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Sequential TACE and cryosurgery can improve survival times for patients with HCC?
August 12, 2009Hepatocellular carcinoma (HCC)--a liver cancer--is recognized as one of the most common cancers in the world that disproportionately affects Southeast Asians and Africans. While there are therapies that possibly provide a cure, surgical removal and liver transplantation are invasive and radical options. However, even these approaches only benefit a small proportion of the total number HCC patients. Cryosurgery is a minimally invasive technique of using extreme low temperatures to freeze and kill tumors, improve patient' survival times, and reduce surgical complications. Cryosurgery can be potentially applied to any surgery for solid organ cancers where conventional surgery would otherwise be used to remove undesirable tissue. It is anticipated that in the near future, cryosurgery will increasingly replace the use of traditional techniques of ablation.
A research article discussed will be published on August 7, 2009 in the World Journal of Gastroenterology. This article will address the best method to treat HCC which can not be removed by operation. The findings of this study are significant to the procedures that are performed daily at Fuda Cancer Hospital Guangzhou, and will hopefully change the practices at other cancer centers as well.
TACE is based on the fact that normal liver gets its blood supply from two sources: the portal vein (about 70%) and the hepatic artery (30%). HCC gets its blood exclusively from the hepatic artery. TACE works by sending a catheter up the hepatic artery and its branch, and then injecting embolic material. Embolization blocks the tumor-feeding vessels and leads to cancer cell death and tumor shrinkage. Without this procedure, the hepatic artery and branches would continue to feed the liver tumor and allowing it to continue growing.
TACE performed prior to cryoablation may be expected to increase the efficacy of the cryoablation for HCC, to decrease local recurrence at the ablation area, improve survival times, and reduce bleeding complications. Cryosurgery combined with TACE, allows a broader group patients with HCC to be treated. Previously, only a small portion of HCC patients could be treated with conventional methods; even then, only those with small tumors. If TACE is performed prior to cryosurgery, more patients can be treated, even those with larger tumors.
World Journal of Gastroenterology
TACE performed prior to cryoablation may be expected to increase the efficacy of the cryoablation for HCC, to decrease local recurrence at the ablation area, improve survival times, and reduce bleeding complications. Cryosurgery combined with TACE, allows a broader group patients with HCC to be treated. Previously, only a small portion of HCC patients could be treated with conventional methods; even then, only those with small tumors. If TACE is performed prior to cryosurgery, more patients can be treated, even those with larger tumors.
World Journal of Gastroenterology
Hepatocellular Carcinoma Current Events and Hepatocellular Carcinoma News RSSPromising novel treatment for human cancer -- Chrysanthemum indicum extract
A series of studies have demonstrated that Chrysanthemum indicum possesses antimicrobial, antiinflammatory, immunomodulatory, and neuroprotective effects.
M. D. Anderson examines use of toad venom in cancer treatment
Huachansu, a Chinese medicine that comes from the dried venom secreted by the skin glands of toads, has tolerable toxicity levels, even at doses eight times those normally administered, and may slow disease progression in some cancer patients, say researchers from The University of Texas M. D. Anderson Cancer Center.
HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia?
Previous studies revealed that HBV genotypes as well as mutations in the core promoter, precore or HBx gene have been shown to have an association with the clinical outcome of liver disease, however, this is still controversial.
Is RTA a new potential option for the treatment of hydatid cysts?
Current treatment of cystic echinococcosis is surgery or percutaneous aspiration, injection and reaspiration (PAIR) using hypertonic saline or ethanol.
Targeting Tumor Behavior May Lead To New Liver Cancer Drugs
Ohio State University cancer researchers have used computational and genomic methods to identify possible anti-cancer agents that may block a particular kind of tumor behavior.
What is the relationship between hepatocellular carcinoma and type 2 diabetes mellitus?
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and the third leading cause of cancer-related deaths.
Low-fat diet helps genetically predisposed animals avoid liver cancer
In a study comparing two strains of mice, one susceptible to developing cancer and the other not, researchers found that a high-fat diet predisposed the cancer-susceptible strain to liver cancer, and that by switching to a low-fat diet early in the experiment, the same high-risk mice avoided the malignancy.
Study indicates cancer preventive effect for statins
The commonly used prescription statin drugs may have a protective effect in the prevention of liver cancer and lead to a reduction in the need for gallbladder removals, according to two studies published in Gastroenterologyiption statin drugs may have a protective effect in the prevention of liver cancer and lead to a reduction in the need for gallbladder removals, according to two studies published in Gastroenterology.
Is telmisartan effective in treating non-alcoholic steatohepatitis?
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are well-recognized causes of progressive liver disease leading to cirrhosis and hepatocellular carcinoma.
Targeting the protein AEG1 impairs human liver cancer growth in mice
Hepatocellular carcinoma (HCC) is a highly aggressive form of liver cancer and one of the 5 most common cancers worldwide. Devanand Sarkar and colleagues, at Virginia Commonwealth University School of Medicine, Richmond, have now identified a gene that is expressed at high levels in human HCC tumor samples and generates a protein important for HCC progression.
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Hepatocellular Carcinoma by W. Y. Lau (Author), W. Y. Lau (Editor) This essential book is a compendium of papers written by an international team of world-renowned experts, who cover topics in their respective areas of expertise. Presenting the most up-to-date knowledge of hepatocellular carcinoma, it covers all topics -- including those more controversial ones -- in this rapidly advancing field, from epidemiology to prevention, from molecular biology to gross pathology, from screening to atypical presentation, from diagnosis to treatment, and from assessment to choice of appropriate treatment. This volume is therefore an important contribution to the field of hepatocellular carcinoma. Contents: Epidemiology (T Y-M Leong & A S-Y Leong); Assessment of Liver Function (D V Mann); Prevention (M C Kew); Screening (M Sherman); Tumor Markers (J Y H... |
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Surgsat: Professional Video Journal in General Surgery Volume II: 11:21 Liver Resection for Hepatocellular Carcinoma, 11:22 Operative Treatment of Cancer of the Colon, 11:23-24 The Technique of Total Thyroidectomy c1986 Video tape. John L. Cameron, M.D., editor. The John Hopkins Medical Institutions. CME-SAT. | |
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5th International Meeting Hepatocellular Carcinoma- Eastern and Western Experiences - 2007- DVD1 Also With: The University of Texas - MD Anderson Cancer Center (Host) DVD 01- Treatment of HCC Yesterday and Today Surgery for HCC: an Eastern Perspective M. Makuuchi, MD Surgery for HCC: a Western Perspective J. Belgheti, MD Interstitial Therapy for HCC T. Livraghi, MD |
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Hepatocellular Carcinoma: Diagnosis and Treatment (Current Clinical Oncology) by Brian I. Carr (Editor) Hepatocellular cancer is the fifth most common cancer, with 600,000 new cases reported each year worldwide. Additionally, exciting changes in the science of HCC in the last four years have turned the practice of diagnosing and treating the disease upside down. In Hepatocellular Carcinoma: Diagnosis and Treatment, Second Edition, the leading experts in the field of HCC thoroughly update and expand upon the critically acclaimed first edition with all the latest developments in the diagnosis and treatment of primary liver cancer. The book details for physicians the diagnostic and therapeutic decision making process for dealing with such problems as incidental tumors in the liver transplant, the role of neo-adjuvant chemotherapy, intra-arterial vs intravenous therapy, the uses of... |
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Diagnosis and Treatment of Hepatocellular Carcinoma by Tito Livraghi (Editor), Masatoshi Makuuchi (Editor), Luigi Buscarini (Editor) The book is edited by a multidisciplinary team, with an international group of contributors. After discussing the basic and clinical aspects of HCC the main focus of the book is on diagnosis and therapy. The book is both authoritative and practical, providing expert guidance on the various techniques used in diagnosis, such as ultrasound, CT and MRI and the appropriate therapeutic options, for example, surgical resection, transcatheter therapies and radiofrequency ablation. It is fully illustrated throughout in both colour and black and white. |
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5th International Meeting Hepatocellular Carcinoma- Eastern and Western Experiences - 2007 DVD 03 Symposium: Large HCC (> 5cm) Chairpersons: J. Belgethi, S.A. Curley, W.C. Chapman Surgical Resection J. N. Vauthey Liver Transplantation in Patients with and without Chronic Liver Disease P. Neuhaus Nonsurgical Treatment T. W T. Leung |
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Hepatocellular Carcinoma: A Practical Approach by Bandar Al Knawy (Author) An essential resource for gastroenterologists, hepatologists, liver surgeons, hepatobiliary surgeons, oncologists, and all those working in the field of hepatocellular carcinoma (HCC), Hepatocellular Carcinoma: A Practical Approach covers the updates and recent developments on the diagnosis, screening, and comprehensive medical and surgical management of HCC. This one-of-a-kind textbook explores all aspects of the disease using a practical, evidence-based approach, and provides step-by-step treatment guidelines that are applicable to all clinical scenarios. Highlights in the text include: screening and surveillance methods to aid in the prevention of HCC imaging technologies for accurate diagnosis, including ultrasound and... |
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5th International Meeting Hepatocellular Carcinoma- Eastern and Western Experiences 2007- DVD 02 Also With: The University of Texas - MD Anderson Cancer Center (Host) Symposium: Early HCC (< 2cm) Chairpersons: M. Makuuchi, C. Charnsangavej, K.Ahrar Imaging of Dysplastic Nodules and Early HCC B. Taouli,MD Dysplastic Nodules vs. Early HCC: The Eastern Perspective M. Kojiro, MD Dysplastic Nodules vs. Early HCC: The Western Perspective G.Y. Lauwers, MD Therapy: Resection, Radiofrequency Ablation, or Transplantation T. Takayama, MD |
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Hepatocellular Carcinoma: Methods and Protocols (Methods in Molecular Medicine) by Nagy A. Habib (Editor) Imperial College, London, UK. Outlines research methods applied in laboratories and clinics. Discusses advances in molecular characterization, novel gene isolation, and gene therapy. For basic and clinical researchers and clinicians. Expanded-outline format. DNLM: Carcinoma, Hepatocellular--etiology. |
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Hepatocellular Carcinoma (An Atlas of Its Pathology) by M. Kojiro Nakashima (Author) |
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