 |
|
MicroRNA in human saliva may help diagnose oral cancer
August 26, 2009PHILADELPHIA - Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.
"It is a Holy Grail of cancer detection to be able to measure the presence of a cancer without a biopsy, so it is very appealing to think that we could detect a cancer-specific marker in a patient's saliva," said Jennifer Grandis, M.D., professor of otolaryngology and pharmacology at the University of Pittsburgh School of Medicine and Cancer Institute and a senior editor of Clinical Cancer Research.
MicroRNAs are molecules produced in cells that have the ability to simultaneously control activity and assess the behavior of multiple genes. They are a thriving research topic right now, and researchers believe they could hold the key to early detection of cancer. The emergence of a microRNA profile in saliva represents a major step forward in the early detection of oral cancer.
"The oral cavity is a mirror to systemic health, and many diseases that develop in other parts of the body have an oral manifestation," said David T. Wong, D.M.D., D.M.Sc., Felix and Mildred Yip Endowed Professor at the University of California, Los Angeles School of Dentistry.
Wong and colleagues measured microRNA levels in the saliva of 50 patients with oral squamous cell carcinoma and 50 healthy control patients. They detected approximately 50 microRNAs.
Two specific microRNAs, miR-125a and miR-200a, were present at significantly lower levels in patients with oral cancer than in the healthier controls.
Wong said that the findings of this study would have to be confirmed by a larger and longer analysis.
American Association for Cancer Research
"The oral cavity is a mirror to systemic health, and many diseases that develop in other parts of the body have an oral manifestation," said David T. Wong, D.M.D., D.M.Sc., Felix and Mildred Yip Endowed Professor at the University of California, Los Angeles School of Dentistry.
Wong and colleagues measured microRNA levels in the saliva of 50 patients with oral squamous cell carcinoma and 50 healthy control patients. They detected approximately 50 microRNAs.
Two specific microRNAs, miR-125a and miR-200a, were present at significantly lower levels in patients with oral cancer than in the healthier controls.
Wong said that the findings of this study would have to be confirmed by a larger and longer analysis.
American Association for Cancer Research
Oral Cancer Current Events and Oral Cancer News RSSDoes green tea prevent cancer? Evidence continues to brew, but questions remain
Although scientists are reluctant to officially endorse green tea as a cancer prevention method, evidence continues to grow about its protective effects, including results of a new study published in Cancer Prevention Research, a journal of the American Association for Cancer Research, which suggests some reduction in oral cancer.
Green tea shows promise as chemoprevention agent for oral cancer, M. D. Anderson study finds
Green tea extract has shown promise as cancer prevention agent for oral cancer in patients with a pre-malignant condition known as oral leukoplakia, according to researchers at The University of Texas M. D. Anderson Cancer Center.
Dental researchers confirm microRNAs as biomarkers for oral cancer detection
A new study published by researchers at the UCLA School of Dentistry substantiates the effectiveness of measuring the microRNAs present in saliva to detect oral squamous cell carcinoma.
Smokeless tobacco safer than smoking
Smokeless tobacco products, as used in Europe and North America, do not appear to increase cancer risk.
Compliance and cost: Bitter pills to swallow in the age of oral chemotherapy
Though the growing shift toward oral chemotherapy agents offers cancer patients greater freedom and independence during their treatment, physicians say use of the new medications also poses more chances for patients to skip doses, miss prescription refills, and take their drugs in a dangerous way.
Research yields potential target for cancer, wound healing and fibrosis
Research conducted by Allison Berrier, PhD, Assistant Professor of Oral and Craniofacial Biology at the LSU Health Sciences Center New Orleans School of Dentistry, and colleagues, provides insights that may help scientists design novel approaches to control wound healing and fight diseases such as cancer and fibrosis.
Human Papillomavirus (HPV) Lesion Identified at the Dentist
Human papillomavirus (HPV) is a group of viruses that includes more than 100 different strains or types and is the most common sexually transmitted virus.
LSUHSC public health contributes to estimate of HPV-related cancers
Professor Vivien Chen, PhD,. Associate Professor Xiao Cheng Wu, MD, PhD and Assistant Professor Edward Peters, DMD, SM, ScD, at LSU Health Sciences Center New Orleans School of Public Health contributed five papers to the largest most comprehensive assessment of the burden of human papillomavirus (HPV)-associated cancers in the United States to date.
Saliva proteins could help detection of oral cancer
Clinicians could detect oral squamous cell carcinoma, a form of oral cancer, using a simple test that detects proteins in saliva, according to a report in the October 1, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.
Blue light used to harden tooth fillings stunts tumor growth
A blue curing light used to harden dental fillings also may stunt tumor growth, Medical College of Georgia researchers say.
More Oral Cancer Current Events and Oral Cancer News Articles
 |
Oral Cancer (American Cancer Society Atlas of Clinical Oncology) by Sol Silverman Jr. (Author) This new edition of the definitive Oral Cancer, provides a multidisciplinary approach to oral cancer prevention, diagnosis, treatment, and rehabilitation. The effective combination of both authoritative text and colored atlas has produced a thorough examination into this complex disease. Updates include (1) epidemiology, demographics and trends, (2) maxillofacial prosthetics, newer materials and advances in implants, and (3) managing complications in therapy. Expansions in this Fifth Edition comprise (1) new data on viral etiology, genetics and cell markers of oral cancer, and premalignant lesions, (2) diagnosis, staging, imaging, and nutrition, (3) genomics and molecular progression, (4) control of malignant lesions with newer data on agents, mechanisms, and the effectiveness of... |
 |
Meeting the Challenges of Oral and Head and Neck Cancer: A Survivor's Guide by Nancy E. Leupold (Author), James J. Sciubba (Author), Nancy E. Leupold (Editor), James J. Sciubba (Editor) Nancy Leupold, herself a survivor, and president and founder of Support for People with Oral and Head and Neck Cancer (SPOHNC), and James J. Sciubba present an overview of the different disciplines involved in the treatment of oral and head and neck cancer, with emphasis on providing information and survivor tips to help survivors cope with the disease, its treatment, and their consequential side effects. This book takes a deliberately different stance and approach from other survivor guides, in that it concentrates on helping the individual who has completed treatment and is now on the road to recovery. Furthermore, it is unique in that it is attempting to meet the challenges of oral and head and neck cancer with specific information, in the form of lists and tables of products and... |
 |
Oral Cancer: Diagnosis, Management, and Rehabilitation by J. W. Werning (Editor) Oral Cancer: Diagnosis, Management, and Rehabilitation provides readers with a systematic review of the diagnostic and treatment principles that maximize the outcomes of patients who have been diagnosed with oral cancer. Written by authorities in the fields of head and neck surgical oncology, radiation oncology, reconstructive surgery, dentistry, and oral and maxillofacial surgery, this textbook provides clinicians with a unified management philosophy that is firmly based upon the best available evidence in the peer-reviewed literature. In-depth clinical reviews of preferred treatment approaches and reconstructive techniques for each oral mucosal site facilitate the development of effective treatment strategies that are tailored to the location and extent... |
 |
Beating Oral Cavity Cancer Together Long Sleeve T-shirt Large White by Shop Zeus |
 |
Fight Against Oral Cancer Keychain by Design a Product LLC Text on keychain: Fight Against Oral Cancer * Durable acrylic key chain is crystal-clear and double-sided so the artwork or message is seen twice. * Sturdy metal ring holds your keys securely. * Full color printed images or messages are included. * If you have new ideas or need help selecting text for your custom keychains please contact us. * Size: 2 1/8" x 3 1/2" (Approx. business card) |
 |
Cankermelts Time-Release Medicated Discs, 36-Count Boxes (Pack of 2) by ORAHEALTH Only Cankermelts Natural-GX relieves pain and heals sores.Cankermelts Natural-GX is the only available product that relieves the pain of canker sores and sores from braces in minutes and will heal most sores within 1-5 days. Cankermelts Natural-GX is a to |
|
Oral Cancer Awareness Ribbon Mouse Pad by MyHeritageWear.com | |
![Oral Decline 7" [Explicit]](http://ecx.images-amazon.com/images/I/5168uenM6EL._SL160_.jpg) |
Oral Decline 7" [Explicit] Tooth and the Enamels (Primary Contributor) |
 |
Oral Cancer b |
 |
Beating Lip and Oral Cavity Cancer Together Sweatshirt Large White by Shop Zeus |
| © 2009 BrightSurf.com |