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Double success for Instituto Gulbenkian de Ciencia scientists working on chromosome segregation
July 01, 2009Lars Jansen's work on the formation of the centromere, a key cellular structure in powering and controlling chromosome segregation and accurate cell division, has just earned him a paper in Nature Cell Biology and a prestigious EMBO installation grant, of 50,000 euro per year, for a maximum of five years.
Lars Jansen moved from California to the Instituto Gulbenkian de Ciência (IGC), in Portugal, last year to head the Epigenetic Mechanisms group. The Nature Cell Biology paper, published online this week, in collaboration with a group at Stanford University School of Medicine, provides new insights into the scaffold of proteins that ensures accurate segregation of chromosomes during cell division - a fundamental step to ensure that daughter cells have the same genetic information as their mother, with reduced risk of cancer.
When segregating, chromosomes attach and move along proteins tracks (the mitotic spindle), from the centre of the cell to the poles. The centromere is the area of the chromosome that directs this attachment by controlling the assembly of a scaffold of proteins (called the kinetochore), which tether the chromosome to the spindle, and power its movement along the protein track. The location of the centromere on the chromosome is marked by the presence of a protein, called CENP-A, but how this protein is recognised by the other components of the cell to orchestrate the assembly of the centromere was not understood - until now.
Using a newly developed assay, Lars and his colleagues were able to identify the protein that triggers the assembly of the centromere. It's called CENP-N. According to Mariana Silva, a PhD student in the lab, 'When we depleted CENP-N in cells, the centromere did not assemble correctly and chromosomes segregated abnormally, leading to situations similar to cancer'.
This study, the first paper from Lars and his PhD student Mariana since arriving at the IGC a year ago, proves the applicability of this new assay and open doors to future studies into centromere assembly and structure. Indeed, Lars' proposal to further explore centromere assembly and function, was awarded an EMBO installation grant and entrance into the prestigious network of some of Europe's best young group leaders.
According to Lars, the award "will be a huge boost to our research! Apart from the direct monetary benefit this grant is a great recognition of the relevance of our work and the science we propose in this project. Moreover, entry into the EMBO Young Investigator Programme allows me to fully integrate our emerging laboratory in the larger European scientific community. The IGC has been extremely supportive of our efforts and remains critically important in creating the conditions that help our laboratory and work to come to full fruition."
Portugal is a member state participating in the EMBC, the EMBO intergovernmental funding body and, as such, hosts and fully finances the grants awarded to scientists who wish to establish themselves in this country. This award will be jointly financed by the Portuguese government funding agency, Fundação para a Ciência e a Tecnologia (FCT) and the host institution, the Instituto Gulbenkian de Ciência (IGC), through an agreement established between the Calouste Gulbenkian Foundation and FCT.
This is second time that EMBO rewards projects developed by IGC scientists with this kind of funding. In 2007, Mónica Dias was also awarded an EMBO Installation Grant to pursue her research in regulation of cell cycle progression in normal development and cancer.
Instituto Gulbenkian de Ciencia
Using a newly developed assay, Lars and his colleagues were able to identify the protein that triggers the assembly of the centromere. It's called CENP-N. According to Mariana Silva, a PhD student in the lab, 'When we depleted CENP-N in cells, the centromere did not assemble correctly and chromosomes segregated abnormally, leading to situations similar to cancer'.
This study, the first paper from Lars and his PhD student Mariana since arriving at the IGC a year ago, proves the applicability of this new assay and open doors to future studies into centromere assembly and structure. Indeed, Lars' proposal to further explore centromere assembly and function, was awarded an EMBO installation grant and entrance into the prestigious network of some of Europe's best young group leaders.
According to Lars, the award "will be a huge boost to our research! Apart from the direct monetary benefit this grant is a great recognition of the relevance of our work and the science we propose in this project. Moreover, entry into the EMBO Young Investigator Programme allows me to fully integrate our emerging laboratory in the larger European scientific community. The IGC has been extremely supportive of our efforts and remains critically important in creating the conditions that help our laboratory and work to come to full fruition."
Portugal is a member state participating in the EMBC, the EMBO intergovernmental funding body and, as such, hosts and fully finances the grants awarded to scientists who wish to establish themselves in this country. This award will be jointly financed by the Portuguese government funding agency, Fundação para a Ciência e a Tecnologia (FCT) and the host institution, the Instituto Gulbenkian de Ciência (IGC), through an agreement established between the Calouste Gulbenkian Foundation and FCT.
This is second time that EMBO rewards projects developed by IGC scientists with this kind of funding. In 2007, Mónica Dias was also awarded an EMBO Installation Grant to pursue her research in regulation of cell cycle progression in normal development and cancer.
Instituto Gulbenkian de Ciencia
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Researchers discover mechanism that prevents two species from reproducing
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A solution to Darwin's 'mystery of the mysteries' emerges from the dark matter of the genome
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Common weed could provide clues on aging and cancer
A common weed and human cancer cells could provide some very uncommon details about DNA structure and its relationship with telomeres and how they affect cellular aging and cancer, according to a team led by scientists from Texas A&M University and the University of Cincinnati (UC).
Sex-based prenatal brain differences found
Prenatal sex-based biological differences extend to genetic expression in cerebral cortices. The differences in question are probably associated with later divergences in how our brains develop.
Trembling hands and molecular handshakes
Fragile X tremor/ataxia syndrome (FXTAS) is a recently recognized condition, which is actually one of the most prevalent heritable neurodegenerative diseases.
CSHL-led team discovers rare mutation dramatically increasing schizophrenia risk
An international team of researchers led by geneticist Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL), has identified a mutation on human chromosome 16 that substantially increases risk for schizophrenia.
The first men and women from the Canary Islands were Berbers
A team of Spanish and Portuguese researchers has carried out molecular genetic analysis of the Y chromosome (transmitted only by males) of the aboriginal population of the Canary Islands to determine their origin and the extent to which they have survived in the current population.
Standards for a new genomic era
A team of geneticists at Los Alamos National Laboratory, together with a consortium of international researchers, has recently proposed a set of standards designed to elucidate the quality of publicly available genetic sequencing information.
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