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Ketamine reduces suicidality in depressed patients
September 10, 2009Drug treatment options for depression can take weeks for the beneficial effects to emerge, which is clearly inadequate for those at immediate risk of suicide. However, intravenous (IV) ketamine, a drug previously used as an anesthetic, has shown rapid antidepressant effects in early trials.
Researchers have now explored ketamine's effects on suicidality in patients with treatment-resistant depression, and are publishing their results in the September 1st issue of Biological Psychiatry. Ketamine acutely reduced suicidal thoughts when patients were assessed 24 hours after a single infusion. This reduction in suicidality was maintained when patients received repeated doses over the next two weeks.
Corresponding author Rebecca Price commented on these encouraging findings: "If these findings hold up in larger samples of high-risk suicidal patients, IV ketamine could prove an attractive treatment option in situations where waiting for a conventional antidepressant treatment to take effect might endanger the patient's life."
Since this was a preliminary study in a small group of depressed patients, further research is needed to replicate these results. However, the findings are promising and could result in improved treatment for suicidal patients in the future.
Elsevier
Since this was a preliminary study in a small group of depressed patients, further research is needed to replicate these results. However, the findings are promising and could result in improved treatment for suicidal patients in the future.
Elsevier
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People are more suggestible under laughing gas
The pain-relieving effects of nitrous oxide - laughing gas - may be enhanced by suggestion or hypnosis, according to a new study by UCL (University College London). The study's findings - that people are more suggestible under the gas - mean that dental patients may benefit from being coached to relax while undergoing sedation.
Millisecond brain signals predict response to fast-acting antidepressant
Images of the brain's fastest signals reveal an electromagnetic marker that predicts a patient's response to a fast-acting antidepressant, researchers have discovered.
Researchers explore the antidepressant effects of ketamine
Drug treatments for depression can take many weeks for the beneficial effects to emerge. The excruciating and disabling nature of depression highlights the urgency of developing treatments that act more rapidly.
Study shows new strategy for developing antidepressants
Researchers may be able to develop an antidepressant which takes effect almost immediately by directly targeting novel molecules in the brain instead of taking a less direct route, which can lead to longer times for medication to take effect, according to a new study presented at the American College of Neuropsychopharmacology (ACNP) annual meeting.
Knowing how ketamine impairs brain circuitry may lead to new therapies for schizophrenia
Scientists know that the drug ketamine - street name "Special K" - can induce schizophrenia-like symptoms in drug abusers. Ketamine is also used as an anesthetic and, more recently, as an antidepressant - raising concerns by researchers at the University of California, San Diego (UCSD) School of Medicine, who have found that ketamine leads to the impairments in brain circuitry observed in both drug abusers and schizophrenic patients by causing increased production of a toxic free radical called "superoxide."
Faster-acting antidepressants closer to becoming a reality
A new study has revealed more about how the medication ketamine, when used experimentally for depression, relieves symptoms of the disorder in hours instead of the weeks or months it takes for current antidepressants to work.
Study suggests anesthetic agent may have rapid antidepressant effects
A single intravenous infusion of a drug known as ketamine, which is a general anesthetic agent, may relieve symptoms of depression within two hours and remain effective for up to one week.
Severe Pain Relief may be Possible with a Common Anesthetic Drug
A novel treatment using a common anesthetic drug has shown success in reducing the severe pain caused by Complex Regional Pain Syndrome (CRPS), according to a study published in the September 2004 issue of Pain Medicine. CRPS, a disorder that can be associated with chronic pain resistant to conventional therapies, affects between 1.5 and 7 million people in the United States. CRPS is sometimes also known as Reflex Sympathetic Dystrophy (RSD).
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