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Dental researchers confirm microRNAs as biomarkers for oral cancer detection
August 26, 2009FINDINGS:
A new study published by researchers at the UCLA School of Dentistry substantiates the effectiveness of measuring the microRNAs present in saliva to detect oral squamous cell carcinoma. Like hall monitors in an elementary school, microRNAs are the molecules produced by cells that simultaneously asses the behavior of multiple genes and control their activity.
Dr. David Wong, UCLA's Felix and Mildred Yip Professor of Dentistry, and his colleagues previously demonstrated the usefulness of proteome and transcriptome diagnostics for oral cancer; this new research expands the "diagnostic alphabet" of genetic salivary biomarkers that can yield a diagnosis on the molecular level long before a tumor is present. The scientists' latest results show that while the saliva of healthy individuals contains about 50 microRNAs, two in particular - miR-125a and miR-200a - are present at significantly different levels in the saliva of individuals suffering from oral squamous cell carcinoma.
IMPACT:
Oral squamous cell carcinoma accounts for more than 90 percent of oral cancers worldwide and is the sixth most common cancer in the United States. It is particularly lethal, with a five-year survival rate post-diagnosis that hovers below 50 percent and has not improved in three decades. Enhancements in the area of early diagnosis, therefore, are key to making strides against the disease. This latest research offers another minimally invasive, cost-effective method for early detection of the disease that can be translated to earlier treatment and potential improvement in long-term survival rates.
University of California - Los Angeles
IMPACT:
Oral squamous cell carcinoma accounts for more than 90 percent of oral cancers worldwide and is the sixth most common cancer in the United States. It is particularly lethal, with a five-year survival rate post-diagnosis that hovers below 50 percent and has not improved in three decades. Enhancements in the area of early diagnosis, therefore, are key to making strides against the disease. This latest research offers another minimally invasive, cost-effective method for early detection of the disease that can be translated to earlier treatment and potential improvement in long-term survival rates.
University of California - Los Angeles
Squamous Cell Carcinoma Current Events and Squamous Cell Carcinoma News RSSSwitching immunosuppressants reduces cancer risk in kidney
Switching to a newer type of immunosuppressant drug may reduce the high rate of skin cancer after kidney transplantation, according to research being presented at the American Society of Nephrology's 42nd Annual Meeting and Scientific Exposition in San Diego, CA.
Curcumin may inhibit nicotine-induced activation of head and neck cancers
Curcumin, the compound that gives curry powder its yellow/orange color, may inhibit the adverse effects of nicotine in patients with head and neck cancer who continue to smoke.
Short-term stress enhances anti-tumor activity in mice, Stanford study shows
Public speaking, anyone? Or maybe a big job interview? Dry your palms and take a deep, calming breath; there may be a silver lining.
Prevent periodontitis to reduce the risk of head and neck cancer
Chronic periodontitis, a form of gum disease, is an independent risk factor for head and neck squamous cell carcinoma. This suggests the need for increased efforts to prevent and treat periodontitis as a possible means to reduce the risk of this form of cancer.
MicroRNA in human saliva may help diagnose oral cancer
Researchers continue to add to the diagnostic alphabet of saliva by identifying the presence of at least 50 microRNAs that could aid in the detection of oral cancer, according to a report in Clinical Cancer Research, a journal of the American Association for Cancer Research.
Study Links Virus To Some Cases Of Common Skin Cancer
A virus discovered last year in a rare form of skin cancer has also been found in people with the second most common form of skin cancer among Americans, according to researchers at the Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute.
Laser microsurgery for tongue cancer is as effective as invasive open surgery according to new study
Transoral (through-the-mouth) laser surgery to remove cancer at the base of the tongue is as effective as more invasive open surgery and may improve quality of life according to a new study by Rush University Medical Center.
Skin Lesion Leads To More Cancer Types Than Once Believed
Dermatologist Martin Weinstock has found that sun-damaged rough patches on the skin known as actinic keratoses lead to more forms of skin cancer than previously thought.
Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals
Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on nucleocytoplasmic translocation and reliant on the integrity of nuclear localization signals in the OGF receptor (OGFr).
Drinking very hot tea can increase the risk of throat cancer
People are advised to wait a few minutes before drinking a cup of freshly-boiled tea today as a new study, published on bmj.com, finds that drinking very hot tea (70°C or more) can increase the risk of cancer of the oesophagus, the muscular tube that carries food from the throat to the stomach.
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