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Yes-associated protein: Early diagnosis of gastric carcinoma
September 16, 2009Yes-associated protein (YAP) is a type of cellular adaptor protein and transcriptional co-activator. In recent years, some investigators have found YAP to be overexpressed and highly activated in hepatic cancers and mammary cancers, suggesting its tumorigenicity. Survivin is a new member of the inhibitor of apoptotic protein (IAP) family, which was initially cloned by the cDNA of the effector cell protease receptor-1 in the human genomic library in 1997.
A research team led by Professor Yan Xin, from The Fourth Laboratory of Cancer Institute in China measured the expression of YAP and survivin in normal gastric mucosa, precancerous lesions and gastric carcinoma using an immunohistochemical method to analyze the significance and correlations of the 2 factors with gastric carcinogenesis. Their study will be published on August 28, 2009 in the World Journal of Gastroenterology.
The investigation found that the expression of YAP and survivin in gastric carcinoma were positively correlated, and according to the data, they speculated that YAP might induce a high expression of cell proliferation-related factors and apoptotic inhibitors, such as Ki67, cIAP1 and survivin. Survivin might participate in gastric carcinogenesis, progression and metastasis by inhibiting apoptosis of gastric carcinoma cells and regulating cellular mitosis. Whether YAP and survivin collaborate to contribute to gastric carcinogenesis and progression requires further study.
World Journal of Gastroenterology
World Journal of Gastroenterology
Gastric Carcinoma Current Events and Gastric Carcinoma News RSSPPAR-g agonists have potential therapeutic role in gastric carcinoma?
Recently, the potential of PPAR-γ as a target for the prevention and treatment of cancer has been widely studied.
Candidate markers for gastric cancer
The sequencing of the human genome has opened the door for proteomics by providing a sequence-based framework for mining proteomes.
A new insight on ethanol-induced gastric mucosa injury
Many people all over the world indulge themselves in drinking, which is correlated to a wide spectrum of medical, psychological, behavioral, and social problems.
U of T researchers reveal Epstein-Barr virus protein contributes to cancer
Researchers at the University of Toronto have discovered that the EBNA1 protein of Epstein-Barr virus (EBV) disrupts structures in the nucleus of nasopharyngeal carcinoma (NPC) cells, thereby interfering with cellular processes that normally prevent cancer development.
A potential route for human tumor gene therapy
The type 1 Na+/H+ exchanger (NHE1) is a transmembrane protein found in all eukaryotic cells. One of its functions is to evacuate excessive H+ in the cytoplasm by means of Na+-H+ exchange, resulting in stable intracellular pH value.
Gastric juice for diagnosis of H. pylori infection in patients on proton pump inhibitors
This study determined the efficiency of a gastric juice PCR test for the detection of H. pylori infection in patients receiving PPI therapy and compared it with histology and gastric biopsy PCR.
How is H pylori adhesion to gastric cells associated with MUC1 mucin VNTR size?
The Gram negative bacterium H pylori is involved in the pathogenesis of several gastrointestinal diseases, ultimately leading to gastric carcinoma. Adhesion of the bacteria to the gastric mucosa is an essential step for colonization and infection.
A new prognostic tool for gastric carcinomas? (and maybe other cancers)
A new way to identify gastric carcinoma patients with high probability of develop a more aggressive form of disease has just been described on the June issue of the journal Glycobiology.
Helicobacter pylori Acquisition Most Common In Young Children (P931)
A US study in this week's issue of THE LANCET highlights how most newly acquired infections of the intestinal bacterium Helicobacter pylori probably occur in children younger than 10 years of age. The authors of the study suggest that treatment and prevention strategies should therefore be targeted at young children. H pylori infection is associated with many gastro-intestinal disorders including gastritis, gastric ulcer, duodenal ulcer, gastric carcinoma, and primary gastric -cell lymphoma. H pylori is common worldwide, but the age at which it is acquired is unclear. Hoda Malaty and colleagues from Baylor College of Medicine, Houston, USA, studied 224 children (99 black, 125 white
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The Diversity of Gastric Carcinoma: Pathogenesis, Diagnosis and Therapy by M. Kaminishi (Editor), K. Takubo (Editor), K. Mafune (Editor) Japan has long been a leader of research into the carcinogenesis, pathology, diagnosis, and treatment of gastric carcinoma, which is still the second leading cause of cancer death worldwide. Distinguished experts in the field collaborated in creating this groundbreaking work, providing a comprehensive view of gastric cancer. This book encourages further development of gastric cancer research and its clinical application. Topics include all aspects of gastric carcinoma, such as the history of clinical and experimental gastric cancer research; updated issues of molecular and pathological research on gastric carcinogenesis; multidisciplinary methods in diagnosis, treatment, and chemotherapy; and perspectives in minimally invasive surgery. Color figures of histological specimens and other... |
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Stomach Rehabilitation Tablets (Wei Fu Chun Pian) by Hangzhou Hu Qing Yu Tang Stomach Rehabilitation Tablets (Wei Fu Chun Pian). Packing: 60 tablets (350mg each) / bottle. Manufactured by Hangzhou Hu Qing Yu Tang, China. Notes: This formula is based upon the ancient prescription of Chinese herbal practitioners. The combination of specific herbs helps get gastrointestinal functions back to normal. Pharmacological tests show the medicine can raise the immunity, improve the functions of the whole body and inhibit pylorus spirillum. Clinical experiments prove the medicine is indicated for chronic superficial gastritis, atrophied gastritis, intestinal metaplasia or untypical epithelial hyperplassia of gastric mucosa. It can relieve the clinical symptoms of functional indigestion, poor appetite, abdominal distention and stomach ache, weakness and fatigue, etc. It can... |
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PAT-2. Composite gastric carcinoma arising in a background of lymphocytic gastritis.(Section on Pathology): An article from: Southern Medical Journal by Mylinh T. Mac (Author), Salima Haque (Author) This digital document is an article from Southern Medical Journal, published by Southern Medical Association on October 1, 2004. The length of the article is 314 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: PAT-2. Composite gastric carcinoma arising in a background of lymphocytic gastritis.(Section on Pathology) Author: Mylinh T. Mac Publication: Southern Medical Journal (Refereed) Date: October 1, 2004 Publisher: Southern Medical Association Volume: 97 Issue: 10 Page: S63(1) Distributed by Thomson... | |
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Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine.(Clinical report): An article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology by J.-Y. Sun (Author), M.-Z. Zhu (Author), S.-W. Wang (Author), S. Miao (Author), Y.-H. Xie (Author), J.-B. Wang (Author) This digital document is an article from Phytomedicine: International Journal of Phytotherapy & Phytopharmacology, published by Thomson Gale on May 1, 2007. The length of the article is 3951 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Inhibition of the growth of human gastric carcinoma in vivo and in vitro by swainsonine.(Clinical report) Author: J.-Y. Sun Publication: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Magazine/Journal) Date: May 1, 2007 Publisher: Thomson Gale Volume: 14 Issue: 5 Page: 353(7) Article Type:... | |
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Gastric Carcinoma (Current Problems in Tumour Pathology) by M.I. Filipe (Author), Jeremy R. Jass (Author) | |
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Gastric Carcinoma: Classification, Diagnosis, and Therapy by Jürgen Hotz (Editor), Hans-Joachim Meyer (Editor), H.-J. Schmoll (Editor) Gastric Carcinoma/Classification, Diagnosis, and Therapy presents the most current perspective on gastric carcinoma, with particular emphasis on the surgical and chemotherapeutic modalities that offer hope for future treatment. The book discusses epidemiology, pathogenesis, and precancerous and clinical stage classification of the disease and provides valid practical guidelines for stage-specific diagnosis, therapy, and patient guidance. Topics explored include endoscopic criteria for premalignant lesions and early gastric carcinoma; clinical staging of gastric cancer by ultrasound, computerized tomography, and magnetic resonance tomography; surgical treatment of carcinomas of the gastroesophageal junction; possibilities for palliative treatment in surgical practice for advanced tumors;... | |
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Gastric Carcinoma Treated With H G L 504 by Nevil (SIGNED) LEYTON (Author) | |
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The American Journal of Surgery: General Technique of Operations For Gastric Carcinoma: (Volume XLV, No.1, July 1939 Pages 165-218) by MD and Edward M. Livingston, MD George T. Pack (Author) | |
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Special Aspects of the Therapy for Gastric Carcinoma (Digestive Surgery, Vol 11, No 2, 1994) by R. Kirchner (Editor) This text covers topics related to special aspects of the treatment of gastric cancer, including the extent of resection and of lymph node dissection, the mode of recurrence as well as efficacy of chemotherapy and intraoperative radiation. | |
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Carcinoma of the Esophagus and Gastric Cardia by Guo Jun Huang (Author), Wu Ying K'Ai (Editor) |
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