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Even at High Doses, Gadolinium-Based Contrast Agents Cannot by Themselves Cause Patients to Develop Nephrogenic Systemic Fibrosis
July 01, 2009Even at very high doses, gadolinium-based contrast agents alone are not sufficient to cause nephrogenic systemic fibrosis (NSF) in patients with kidney problems, according to a study performed at the Mayo Clinic Florida, Jacksonville, FL. NSF is a rare and serious syndrome that leads to fibrosis of the skin, joints and even internal organs. Some research indicates NSF is caused by gadolinium-based contrast agents that are commonly used today during MR procedures.
The study examined the records of 61 patients. "Our patients had been given high doses-from two to ten times the usual MRI dose. These high doses were used because the patients were undergoing interventional procedures and the procedures were done before there were any reports linking gadolinium to NSF," said Mellena D. Bridges, MD, lead author of the study.
"Fortunately, one of these patients, a 58-year-old diabetic man with end-stage kidney disease and significant blood vessel blockages, developed NSF. Gadolinium seems to be necessary to trigger NSF, but it doesn't seem to be enough to cause the disease, even at very high doses," said Dr. Bridges.
This study appears in the June issue of the American Journal of Roentgenology.
The American Roentgen Ray Society (ARRS)
This study appears in the June issue of the American Journal of Roentgenology.
The American Roentgen Ray Society (ARRS)
Allergic reactions to gadolinium-based contrast agents are rare, study finds
Allergic-like reactions to gadolinium-containing contrast injections in adults and pediatric patients (those younger than 19 years of age) are rare, according to a recent study conducted by researchers at the University of Michigan Health Systems in Ann Arbor.
MRI contrast agent linked to rare disease
New research has shown a possible association between a popular magnetic resonance imaging (MRI) contrast agent and the incidence of a rare disease called nephrogenic systemic fibrosis (NSF) in patients with kidney disease.
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Cardiovascular MRI: Angiography and Perfusion Studies with I Molar Gadolinium-Based Contrast Agent by Josef Vymazal (Editor) With its high resolution and non-invasive character, contrast-enhanced MR angiography (CE-MRA) is fast becoming a diagnostic method of choice in detecting cardiovascular disease. Additionally, MR scanners can also perform first-pass perfusion studies with contrast agents for the detection and characterization of tissue ischemia. This highly-illustrated text is based on the extensive experience with CE-MRA and perfusion studies by a team of Czech cardiologists and radiologists. They have chosen a practical rather than theoretical approach to apprize the reader of what they need to do when performing MR angiography or perfusion studies with high-concentration contrast agents. |
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