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Gallbladder emptying in primary sclerosing cholangitis patients
August 10, 2009Primary sclerosing cholangitis (PSC) is an idiopathic chronic cholestatic inflammatory liver disease characterized by diffuse fibrosing inflammation of intra- and/or extrahepatic bile ducts, resulting in bile duct obliteration, biliary cirrhosis, and eventually hepatic failure. One of the most common symptoms at the time of presentation of PSC is mild to severe abdominal pain localized in the right upper quadrant. However, the mechanisms responsible for the abdominal pain in PSC are not fully understood.
A research team led by Karouk Said from Karolinska University Hospital addressed this question. Their study will be published on July 28, 2009 in the World Journal of Gastroenterology.
In this study, 20 patients with PSC and 10 healthy subjects were investigated. Gallbladder fasting volume, ejection fraction and residual volume after ingestion of a test meal were compared in patients with PSC and healthy controls using magnetic resonance imaging. Symptoms, thickness and contrast enhancement of the gallbladder wall and the presence of cystic duct strictures were also assessed.
Median fasting gallbladder volume in patients with PSC [67 (19-348) mL] was twice that in healthy controls [32 (16-55) mL] (P < 0.05). The median postprandial gallbladder volume in patients with PSC was significantly larger than that in healthy controls (P < 0.05). There was no difference in ejection fraction, gallbladder emptying volume or mean thickness of the gallbladder wall between PSC patients and controls. Contrast enhancement of the gallbladder wall in PSC patients was higher than that in controls; (69% ± 32%) and (42% ± 21%) (P < 0.05). No significant association was found between the gallbladder volumes and occurrence of abdominal pain in patients and controls.
This concluded that PSC patients have increased fasting gallbladder volume. Gallbladder mucosal dysfunction secondary to chronic cholecystitis, may be a possible mechanism for increased gallbladder volume. Gallbladder size or emptying does not seem to be involved in the development of abdominal pain in patients with PSC.
World Journal of Gastroenterology
Median fasting gallbladder volume in patients with PSC [67 (19-348) mL] was twice that in healthy controls [32 (16-55) mL] (P < 0.05). The median postprandial gallbladder volume in patients with PSC was significantly larger than that in healthy controls (P < 0.05). There was no difference in ejection fraction, gallbladder emptying volume or mean thickness of the gallbladder wall between PSC patients and controls. Contrast enhancement of the gallbladder wall in PSC patients was higher than that in controls; (69% ± 32%) and (42% ± 21%) (P < 0.05). No significant association was found between the gallbladder volumes and occurrence of abdominal pain in patients and controls.
This concluded that PSC patients have increased fasting gallbladder volume. Gallbladder mucosal dysfunction secondary to chronic cholecystitis, may be a possible mechanism for increased gallbladder volume. Gallbladder size or emptying does not seem to be involved in the development of abdominal pain in patients with PSC.
World Journal of Gastroenterology
Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease
A new study shows that an imaging technology developed by Mayo Clinic researchers can identify liver fibrosis with high accuracy and help eliminate the need for liver biopsies. Liver fibrosis is a common condition that can lead to incurable cirrhosis if not treated in time.
Children's Hospital 1 of 10 pediatric hospitals in US selected to study liver disease in kids
Children's Hospital of Pittsburgh of UPMC has been selected to join an effort among select centers in the United States and Canada to collect and study information necessary to understand the possible causes and treatment of a destructive liver disease called primary sclerosing cholangitis (PSC).
Correlation between bile duct obstruction and ductal cancer found
When bile duct cancer cells were placed in the liver of animals with bile duct obstruction, they grew more rapidly than identical cells placed in animals without bile duct obstruction.
Rare Domino Transplant Allows Children's Hospital of Pittsburgh and UPMC Surgeons to Save Two Lives With One Deceased Donation
Transplant surgeons at Children's Hospital of Pittsburgh and UPMC have saved two patients with life-threatening liver conditions utilizing a technique known as a domino transplant. It is only the nation's second domino transplant involving a patient with maple syrup urine disease (MSUD).
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The Official Patient's Sourcebook on Primary Sclerosing Cholangitis: A Revised and Updated Directory for the Internet Age by Icon Health Publications (Author) This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to primary sclerosing cholangitis (also Chronic Obliterative Cholangitis; Fibrosing Cholangitis; Primary sclerosing cholangitis; Stenosing Cholangitis), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official... |
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Primary Sclerosing Cholangitis Awareness Ribbon Mouse Pad by MyHeritageWear.com The Primary Sclerosing Cholangitis proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Primary Sclerosing Cholangitis than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Primary Sclerosing Cholangitis mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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Ulcerative Colitis: Treatment of ulcerative colitis, Biological therapy for inflammatory bowel disease, Ileo-anal pouch, Ileostomy, Inflammatory bowel disease, Primary sclerosing cholangitis by John McBrewster (Editor), Frederic P. Miller (Editor), Agnes F. Vandome (Editor) Ulcerative colitis. Treatment of ulcerative colitis, Biological therapy for inflammatory bowel disease, Ileo-anal pouch, Ileostomy, Inflammatory bowel disease, Primary sclerosing cholangitis, Colitis, Pseudomembranous colitis, Fecal bacteriotherapy, Helminthic therapy |
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CLINICS IN LIVER DISEASE: Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and Adult Cholangiopathies by W. B. Saunders Co. (Publisher) |
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Cholestatic Liver Disease (Clinical Gastroenterology) by Keith D. Lindor (Editor), Jayant A. Talwalkar (Editor) Over the past two decades, there has been a steady increase in knowledge associated with the clinical manifestations of cholestatic liver disease. In addition to a growing amount of information on the well-studied disorders of primary biliary cirrhosis and primary sclerosing cholangitis, there has been a rapid accumulation of data on less well-known but important topics such as overlap syndromes with autoimmune hepatitis, cholestatic variants of alcohol and viral disease, and cholestasis following liver transplantation. These emerging insights are complemented by further improvements of the diagnosis and management of cholestasis. Based on these clinical situations, "Cholestatic Liver Disease" provides essential information for individuals involved in the care of patients affected by... |
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