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Pinhead-size worms + robot = new antibiotics
August 06, 2009In an advance that could help ease the antibiotic drought, scientists in Massachusetts are describing successful use of a test that enlists pinhead-sized worms in efforts to discover badly needed new antibiotics. Their study appeared in ACS Chemical Biology, a monthly journal.
Frederick Ausubel and colleagues note in the new study that existing methods for identifying germ-fighting drugs involve adding the potential drug to cultures of bacteria or cells and watching the results. These tests sometimes do not work well. They may give passing grades to potential drugs that are toxic, or that fight bacteria in the same ways as existing antibiotics that are loosing effectiveness against drug-resistant bacteria. A much better test would involve screening of potential new antibiotics in living animals infected with bacteria to see the effects on the entire body of the animal.
The scientists describe successful use of such a whole-animal high throughput screening test - automated with a robot - to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threatening infections in humans. C. elegans are tiny nematode worms that are widely used in scientific research. The tests identified 28 potential new drugs never before reported to have germ-fighting effects. Some of the potential new drugs worked in ways that appeared to be totally different than existing antibiotics.
American Chemical Society
American Chemical Society
Antibiotics Current Events and Antibiotics News RSSA Second Skin
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Study reveals why certain drug combinations backfire
Combination drug therapy has become a staple for treating many infections. For instance, doctors treat extensively drug resistant forms of tuberculosis with one drug that breaks down the pathogen's protective barriers and opens the door for another to deliver the deathblow.
New imagining technique could lead to better antibiotics and cancer drugs
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UCLA researchers reconstitute enzyme that synthesizes cholesterol drug lovastatin
Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin.
Progress made on group B streptococcus vaccine
Scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have completed a Phase II clinical study that indicates a vaccine to prevent Group B Streptococcus (GBS) infection is possible.
Henry Ford Hospital study: A MRSA strain linked to high death rates
A strain of MRSA that causes bloodstream infections is five times more lethal than other strains and has shown to have some resistance to the potent antibiotic drug vancomycin used to treat MRSA, according to a Henry Ford Hospital study.
Bacteria 'launch a shield' to resist attack
Researchers from the University of Copenhagen and the Technical University of Denmark along with other collaborators in Denmark and the US found that the bacterium Pseudomonas aeruginosa can 'switch on' production of molecules that kill white blood cells - preventing the bacteria being eliminated by the body's immune system.
Pumpkin skin may scare away germs
The skin of that pumpkin you carve into a Jack-o'-Lantern to scare away ghosts and goblins on Halloween contains a substance that could put a scare into microbes that cause millions of cases of yeast infections in adults and infants each year.
Deadly stomach infection rising in community settings, Mayo Clinic study finds
Mayo Clinic researchers have found that a sometimes deadly stomach bug, Clostridium difficile is on the rise in outpatient settings.
New clinical guidelines for exacerbations in cystic fibrosis
The American Thoracic Society has released new clinical guidelines for the treatment of exacerbations in cystic fibrosis based on a review of the literature on current clinical practices.
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Fish Mox (Amoxicillin 250 mg) - 100 Caps by THOMAS LABS Fish-Mox exerts a bactericidal action on gram positive and some gram negative bacteria. Useful for control of some common bacterial diseases of fish including aeromonas and pseudomonas genera and mysobacterial group (gill diseases, chondrococcus). Add contents of one capsule (250 mg) into aquarium for each 10 gallons of water to be treated. Repeat in 24 hours. It is suggested that a partial water change be made between treatments. While duration of treatment depends on type and severity of infection, it is recommended that extended medication baths continue for a minimum of 5 days & for not more than 10 days. Discontinue treatment if no improvement is noted within 5 days. To remove harmless yellow color, change 20% of water and use charcoal filter until clear. |
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Antibiotics Pocketcard 2009 by H. Hof (Author) Antibiotics pocketcard provides an initial choice of antimicrobial therapy for most common infections. These empirical therapies cover more than 90% of everyday scenarios. The reverse side of this durable plastic card shows a table of antimicrobial spectra for the most important antibiotics. **2009 edition, completely updated! **Initial choice of antimicrobials for: CNS, heart, blood, gastrointestinal tract, bones/joints, urogenital tract, eye, ENT, skin/soft tissue diseases, fever of unknown origin. **Antimicrobial agents against selected bacteria, e.g. streptococci, staphylococci. |
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First Aid Only Triple Antibiotic Ointment Pack, 0.5 Gram, 25-Count Boxes (Pack of 3) by First Aid Only Use this triple antibiotic ointment pack to treat all kinds of minor cuts, burns and abrasions. Helps prevent infection while it promotes healing. May be applied 2 to 3 times daily as the condition indicates. Active ingredients: neomycin and polymyxin B sulfates and bacitracin zinc ointment USP. |
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Neosporin Plus Pain Relief First Aid Antibiotic/Pain Relieving Cream, Maximum Strength 0.5-Ounce Tubes (Pack of 4) by Neosporin This first-aid antibiotic and pain relief cream helps soothe painful cuts, scrapes and burns while preventing infection. Contains neomycin sulfate, polymyxin B sulfate, and pramoxine HCI. Maximum strength pain relief formula. Doctor-recommended brand. |
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