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PPAR-g agonists have potential therapeutic role in gastric carcinoma?
August 27, 2009Recently, the potential of PPAR-γ as a target for the prevention and treatment of cancer has been widely studied. However, the potential therapeutic role of PPAR-γ agonists has been questioned, based on contradictory results. Studies using animal models of colon cancer found that PPAR-γ agonists increased the development of colon tumors. This contradictory result was supplemented by a recent report using transgenic mice expressing a constitutive active form of PPAR-γ in mammary glands which showed that PPAR-γ signaling accelerated tumor development in mammary glands. The actual role of PPAR-γ in cancer has been complicated by recent findings that PPAR-γ agonists affect cancer cells independently of PPAR-γ, and silencing of PPAR-γ and a PPAR-γ antagonist inhibit cancer cell growth. To date, the role of PPAR-γ in gastric carcinogenesis remains unclear.
A research article to be published on August 21, 2009 in the World Journal of Gastroenterology addresses this question. A study from China found that PPAR-γ may be involved in gastric carcinogenesis, and that the PPAR-γ agonist 15d-PGJ2 may inhibit the growth of human gastric carcinoma MGC803 cell by inducing apoptosis and G1/G0 arrest, involving survivin, Skp2 and p27, but via a PPAR-γ-independent pathway.
The study showed that the PPAR-γ agonist 15d-PGJ2 inhibited growth of cultured gastric cancer MGC803 cells, and demonstrated that the PPAR-γ antagonist GW9662 did not block this effect of 15d-PGJ2 and that 2.5 μM GW9662 inhibited growth of MGC803 cells. Furthermore, PPAR-γ siRNA remarkably inhibited the growth of MGC803 cells.
These results indicated that 15d-PGJ2 inhibited growth of cultured gastric carcinoma MGC803 cells by a PPAR-γ-independent pathway. These results also suggest that PPAR-γ agonists could be useful in the chemoprevention or chemotherapy of gastric malignancies.
World Journal of Gastroenterology
These results indicated that 15d-PGJ2 inhibited growth of cultured gastric carcinoma MGC803 cells by a PPAR-γ-independent pathway. These results also suggest that PPAR-γ agonists could be useful in the chemoprevention or chemotherapy of gastric malignancies.
World Journal of Gastroenterology
Gastric Carcinoma Current Events and Gastric Carcinoma News RSSYes-associated protein: Early diagnosis of gastric carcinoma
Yes-associated protein (YAP) is a type of cellular adaptor protein and transcriptional co-activator.
Candidate markers for gastric cancer
The sequencing of the human genome has opened the door for proteomics by providing a sequence-based framework for mining proteomes.
A new insight on ethanol-induced gastric mucosa injury
Many people all over the world indulge themselves in drinking, which is correlated to a wide spectrum of medical, psychological, behavioral, and social problems.
U of T researchers reveal Epstein-Barr virus protein contributes to cancer
Researchers at the University of Toronto have discovered that the EBNA1 protein of Epstein-Barr virus (EBV) disrupts structures in the nucleus of nasopharyngeal carcinoma (NPC) cells, thereby interfering with cellular processes that normally prevent cancer development.
A potential route for human tumor gene therapy
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value.
Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
This study determined the efficiency of a gastric juice PCR test for the detection of H. pylori infection in patients receiving PPI therapy and compared it with histology and gastric biopsy PCR.
How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?
The Gram negative bacterium H pylori is involved in the pathogenesis of several gastrointestinal diseases, ultimately leading to gastric carcinoma. Adhesion of the bacteria to the gastric mucosa is an essential step for colonization and infection.
A new prognostic tool for gastric carcinomas? (and maybe other cancers)
A new way to identify gastric carcinoma patients with high probability of develop a more aggressive form of disease has just been described on the June issue of the journal Glycobiology.
Helicobacter pylori Acquisition Most Common In Young Children (P931)
A US study in this week's issue of THE LANCET highlights how most newly acquired infections of the intestinal bacterium Helicobacter pylori probably occur in children younger than 10 years of age. The authors of the study suggest that treatment and prevention strategies should therefore be targeted at young children. H pylori infection is associated with many gastro-intestinal disorders including gastritis, gastric ulcer, duodenal ulcer, gastric carcinoma, and primary gastric -cell lymphoma. H pylori is common worldwide, but the age at which it is acquired is unclear. Hoda Malaty and colleagues from Baylor College of Medicine, Houston, USA, studied 224 children (99 black, 125 white
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