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Roles of S100A2 and p63 in the carcinogenesis of esophageal squamous cell carcinoma
September 17, 2009As a member of the S100 family, S100A2 is considered a candidate tumor-suppressor gene. Recently, p63 gene, a new member of the p53 gene family, has been studied in the fields of tumorigenesis, cell apoptosis and tissue growth. At present, few studies have been carried out on the expression and relationship of S100A2 and p63 in EC.
A research article to be published on September 7, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Professor Cao from Anhui Medical University, carried out a study which was based on in situ hybridization and immunohistochemical technology, to determine the expression of S100A2 and p63 in EC and their relationship to clinical pathological features，and to explore their roles in carcinogenesis and prognosis of EC.
The study showed that the expression of S100A2 protein was reduced and the expression of p63 protein was increased, and a negative correlation was observed between them. This indicated that S100A2 protein and p63 protein both play important roles in the carcinogenesis of EC. An investigation into the combined expression of S100A2 and p63 may be useful in early diagnosis and evaluating the prognosis of ESCC.
World Journal of Gastroenterology
World Journal of Gastroenterology
Researchers Identify Role of Gene in Tumor Development, Growth and Progression
Virginia Commonwealth University Massey Cancer Center and VCU Institute of Molecular Medicine researchers have identified a gene that may play a pivotal role in two processes that are essential for tumor development, growth and progression to metastasis.
Alcohol types and socioeconomic status are associated with Barrett's esophagus risk
Although the relationship between alcohol and esophageal squamous cell carcinoma is well established, studies investigating the association between alcohol intake and reflux esophagitis (RE), Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) have reported inconsistent findings.
A potential molecular target for biotherapy esophageal squamous cell carcinomas
The cadherin superfamily has a correlate relationship with the invasion and metastasis of carcinoma.
H. Pylori bacteria may help prevent some esophageal cancers
Some bacteria may help protect against the development of a type of esophageal cancer, known as adenocarcinoma, according to a new review of the medical literature. These bacteria, which are called Helicobacter pylori, live in the stomachs of humans.
More Esophageal Squamous Cell Carcinoma Current Events and Esophageal Squamous Cell Carcinoma News Articles
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Esophageal Cancer: An Overview.: An article from: MedSurg Nursing by Jo Ann Brooks-Brunn (Author) This digital document is an article from MedSurg Nursing, published by Jannetti Publications, Inc. on October 1, 2000. The length of the article is 5165 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: Esophageal cancer is the second most common solid intrathoracic malignancy behind lung cancer. Treatment of esophageal cancer is dependent upon the stage of presentation and the options include chemotherapy, radiation therapy, surgery, multimodality therapy, or palliative care. Early detection of this disease is the primary method to decrease its high morbidity and... |
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