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Toward a nanomedicine for brain cancer
September 10, 2009In an advance toward better treatments for the most serious form of brain cancer, scientists in Illinois are reporting development of the first nanoparticles that seek out and destroy brain cancer cells without damaging nearby healthy cells. The study is scheduled for the Sept. 9 issue of ACS' Nano Letters, a monthly journal.
Elena Rozhkova and colleagues note the pressing need for new ways to treat the disease, glioblastoma multiforme (GBM), which often causes death within months of diagnosis. Recent studies show that titanium dioxide nanoparticles, a type of light-sensitive material widely used in sunscreens, cosmetics, and even wastewater treatment, can destroy some cancer cells when the chemical is exposed to ultraviolet light. However, scientists have had difficulty getting nanoparticles, each about 1/50,000th the width of a human hair, to target and enter cancer cells while avoiding healthy cells.
The scientists' solution involves chemically linked titanium dioxide nanoparticles to an antibody that recognizes and attaches to GMB cells. When they exposed cultured human GMB cells to these so-called "nanobio hybrids," the nanoparticles killed up to 80 percent of the brain cancer cells after 5 minutes of exposure to focused white light. The results suggest that these nanoparticles could become a promising part of brain cancer therapy, when used during surgery, the researchers say.
American Chemical Society
American Chemical Society
Brain Cancer Current Events and Brain Cancer News RSSMagnetic nanoparticles to simultaneously diagnose, monitor and treat
Whether it's magnetic nanoparticles (mNPs) giving an army of 'therapeutically armed' white blood cells direction to invade a deadly tumour's territory, or the use of mNPs to target specific nerve channels and induce nerve-led behaviour (such as the life-dependant thumping of our hearts), mNPs have come a long way in the past decade.
Angiochem crosses BBB, shows safety, efficacy in phase 1/2 brain cancer studies
Angiochem, Inc. a clinical-stage biotechnology company developing drugs that are uniquely capable of crossing the blood-brain barrier to treat brain diseases, announced today that its lead drug candidate, ANG1005, has demonstrated a favorable safety and efficacy profile in more than 100 patients with brain cancer from two separate Phase 1 /2 clinical studies in patients with progressive gliomas, including recurrent glioblastoma, and in patients with progressive brain metastases.
UM scientists pinpoint critical molecule to celiac disease, possibly other autoimmune disorders
It was nine years ago that University of Maryland School of Medicine researchers discovered that a mysterious human protein called zonulin played a critical role in celiac disease and other autoimmune disorders, such as multiple sclerosis and diabetes.
Experts warn over health check brain scans
A new study has voiced concern about the growing market for brain screening tests, which people can buy as part of a general health MOT.
Avastin dramatically improves response, survival in deadly recurrrent glioblastomas
The targeted therapy Avastin, alone and in combination with the chemotherapy drug CPT-11, significantly increased response rates, progression-free survival times and survival rates in patients with a deadly form of brain cancer that had recurred.
Computational Process Zeroes in on Top Genetic Cancer Suspects
Johns Hopkins engineers have devised innovative computer software that can sift through hundreds of genetic mutations and highlight the DNA changes that are most likely to promote cancer.
NIH study reveals new genetic culprit in deadly skin cancer
Drawing on the power of DNA sequencing, National Institutes of Health researchers have identified a new group of genetic mutations involved in the deadliest form of skin cancer, melanoma.
NIH researchers identify key factor that stimulates brain cancer cells to spread
Researchers funded by the National Institutes of Health have found that the activity of a protein in brain cells helps stimulate the spread of an aggressive brain cancer called glioblastoma multiforme (GBM).
Anti-psychotic drugs could help fight cancer
The observation that people taking medication for schizophrenia have lower cancer rates than other people has prompted new research revealing that anti-psychotic drugs could help treat some major cancers.
STAT3 Gene Regulates Cancer Stem Cells in Brain Cancer
In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation.
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Living with a Brain Tumor: Dr. Peter Black's Guide to Taking Control of Your Treatment by Peter Black (Author) Each year, 100,000 people in the United States are diagnosed with a brain tumor. With his new book, Dr. Peter Black fills a gap in the lay readership, providing an accessible medical resource for adult patients and their families. Dr. Black, who has operated on more than 3,000 patients with brain tumors, is uniquely qualified to discuss both clinical treatment of and research into brain tumors. This invaluable resource tells patients everything they need to know to understand and address their diagnosis, in a four-part structure: • “What is a Brain Tumor?" provides straightforward information about how brain tumors are diagnosed, the different types of tumors and how they develop, and where to go for treatment. • “Coping with Shock” addresses the emotional... |
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Silver Swarovski Crystals Ribbon Pin Brooch: Brain Cancer & Brain Disorder or Disability Awareness by PSDZ This Silver Ribbon Pin symbolizes the fight against: Brain Cancer & Brain Disorders or Disabilities. Dozens of sparkling, Swarovski Crystals have been hand set in this piece and skilled artisans have finished it in a glossy, Silver Enamel. A meaningful and beautiful brooch. Height: 1.75 Inch Width: .75 Inch Each of these items has been hand enameled by skilled artisans, and set with genuine, Swarovski Crystals. The pins frame is crafted from fine pewter. Our Collection adds the definitive touch to any gift-giving occasion. Also, this collection has been issued in limited editions and each piece will become a valuable keepsake to its owner, for years to come. Please see other items in this collection in our Amazon Store: PSDZ. Jewelry Boxes, Business Card Holders, Music... |
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Brain Cancer, Kids Light T-Shirt by CafePress |
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Curveball: When Life Throws You a Brain Tumor by Liz Holzemer (Author) Life seemed idyllic for thirty-two-year-old Liz Holzemer. Wife of Major League Baseball pitcher Mark Holzemer, Liz was enjoying a successful career as a journalist when an MRI revealed a baseball-size brain tumor she soon found out was called meningioma. Told with clarity and unwavering humor, this book is an inspirational and informative account of one woman’s battle for her life. It shows how she emerged from this frightening diagnosis and two brain surgeries retaining her remarkable spirit of survival and renewed sense of purpose and hope. With practical information about meningioma and brain surgery, Curveball is a manual for people who face life-altering challenges and is also proof that one need not fight such battles alone. |
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The NewsHour Reports on Brain Research, Treatment and Disease Starring: Betty Ann Bowser; Dr. Mickey Collins; Dr. Mark Lovell; Susan Dentzer; Dr. Michael Simberkoff; Paul Allen Also With: MacNeil / Lehrer Productions (Producer) The NewsHour reports on brain research and treatments for brain injury and disease. Included are segments featuring research on diagnosing and treating concussion; traumatic brain injury treatment of veterans; the development of a brain mapping tool; research on cell phone use and its effects on the brain and research that demonstrates the human body is able to produce new brain cells. This product is manufactured on demand using DVD-R recordable media. Amazon.com's standard return policy will apply. |
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Cancer Be Gone Guided imagery CD taps into the immense power of the mind to enhance comfort, healing, an optimistic attitude and positive expectations. Metaphor of "cancer as weeds in a garden that are easily managed". |
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Sterling Silver Gray Enamel Awareness Ribbon Charm, 7/8 inch, Diabetes, Brain Cancer by Silver Messages--Free US Shipping Sterling Silver Gray Enamel Awareness Ribbon Charm, 7/8 inch, Diabetes, Brain Cancer |
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Brain Cancer Awareness Ribbon Mouse Pad by MyHeritageWear.com The Brain Cancer Ribbon proudly displayed on a mouse pad. There is no better way to achieve awareness for the meaning of the Brain Cancer Ribbon than to display it on your mouse pad for everyone to see. The mouse pad measures at 9.25 x 7.75, it is machine washable, and the colors will not fade or run. Start gaining awareness today by presenting your Brain Cancer Ribbon mouse pad at work or at home. It is certain to keep your mouse rolling in style all while gaining support and awareness! |
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Brain Cancer, Infant/Toddler T-Shirt by CafePress |
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Hope Springs for Brain Cancer by Expressions from the Heart Designed with gift giving and memento keeping in mind, each mouth-blown, glass, heart-shaped ornament features a waffle-like texture into which 160 Swarovski crystals are set. The evocative line offers a fresh and very sentimental option for ornament lovers seeking an alternative to just another tree trimming collectible. Each spectacular piece is suspended from an elegant, bow-trimmed, ribbon and comes packaged, for giving and keeping, in a lovely, high-quality box. Each design has its own special name, accompanied by an evocative story, presented on a story card within the gift box. |
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