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Developing a safer form of acetaminophen
July 16, 2009Organic Process Research & Development
Scientists in Louisiana are reporting development of a process for producing large batches of a new and potentially safer form of acetaminophen, the widely used pain-reliever now the source of growing concern over its potentially toxic effects on the liver. Their study, which could speed development of a next-generation pain-reliever, is scheduled for the July 17 issue of ACS' Organic Process Research & Development, a bi-monthly journal.
In June, an advisory panel of the U. S. Food and Drug Administration recommended banning certain prescription pain relievers containing acetaminophen because of the drug's potential to cause liver damage when used in high doses. Mark Trudell and colleagues note in the study that scientists recently discovered a new form of acetaminophen that has similar potency to the original drug with a lower risk of liver toxicity. But until now, scientists have had difficulty producing this substance in quantities suitable for industrial scale-up.
The researchers describe a simple, efficient method for producing the new pain-reliever using only a few starting materials and a short series of chemical reactions. In laboratory studies, they used the new method to produce multigram quantities of the substance with 99 percent purity. The scientists point out that the new process can be performed on a much larger production level if needed.
American Chemical Society
American Chemical Society
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Common Pain Relievers May Dilute Power of Flu Shots
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers - Advil, Tylenol, aspirin - at the time of injection may blunt the effect of the shot and have a negative effect on the immune system.
Medication effective for acute liver failure in early stages of disease
The antidote for acute liver failure caused by acetaminophen poisoning also can treat acute liver failure due to most other causes if given before severe injury occurs, UT Southwestern Medical Center researchers and their colleagues at 21 other institutions have found.
Marshall research shows safe dosages of common pain reliever may help prevent muscle loss and other conditions related to aging
Recent studies conducted by Dr. Eric Blough and his colleagues at Marshall University have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions.
Ibuprofen is as effective as acetaminophen with codeine to treat pain in children with arm fractures
Children with arm fractures fared as well with ibuprofen to control their pain as acetaminophen with codeine, according to a new study by researchers at the Medical College of Wisconsin, Milwaukee, and Children's Research Institute.
UNC study: new approach promises greater success for predicting drug safety
A new UNC study published online in the journal Genome Research describes a new, more effective and less costly method for testing drugs for potential toxicity and one that could also result in more people benefiting from existing drugs.
What teens don't know about OTC medications can hurt them
Teens, who are starting to make more decisions about their own health care, may not know enough about over-the-counter pain medications to avoid complications or inadvertent misuse.
Oxycodone effective against shingles pain
The painkiller oxycodone is effective at treating the acute pain of shingles, an illness that often causes severe pain which can become long-lasting and sometimes even permanent.
Acute gastric injury due to high-dose analgesics?
Analgesics, NSAIDs and acetaminophen, are commonly used for the relief of fever, headaches, and other minor aches and pains. The gastrointestinal side effects of NSAIDs are well documented and acetaminophen is accepted to be a safe drug for the gastrointestinal system. Acute effects of short-term, especially high-dose NSAID and acetaminophen use have not been studied adequately.
Antibiotics: Single largest class of drugs causing liver injury
Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI), reports a new study in Gastroenterology, an official journal of the American Gastroenterological Association (AGA) Institute.
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