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Hepatic encephalopathy and prehepatic portal hypertension rat model
June 29, 2009A research article to be published June 21, 2009 in the World Journal of Gastroenterology addresses this question. The research team lead by Dr. Gabriela Beatriz Acosta, observed that the activity of GS was increased in the hippocampus in PH rats. There was a significant decrease in glutamate uptake in both brain areas, which was more marked in the hippocampus. The decrease in glutamate uptake might be caused by deficient transport function and persistent glutamate activity, which is not metabolized. This leads to severe damage in the cells of the central nervous system (CNS), associated with the presence of moderate ammonia concentration in the blood, as observed in this model. These results demonstrated that partial stricture of the portal vein is able to modify normal function in important areas of the rat brain.
These results suggest that, in PH this pathology, there are differences between both regions of the brain, possibly caused by the toxic metabolic action of ammonia and glutamate, and perhaps glutamine, in the brain, among other factors.
Using this model, it may be possible to understand more clearly the mechanism of toxicity and defense of the brain against the two toxic substances: ammonia and the excitatory neurotransmitter glutamate. The study is important for understanding of some of the mechanisms related to HE.
World Journal of Gastroenterology
World Journal of Gastroenterology
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Hepatic Encephalopathy and Nitrogen Metabolism by D. Häussinger (Editor), G. Kirchels (Editor), F. Schless (Editor) Hepatic encephalopathy is a major complication of liver cirrhosis and acute liver failure and represents an important issue of clinical and socioeconomic relevance. Hyperammonemic syndromes due to inborn errors of metabolism can also trigger encephalopathy. Much effort has been devoted during recent decades to understand the pathogenesis of hepatic encephalopathy, not only at the level of molecular and cell biology, but also at the neurophysiological and neuropsychological level. Considerable advances in the understanding of the syndrome and its relation to nitrogen metabolism have been achieved since the introduction and application of modern techniques of cell and molecular biology, neurophysiology and functional brain imaging, including magnetencephalography, positron emission... |
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Hepatic Encephalopathy by Alan H. Lockwood (Author) A complete monograph on the pathogenesis, neurochemistry, physiology and treatment of hepatic encephalopathy. The book covers the spectrum of topics, including epidemiology, neuropathy, neurophysiology and patient management. State-of-the-art information on altered neurotransmitters is included. | |
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Hepatic Encephalopathy: Syndromes and Therapies by Harold O. Conn (Author), Johannes Bircher (Editor) | |
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Advances in hepatic encephalopathy & metabolism in liver disease by Turkish Gastroenterology Foundation (Publisher) | |
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Hepatic encephalopathy--a serious complication of alcoholic liver disease.: An article from: Alcohol Research & Health by Roger F. Butterworth (Author) This digital document is an article from Alcohol Research & Health, published by U.S. Government Printing Office on March 22, 2003. The length of the article is 2385 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Hepatic encephalopathy--a serious complication of alcoholic liver disease. Author: Roger F. Butterworth Publication: Alcohol Research & Health (Refereed) Date: March 22, 2003 Publisher: U.S. Government Printing Office Volume: 27 Issue: 2 Page: 143(3) Distributed by Thomson... | |
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Hepatic Encephalopathy: Pathophysiology and Treatment (Experimental Biology and Medicine) by Roger F. Butterworth (Author), Gilles Pomier Layrargues (Editor) | |
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Hepatic Encephalopathy, Hyperammonemia and Toxicity (Advances in Experimental Medicine and Biology) by Vicente Felipo (Editor), Santiago Grisolía (Editor) Instituto de Investigaciones Citologicas de la F.I.B., Valencia, Spain. Proceedings of the International Symposium on Cirrhosis, Hyperammonemia and Hepatic Encephalopathy, Valencia, Spain, January 24-27, 1994. | |
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Hepatic Encephalopathy Medical Guide by Qontro Medical Guides (Author) The Hepatic Encephalopathy Medical Guide is a publication which has been designed to better help readers understand Hepatic Encephalopathy. This Qontro Medical Guide has been designed with the reader in mind, and is a useful information source for readers at all levels looking to learn more about Hepatic Encephalopathy. The Hepatic Encephalopathy Medical Guide is highly recommended for those interested in understanding and learning more about Hepatic Encephalopathy. |
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