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Antimicrobial antibodies in celiac disease: Trick or treat?
August 27, 2009Anti-microbial antibody formation has been reported in celiac disease. Relatively high positivity rates were observed for the conventional antibodies, for example, ASCA, anti-OmpW, and anti-I2, and they were known to decrease after a successful gluten free-diet. The importance of newly discovered inflammatory bowel disease-associated antibodies (including anti-glycan antibodies and anti-OMP) in celiac disease is not sure. The presence of anti-microbial antibodies in relation to clinical presentation of the disease and NOD2/CARD15 mutations was also not investigated.
A research article to be published on August 21, 2009 in the World Journal of Gastroenterology addresses this question. Hungarian researchers from the University of Debrecen in Debrecen and the Semmelweis University in Budapest have shown in a well-characterized CD cohort that the anti-glycan antibody positivity is a common feature of celiac disease at the time of diagnosis and is lost after long-term gluten-free diet. The positivity rate and titers at diagnosis are as high as observed in Crohn's disease. The presence of anti-glycan antibodies is associated with the presenting symptoms, especially with severe malabsorption but not with mutations in NOD2/CARD15. No higher prevalence of anti-microbial antibodies is observed in the unaffected, first-degree relatives of this patient cohort.
World Journal of Gastroenterology
Celiac Disease Current Events and Celiac Disease News RSSIrritable Bowel Syndrome patients not at more risk of colon cancer, polyps
Patients with irritable bowel syndrome are at no greater risk of having polyps, colon cancer or inflammatory bowel diseases than healthy people undergoing colonoscopies, according to new research published in the American Journal of Gastroenterology.
Gastroenterologists Study Mind/Body Techniques for Treating Celiac Disease
For adults and children diagnosed with celiac disease, the only treatment is a gluten-free diet, which can be very challenging. Gastroenterologists at Rush University Medical Center are conducting a new study to see if mind/body techniques could help patients with celiac disease adhere to the very strict diet.
UM scientists pinpoint critical molecule to celiac disease, possibly other autoimmune disorders
It was nine years ago that University of Maryland School of Medicine researchers discovered that a mysterious human protein called zonulin played a critical role in celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes.
ADA publishes practice guidelines for nutrition care for patients with spinal cord injury
The American Dietetic Association has published new evidence-based nutrition practice guidelines for registered dietitians on nutrition care for patients with spinal cord injury.
Pinpointing cause of colic: UT Houston research identifies organism that could trigger constant crying
Researchers at The University of Texas Health Science Center at Houston say one organism discovered during their study may unlock the key to what causes colic, inconsolable crying in an otherwise healthy baby.
Children's Hospital Oakland scientist characterizes new syndrome of allergy, apraxia, malabsorption
A landmark study conducted by Children's Hospital & Research Center Oakland is the first to reveal a new syndrome in children that presents with a combination of allergy, apraxia and malabsorption. Autism spectrum disorders were variably present.
Mayo Clinic study finds celiac disease 4 times more common than in 1950s
Celiac disease, an immune system reaction to gluten in the diet, is over four times more common today than it was 50 years ago, according to findings of a Mayo Clinic study published this month in the journal Gastroenterology.
How to confirm the causes of iron deficiency anemia in young women
Iron-deficiency anaemia (IDA) is commonly seen in women aged <50 years. The diagnostic workflow in young women affected by IDA is not clearly established.
UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
UCLA scientists have linked for the first time intestinal inflammation with systemic chromosome damage in mice, a finding that may lead to the early identification and treatment of human inflammatory disorders.
Immune genes adapt to parasites
Thank parasites for making some of our immune proteins into the inflammatory defenders they are today.
More Celiac Disease Current Events and Celiac Disease News Articles
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The First Year: Celiac Disease and Living Gluten-Free: An Essential Guide for the Newly Diagnosed by Jules E. Dowler Shepard (Author) If you’ve just been diagnosed with celiac disease, you’re not alone: as many as 1 in 133 Americans have this autoimmune disorder characterized by an inability to digest gluten, a protein found in wheat and other grains. For ten years, Jules Shepard’s gastrointestinal symptoms went misdiagnosed. Finally diagnosed, she experienced a rollercoaster of emotions and illness the year following, as she discovered what she could and could not eat through trial and error. Now, in The First Year®: Celiac Disease and Living Gluten-Free, Shepard explains everything you need to learn and do upon your or a family member’s diagnosis.
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Celiac Disease (Revised and Updated Edition): A Hidden Epidemic by Peter H.r. Green (Author), Rory Jones (Author) Unmasking One of the Most Underdiagnosed Autoimmune Diseases Do you suffer from gastrointestinal complaints, fatigue, headaches, joint pain, anemia, and/or itchy skin conditions? Have you consulted numerous doctors, and been prescribed drugs and diets that have only temporarily alleviated some symptoms? If so, you may have celiac disease, a hereditary autoimmune condition that affects nearly one in every hundred people—97 percent of whom remain undiagnosed and untreated. If you are one of these people, the real answer to your medical problems may lie in this book. Dr. Peter Green, director of the Celiac Disease Center at Columbia University and internationally renowned expert on the disease, together with Rory Jones, an accomplished science writer who was diagnosed... |
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The G-Free Diet: A Gluten-Free Survival Guide by Elisabeth Hasselbeck (Author), Peter Green (Foreword) For years, Elisabeth Hasselbeck couldn't figure out what was making her sick. She asked doctors and consulted nutritionists, but no one seemed to have any answers. It wasn't until spending time in the Australian Outback, living off the land on the grueling Survivor TV show, that, ironically, her symptoms vanished. Returning home, she pinpointed the food that made her sick -- gluten, the binding element in wheat. By simply eliminating it from her diet, she was able to enjoy a completely normal, healthy life. But that wasn't all. Hasselbeck discovered the myriad benefits that anyone can enjoy from a gluten-free diet: from weight loss and increased energy to even the alleviation of the conditions of autism. In this all-inclusive book, Hasselbeck shares her hard-earned wisdom on... |
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Tell Me What to Eat If I Have Celiac Disease: Nutrition You Can Live With by Kimberly A. Tessmer (Author) "This comprehensive resource describes every aspect of celiac disease, including diagnosis and daily survival skills. There is an entire chapter which contains invaluable advice from those with the most experience--people with celiac disease!" --Trisha B. Lyons, RD, LD, MetroHealth Medical Center, Cleveland, Ohio --Kenneth Fine, MD, director of operations and director of medical research, Intestinal Health Institute |
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Kids with Celiac Disease : A Family Guide to Raising Happy, Healthy, Gluten-Free Children by Danna Korn (Author) This is the first practical guide for the families of children and teenagers with celiac disease, a chronic, life-long digestive disorder. One out of 250 Americans is born with this genetic autoimmune condition, which is characterized by intolerance of gluten (wheat, rye, barley, malt, and other food additives) and often goes undiagnosed. In a supportive conversational style, Danna Korn shows that it's possible for kids with celiac disease and their families to lead happy and healthy lives. Parents find advice on how to deal with the diagnosis, cope with emotional turmoil, and help their child develop a positive and constructive attitude. Especially important is the guidance on menu planning, grocery shopping, strategies for proper food preparation, and deciding whether or not... |
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Celiac Disease: A Guide to Living with Gluten Intolerance by RN Sylvia Llewelyn Bower (Author), M.S. Mary Kay Sharrett (Contributor), Steve Plogsted (Contributor) Celiac disease is a digestive disorder caused by a sensitivity to the protein gluten in wheat flour, which in turn can damage the small intestine and inhibit the body’s absorption of nutrients from food. The disease is hereditary and can affect entire families. Cowritten by a registered nurse who lives with celiac disease, a dietician, and a clinical pharmacist, this indispensable guide tackles all aspects of the disease, including symptoms, diagnosis, management, complications, and current research. While many cookbooks and dietary manuals on gluten intolerance exist, Celiac Disease is the only book on how to live fully and richly while maintaining a gluten-free lifestyle. In addition to learning how to set up and maintain a gluten-free kitchen, readers find strategies for tackling... |
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Healthier Without Wheat: A New Understanding of Wheat Allergies, Celiac Disease, and Non-Celiac Gluten Intolerance. by Stephen Wangen (Author) This is the leading resource for discovering your wheat allergy or gluten intolerance. For millions of people, bread, pasta, and many other foods are bad for their health. Thousands of people have already come to their own realization that they are healthier without wheat in their diet, but it can be difficult to figure out when most doctors aren t knowledgeable on the topic. This book provides validation for what these people have discovered, and explains how you too can determine whether or not wheat and gluten are making you sick. In Healthier Without Wheat you learn the difference between celiac disease, non-celiac gluten intolerance, and wheat allergies. You will discover how hundreds of health problems are connected to wheat and gluten reactions and why sorting this out on your... |
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Recognizing Celiac Disease: Signs, Symptoms, Associated Disorders & Complications by Cleo J. Libonati (Author), John M. Libonati II (Editor), David M. Capuzzi (Editor) "Recognizing Celiac Disease should be on the shelf of every family affected by celiac disease as well as the health professionals caring for them." - Gastroenterology Nursing Magazine, September/October 2007. Whether you are a healthcare professional or have celiac disease yourself, this is a valuable reference you will use again and again. - Explains GLUTEN, GLUTEN sources in food, how GLUTEN triggers harmful reactions in your body and the difference between CELIAC DISEASE and GLUTEN SENSITIVITY. |
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The GF Kid: A Celiac Disease Survival Guide by Melissa London (Author), Eric Glickman (Illustrator) Book Description "I'm no different than any other kid. I m just a GF kid";, says Paris, matter-of-factly. She is the spunky eleven-year-old narrator of this story for kids with celiac disease who must eat gluten-free (GF) foods. With equal parts humor and directness, Paris* gets right down to business explaining what it is like to have celiac disease. (*Paris's mom wrote the story, full of her daughter's wisecracking comments, and her dad drew the funny, cartoony illustrations.) Celiac disease is an autoimmune disorder that affects 1 in 133 kids. If you have celiac disease, you cannot tolerate gluten, a substance found in many foods, including--gulp!--cake, cookies, pasta, or pizza. Don't sweat it. Paris has creative GF solutions for you. She offers tips on what to bring... |
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The Essential Gluten-Free Grocery Guide by Triumph Dining Gluten Free (Author) We've invested thousands of hours in research - contacting thousands of food manufacturers, editing, and fact checking - to bring you the most thorough and useful gluten free grocery guide available. The updated and revised 2nd edition of The Essential Gluten-Free Grocery Guide includes 30,000+ gluten free foods, featuring 20% more products than competing gluten free guides. Yet, at only 6 x 9 inches, it's small enough to fit in your purse, but big enough so that you can read it easily. The guide's full-color navigation system makes finding your favorite gluten free products a snap. This gluten free grocery guide covers both prominent name-brand products (like Kraft, Heinz and Frito-Lay) and local supermarket brands in every region of the U.S. Triumph Dining is America's leading gluten... |
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