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Metabolic bone disease in cirrhosis patients
August 10, 2009Long-standing liver disease has long been recognized to result in fragile bones with increased risk of fractures. In various international studies, the overall incidence has varied from 11% to 48%, with a fracture rate of 3%-44%. However, the reason for this is poorly understood. With liver transplantation becoming a viable option in liver disease and offering complete cure and long-term survival, bone disease is becoming the major determinant of survival and quality of life in these patients.
A research article to be published on July 28, 2009 in the World Journal of Gastroenterology addresses this question. This research team was led by Tushar R Bandgar from KEM Hospital, India.
They found that low bone formation and increased resorption led to fragile bones in these patients. Contributing factors identified were inadequate sunlight exposure, reduced physical activity, low body weight, vitamin D deficiency and low level of testosterone. They also demonstrated that the severity of bone loss was accelerated in patients with low IGF-1 level. IGF-1 is normally synthesized in the liver and its synthesis is affected early in cirrhosis. The present study also found that the increased estrogen level seen in cirrhosis was protective against osteopenia.
These results shed new light on bone disorders seen in patients with cirrhosis. As most of the factors identified are correctable or treatable, it should provide additional help in treatment of these patients, such that they have better quality of life and survival.
World Journal of Gastroenterology
These results shed new light on bone disorders seen in patients with cirrhosis. As most of the factors identified are correctable or treatable, it should provide additional help in treatment of these patients, such that they have better quality of life and survival.
World Journal of Gastroenterology
Cirrhosis Current Events and Cirrhosis News RSSToward explaining why hepatitis B hits men harder than women
Scientists in China are reporting discovery of unusual liver proteins, found only in males, that may help explain the long-standing mystery of why the hepatitis B virus (HBV) sexually discriminates -- hitting men harder than women.
Unexplained liver hemorrhage after metastasis radiofrequency ablation
Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved.
The use of stem cells in regenerative medicine may also be detrimental for health
The use of stem cells in regenerative medicine is not always beneficial for human health, it may even be harmful according to a work done by the University of Granada and University of León. Scientists have demonstrated that transplantation of human mononuclear cells isolated from umbilical cord blood exerted a deleterious effect in rats with liver cirrhosis.
Alcohol Tolerance Switch Found in Fruit Flies
Researchers at North Carolina State University have found a genetic "switch" in fruit flies that plays an important role in making flies more tolerant to alcohol.
UCSD researchers pave the way for effective liver treatments
A combination of bioengineering and medical research at the University of California, San Diego has led to a new discovery that could pave the way for more effective treatments for liver disease.
Discovery could improve hepatitis C treatment
Walter and Eliza Hall Institute researchers are part of an international team that has discovered a genetic variation that could identify those people infected with hepatitis C who are most likely to benefit from current treatments.
What are the risk factors for rebleeding after negative angiography?
Acute non-variceal gastrointestinal bleeding accounts for approximately 20% of emergency room visits and 5% of admissions.
HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia?
Previous studies revealed that HBV genotypes as well as mutations in the core promoter, precore or HBx gene have been shown to have an association with the clinical outcome of liver disease, however, this is still controversial.
Is endotoxin receptor CD14 rs2569190/C-159T gene correlated with chronic hepatitis C?
It is still unknown why the natural history of chronic disease caused by hepatitis C virus (HCV), which currently infects 3% of the world's population, varies from mild in some patients to rapidly progressing in others.
Hepatitis C virus channels efforts into cell survival
Researchers at the University of Leeds have discovered a previously unknown mechanism that allows the hepatitis C virus (HCV) to remain in the body for decades.
More Cirrhosis Current Events and Cirrhosis News Articles
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The First Year: Cirrhosis: An Essential Guide for the Newly Diagnosed (First Year, The) by James L. Dickerson (Author), Fredric Regenstein (Foreword) More than 25 million Americans and 92 million worldwide suffer from liver disease and cirrhosis, a degenerative and potentially fatal condition in which liver cells are damaged and then replaced by scar tissue, impeding liver function. The disease is most commonly caused by excessive alcohol consumption, hepatitis, or complications from prescription drugs. Immediately after his diagnosis, James Dickerson set out to educate himself on all of his options — and found there is hope for recovery. Now, he offers The First Year: Cirrhosis, the first guide for patients and their families to understanding and managing this chronic condition. In clear, accessible language, the book walks readers step-by-step through everything they need to do each day of the first week after a cirrhosis... |
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The Official Patient's Sourcebook on Cirrhosis of the Liver: A Revised and Updated Directory for the Internet Age by ICON Health Publications (Author) This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to cirrhosis of the liver (also liver cirrhosis), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on cirrhosis of the liver. Given patients' increasing sophistication in using... |
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The Liver Book: A Comprehensive Guide to Diagnosis, Treatment, and Recovery by Sanjiv Chopra (Author) It is the portal to total body wellness, the great purifier, and the only human organ that can regenerate itself. But what you don't know about the liver can hurt you! Now, in this complete and authoritative guide that anyone can use and understand, Dr. Sanjiv Chopra explains: The what, where, how, and why of the liver and its miraculous functions |
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The Official Patient's Sourcebook on Primary Biliary Cirrhosis by James N. Parker (Editor), Philip M. Parker (Editor) This book has been created for patients who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells patients where and how to look for information covering virtually all topics related to primary biliary cirrhosis (also Cholangiolitic biliary cirrhosis; Hanot syndrome; Hypertrophic cirrhosis of Hanot), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on primary... |
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Dr. Melissa Palmer's Guide To Hepatitis and Liver Disease by Melissa Palmer (Author) In the United States alone, more than four million people are infected with the hepatitis C virus, and chronic liver disease is the twelfth leading cause of death. In this revised and updated edition of her groundbreaking 2000 book, renowned hepatologist Dr. Melissa Palmer discusses all facets of liver disease, from symptoms and tests to treatment options and lifestyle changes. In addition, this comprehensive handbook reveals cutting-edge research on the dangers of hepatitis C, one of the world's fasting-growing microbial threats. |
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Hot and Cold Health by Richard G. Heft (Author) Hot and Cold Health. written for the layman, is based on traditional Chinese and Ayurvedic medicines and the questioning and counseling of 10,000+.. Life, health, disease, happiness, sadness, etc. are a function of body, mind and spirit (soul of God). The body balances opposites, builds up (hot, yang) and breaks down, cleanses (cold, yin), largely according to food, nutrients, to which, there are only two: building and cleansing. Too much or too little building or cleansing, in the extreme, tends to cause disease via too much or too little blood, structure and function. Simple diet, common foods and herbs can prevent and or cure most physical disease. It cannot cure mental disease, which is the root cause of all disease as the mind thinks, makes all the decisions, choices: diet,... |
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A Dog Called Cirrhosis [Explicit] Brzowski & Moshe (Primary Contributor) |
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Milk Thistle 175mg - 60 - Capsule by Bluebonnet MILK THISTLE EXTRACT 175 mg. Vcaps Pure Indena® milk thistle seed extract imported from Europe. Including e - d - s, an enzyme delivery system from 100% plant sources. Available in easy-to-swallow vegetable capsules for maximum assimilation and absorption. |
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Alcoholic Death Noise by Cirrhosis | |
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Primary Biliary Cirrhosis Awareness Ribbon Mouse Pad by MyHeritageWear.com The Primary Biliary Cirrhosis Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Primary Biliary Cirrhosis Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Primary Biliary Cirrhosis Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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