz Film Festival and Phoenix Film Festival, among others. Leslie stands in front of a white wall, smiling. She's a pretty girl, happily gazing at us. A narration ensues. This gentle voice describes Leslie's kind attributes and her most basic, yet great, goal: to find her true love. The narrator introduces us to Leslie's boyfriend. We are now in a park, and the narrator describes the scene: Leslie's boyfriend becomes Leslie's ex-boyfriend. Unfortunately, we next look at a moping, tearful Leslie blowing her nose, reading relationship books, and eating ice cream in her bed. She sobs profusely as the... | |
 |
Heart Attack,Candy Apple Red by pachi paradice Purchase this top quality zippo lighter. Makes a great gift. Original zippo. Sure to be loved by anyone |
 |
HEART HEALTHY TIPS by The U.S. Heart Healthy Company Not sure where to start when it comes to improving your heart health? Take some time and create a plan that you can stick to. Include specific goals to eat healthier, exercise more regularly and have a medical physical if it’s been more than a year. |
| © 2009 BrightSurf.com |