 |
|
A potential therapeutic agent for hepatic fibrosis
August 26, 2009Accumulating evidence suggests that connective tissue growth factor (CCN2) plays a central role in fibrotic conditions in many organ systems. Fibrosis is a scarring condition that is characterized by excessive collagen production that impedes normal cell function and can cause organ dysfunction and failure. A hallmark of fibrosing injury in the liver is the activation of hepatic stellate cells (HSCs) which become highly proliferative, synthesize increased levels of transforming growth factor (TGF)-β and CCN2, and produce excessive amounts of collagen. Previous studies have not investigated the effect of CCN2 antagonism in HSCs of human origin.
A research team led by Dr. David Brigstock addresses this question. Their work will be published on August 14, 2009 in World Journal of Gastroenterology.
By designing a novel antisense inhibitor that blocked CCN2 mRNA transcription and protein production, the investigators showed that in activated human HSCs, basal or TGF-β1-induced transcription and production of collagen I could be reduced, and the ability of the cells to actively divide was curtailed. The innovative features of this study involve the use of human HSCs and the delivery of the antisense molecule in the form of a hammerhead ribozyme, which has a more efficient blocking action than some other conventional antisense methods. The data show that the anti-fibrotic properties of CCN2 hammerhead ribozyme are to the result of a reduction of collagen production and cell proliferation.
The results suggest that CCN2 hammerhead ribozyme has utility as a therapeutic agent for treating hepatic fibrosis in vitro. This is important as therapy for liver fibrosis is currently lacking despite the fact that millions of individuals around the world suffer from liver fibrosis caused by hepatitis, alcohol consumption, and other types of chronic liver injury.
World Journal of Gastroenterology
The results suggest that CCN2 hammerhead ribozyme has utility as a therapeutic agent for treating hepatic fibrosis in vitro. This is important as therapy for liver fibrosis is currently lacking despite the fact that millions of individuals around the world suffer from liver fibrosis caused by hepatitis, alcohol consumption, and other types of chronic liver injury.
World Journal of Gastroenterology
Hepatic Fibrosis Current Events and Hepatic Fibrosis News RSSAntifibrotic effects of green tea
Several studies have shown that lipid peroxidation stimulates collagen production in fibroblasts and hepatic stellate cells (HSC), and plays an important role in the development of liver fibrosis.
Is 31P MRS a useful tool for evaluating early acute hepatic radiation injury?
Acute hepatic radiation injury could lead to necrosis of hepatocytes, fatty degeneration and hepatic fibrosis. At the present, the gold standard test is liver biopsy.
Melatonin may be served as a potential anti-fibrotic drug
In China, the incidence of liver cirrhosis is still high. Liver cirrhosis results from fibrosis. If treated properly at fibrosis stage, cirrhosis can be prevented.
Mayo Clinic's new imaging technology accurately identifies a broad spectrum of liver disease
A new study shows that an imaging technology developed by Mayo Clinic researchers can identify liver fibrosis with high accuracy and help eliminate the need for liver biopsies. Liver fibrosis is a common condition that can lead to incurable cirrhosis if not treated in time.
An effective strategy for inhibition of cirrhosis
In China, the incidence of liver cirrhosis is still high, although new therapeutic approaches have recently been proposed, there is no established therapy for liver fibrosis, and Authors investigated the prevention effects of Chinese Medicine Qianggan-Rongxian Soup on liver fibrosis induced by DMN in rat.
Liver fibrosis will be treated by a potential target
The outcome of hepatitis is either self recovery or its development into liver fibrosis or, further, liver cirrhosis. Liver fibrosis is the early pathological process of cirrhosis, which is considered a reversible, wound-healing response. Since no ideal drug is available for its therapy, liver fibrosis is currently considered to be a major worldwide health problem.
Study details hepatitis C ability to block immune system response
Hepatitis C virus (HCV) is a worldwide public health problem. The World Health Organization estimates that 170 million people worldwide are chronically infected and that between 3-4 million are newly infected annually.
More Hepatic Fibrosis Current Events and Hepatic Fibrosis News Articles
|
Pathobiology Hepatic Fibrosis: (International Congress Series) by Hirayama (Author), Chisato Hirayama (Other Contributor) | |
 |
Congenital Hepatic Fibrosis Awareness Ribbon Mouse Pad by MyHeritageWear.com The Congenital Hepatic Fibrosis Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Congenital Hepatic Fibrosis Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Congenital Hepatic Fibrosis Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
 |
Hepatic Fibrosis by Ming-Liang, M.D. Cheng (Editor), Chang-qing, M.D., Ph.D. Yang (Editor) This book has contributions by 16 Chinese hepatologists, highlighting important advances in worldwide hepatic fibrosis research in recent years, and covers the pathogenesis of hepatic fibrosis, etiology, pathology, molecular biology, biomarkers, clinical features, diagnosis, pharmacology, as well as treatment and prevention of hepatic fibrosis, including the use of integrative traditional Chinese medicine and western medicine therapies. The contents are comprehensive, novel, and provide a complete understanding of hepatic fibrosis. This book provides a guide for clinical workers to prevent and treat hepatic fibrosis and cirrhosis, especially at the early stage of the diseases. This is a valuable handbook for physicians and basic researchers. |
 |
Hepatic Fibrosis: Pathogenesis, Diagnosis and Emerging Therapies, An Issue of Clinics in Liver Disease (The Clinics: Internal Medicine) by Scott Friedman (Author) Hepatic fibrosis is the final common pathway for a multitude of liver injuries. Viral-, immune-, or toxin-mediated liver injuries all result in expansion of the extracellular matrix with distortion of hepatic architecture and development of cirrhosis. Originally thought of as a one-way street, hepatic fibrosis now is recognized as a dynamic process with the potential for significant resolution. Authors in this issue address the genetic determinants of fibrosis, oxidant stress, cellular contractility and vasoregulation, as well as relationships between stellate cell activation, progenitor cells and hepatic regeneration. Current and future antifibrotic therapies are also discussed. |
|
Blood test could replace liver biopsy for MTX users: hepatic fibrosis unlikely with normal result. (PIIINP).(methotrexate): An article from: Skin & Allergy News by Kathryn Demott (Author) This digital document is an article from Skin & Allergy News, published by International Medical News Group on August 1, 2002. The length of the article is 572 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Blood test could replace liver biopsy for MTX users: hepatic fibrosis unlikely with normal result. (PIIINP).(methotrexate) Author: Kathryn Demott Publication: Skin & Allergy News (Magazine/Journal) Date: August 1, 2002 Publisher: International Medical News Group Volume: 33 Issue: 8 Page: 1(2) Distributed by Thomson... | |
|
Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats.: An article from: Phytomedicine: International ... Journal of Phytotherapy & Phytopharmacology by C.C. Shih (Author), Y.W. Wu (Author), W.C. Lin (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on June 1, 2005. The length of the article is 5982 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats. Author: C.C. Shih Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) Date: June 1, 2005 Publisher: Thomson Gale Volume: 12 Issue: 6-7 Page:... | |
![Ethyl caffeoate: Liquid chromatography-tandem mass spectrometric analysis in Verdicchio wine and effects on hepatic stellate cells and intracellular peroxidation ... [An article from: Analytica Chimica Acta]](http://ecx.images-amazon.com/images/I/415FBN4EPVL._SL160_.jpg) |
Ethyl caffeoate: Liquid chromatography-tandem mass spectrometric analysis in Verdicchio wine and effects on hepatic stellate cells and intracellular peroxidation ... [An article from: Analytica Chimica Acta] by N.G. Frega (Author), E. Boselli (Author), E. Bendia (Author), M. Minardi (Author), Ben (Author) This digital document is a journal article from Analytica Chimica Acta, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: Analysis of Verdicchio (a white wine produced in Italy) with high performance liquid chromatography-tandem mass spectrometry (HPLC-ESI-MS-MS) showed a concentration of ethyl caffeoate (CfE), a natural phenolic substance, of 67.3@mmolL^-^1; CfE was then purified from wine with preparative reversed phase HPLC and tested on rat hepatic stellate cell cultures (HSC). HSC proliferation induced by iron(III) nitrilotriacetate (FeNTA), a pro-oxidant agent (absorbance=0.68+/-0.03 versus 0.32+/-0.02 in controls), was... |
 |
Liver Cirrhosis by K. Okita (Editor) Yamaguchi Univ., Yamaguchi, Japan. Proceedings of the 1999 Yamaguchi Symposium on Liver Diseases, useful for physicians and hepatologists interested in hepatic fibrogenesis and hepatocarcinogenesis. Novel approaches for treatment of hepatic disease, including gene therapy. |
|
Hepatic fibrosis. by Ed. by Ming-Liang Cheng and Chang-qing Yang. (Author) | |
|
Bilharzial hepatic fibrosis in Iraq, by Ahmed H Shamma (Author) |
| © 2009 BrightSurf.com |