Predictors of disease behavior change in Crohn's diseaseAugust 10, 2009Using the Vienna classification system, it has been shown in clinic-based cohorts that there can be a significant change in disease behavior over time, whereas disease location remains relatively stable. Clinical and environmental factors as well as medical therapy might be relevant in predicting disease behavior change in patients with CD. In previous studies, early age at diagnosis, disease location, perianal disease and, in some studies, smoking were associated with the presence of complicated disease and surgery. The combined effect of markers of disease phenotype (e.g., age, gender, location, perianal diesease) and medical therapy (steroid use, early immunosupression) on the probability of disease behavior change were, however, not studied thus far in the published literature. A research article to be published on July 28, 2009 in the World Journal of Gastroenterology addresses this question. Members of the Hungarian IBD Study Group led by Dr Peter Laszlo Lakatos from the Semmelweis University investigated 340 well-characterized, unrelated, consecutive CD patients (M/F: 155/185, duration: 9.4 ± 7.5 years) with a complete clinical follow-up. Medical records including disease phenotype according to the Montreal classification, extraintestinal manifestations, use of medications and surgical events were analyzed retrospectively. Patients were interviewed on their smoking habits at the time of diagnosis and during the regular follow-up visits. They found that perianal disease, current smoking, prior steroid use, early azathioprine or azathioprine/biological therapy are predictors of disease behavior change in CD patients. The new data with easily applicable clinical information as presented in the article may assist clinicians in practical decision-making or in choosing the treatment strategy for their CD patients. World Journal of Gastroenterology |
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| Related Behavior Change Current Events and Behavior Change News Articles Addressing obesity via the 'energy gap' The November issue of the Journal of the American Dietetic Association features a commentary by James O. Hill, an honorary ADA member, professor of pediatrics and medicine and director of the Center for Human Nutrition at the University of Colorado-Denver. Healthy neighborhoods may be associated with lower diabetes risk Individuals living in neighborhoods conducive to physical activity and providing access to healthy foods may have a lower risk of developing type 2 diabetes in a five-year period, according to a report in the October 12 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. Child safety seat education needs an extra boost Motor vehicle crashes are a leading cause of death among children despite the widespread availability of effective child passenger restraint systems (CPRSs) such as child safety seats. Walking often and far reduces risks in heart patients An exercise program that burns a lot of calories reduced cardiac risk factors better than standard cardiac rehabilitation in overweight coronary patients, researchers report in Circulation: Journal of the American Heart Association. UCSF study shows attitudes toward tobacco industry linked to smoking behavior A new study by UCSF researchers concludes that media campaigns that portray the tobacco industry in a negative light and that appeal to young adults may be a powerful intervention to decrease young adult smoking. Weight Loss Reduces Incontinence for Women Starting a weight-loss regimen significantly reduces urinary incontinence for women, according to researchers at the University of Alabama at Birmingham (UAB) and the University of California, San Francisco. The key to a healthy lifestyle is in the mind The main factors influencing the amount of physical exercise people carry out are their self-perceived ability and the extent of their desire to exercise. Community-based behavior change management cuts neonatal mortality in half A community-based program that reinforces basic childbirth and newborn care practices can reduce a baby's risk of death within the first month of life by as much as 54 percent, according to a study in rural India led by researchers at the Johns Hopkins Bloomberg School of Public Health in collaboration with CSM Medical University in Lucknow, India. Is that song sexy or just so-so? Why is your mate's rendition of Marvin Gaye's "Let's Get it On" cute and sexy sometimes and so annoying at other times? A songbird study conducted by Emory University sheds new light on this question, showing that a change in hormone levels may alter the way we perceive social cues by altering a system of brain nuclei, common to all vertebrates, called the "social behavior network." Walk your way to a healthier lifestyle Need a boost to get off the couch? A new study shows that a variety of interventions designed to promote walking can effectively motivate individuals to initiate walking behaviors. The results of the review are published in the July issue of Medicine & Science in Sports and Exercise. More Behavior Change Current Events and Behavior Change News Articles |
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