Science Current Events | Science News | Brightsurf.com
 

Molecular imaging holds promise for early intervention in common uterine cancer

October 01, 2009
Combined molecular imaging technique effectively evaluates and predicts tumor's course

Reston, Va.-A promising new molecular imaging technique may provide physicians and patients with a noninvasive way to learn more information about a type of cancer of the uterus lining called "endometrial carcinoma"-one of the most common malignant female tumors. This research was presented in a study published in the October issue of The Journal of Nuclear Medicine.

"Endometrial carcinoma is one of the most common female malignant tumors," says Hidehiko Okazawa, M.D., Ph.D., professor in the division of medical imaging at the biomedical imaging research center at the University of Fukui in Japan and one of the lead researchers of the study. "The method of positron emission tomography (PET) imaging we used in the study is noninvasive, and it has tremendous potential to save women with endometrial carcinoma from undergoing unnecessary operations and biopsies that could sabotage their reproductive potential."

If the disease is caught early enough, the five-year survival rate is higher than 90% for patients with endometrial carcinoma. PET imaging may provide physicians with a tool that lets them recognize the extent of the disease before it reaches advanced stages.

This study shows that PET is a promising molecular imaging technique for personalized therapy. Molecular imaging and nuclear medicine provide the possibility of determining the invasiveness and aggressiveness of malignant tumors in the uterus earlier on, before disease progresses. With this technique, physicians gain the advantage of a more precise diagnosis along with the ability to better predict the tumor's growth patterns and plan for the most appropriate therapeutic treatment strategy.

"The article in the JNM from Dr. Tsujikawa and colleagues provides an example of the unique capacity of molecular imaging to measure in vivo cancer biology," says David A. Mankoff, M.D., Ph.D., professor of radiology, medicine and bioengineering at the University of Washington and Seattle Cancer Care Alliance in Seattle. "Most notably, it shows how imaging multiple facets of tumor phenotype-in this case, estrogen receptor expression and glucose metabolism-can provide insight into the clinical behavior of cancer. The broad implication of this study, and other similar studies that have tested PET and molecular imaging to characterize cancer characteristics, is that imaging can help direct cancer patients toward optimized, individualized treatments."

In the study, the researchers used a specialized form of PET imaging called "estrogen receptor expression imaging" for 22 patients with endometrial adenocarcinoma and nine patients with endometrial hyperplasia (a thickening of the uterine lining that is a risk factor for developing endometrial cancer) to evaluate diagnostic accuracy. All patients underwent preoperative PET scans with 18F-fluoroestradiol (18F-FES)-a tracer that has been successfully used in diagnosing breast cancer-and 18F-fluorodeoxyglucose (18F-FDG) to compare differences in tracer accumulation.

The researchers confirmed that endometrial carcinoma reduces estrogen dependency with accelerated glucose metabolism as it progresses to a higher stage or grade. By combining the two tracers, researchers were able to use a new index of uptake ratio that can better predict pathologic stages and aggressiveness of tumors. The results of the study were encouraging, with the combined techniques having 86% accuracy.

For endocrine-related tumors (including endometrial cancer), tumors vary from well-differentiated and close in character to the tissue of origin to poorly differentiated tumors, which are aggressive and bear less resemblance to the tissue of origin. The well-differentiated tumors tend to be more slow-growing and less aggressive than poorly differentiated tumors. They also retain their endocrine function and/or responsiveness.

For endometrial cancer, estrogen receptor expression is related to endocrine responsiveness and indicated by FES uptake. Poorly differentiated tumors often have increased and abnormal breakdown of glucose, indicated by FDG. The combination of the two, as indicated by the study, was better than either alone at indicating the aggressiveness of the tumor.

Personalized cancer therapy involves treatment that is individualized for patients based on patient characteristics and the tumor's biology. By studying the tumor's properties, physicians can predict the tumor's path and formulate the best strategy for treating the disease.

Society of Nuclear Medicine


Related Endometrial Carcinoma Current Events and Endometrial Carcinoma News Articles


Genetic 'hotspot' linked to endometrial cancer aggressiveness
Parents of twins often tell them apart through subtle differences such as facial expression, moles, voice tone and gait.

Aromatase inhibitors increased risk of heart disease in postmenopausal women with breast cancer
Postmenopausal women who take aromatase inhibitors as a treatment for breast cancer may be at an increased risk for developing cardiovascular disease, according to the results of a meta-analysis.

New research findings may enable earlier diagnosis of uterine cancer
Cancer is a genetic disease. It occurs when changes take place in the genes that regulate cell division, cell growth, cell death, cell signalling and blood vessel formation - either due to mutations caused by external factors such as smoking or radiation - or due to inherited changes.
More Endometrial Carcinoma Current Events and Endometrial Carcinoma News Articles

Advances in Surgical Pathology: Endometrial Carcinoma

Advances in Surgical Pathology: Endometrial Carcinoma
by Anna Sienko MD (Author)


Part of the popular Advances in Surgical Pathology Series, this volume is a concise, updated review of the pathological characteristics of endometrial cancer. It emphasizes the histologic correlation, clinical management, and treatment of endometrial cancer, and features current and emerging concepts in the field. The book provides a resource for the timely updates in knowledge that are necessary for daily practice, for current credentialing, and for the self-assessment modules for recertification (MOC).

A free companion web site features fully searchable text as well as over 130 full-color images.

Endometrial Carcinoma

Endometrial Carcinoma
by Shen-yi Li (Author), En-yu Wang (Author), Shen-yi Li (Translator), En-yu Wang (Translator), Michihiro Seta (Translator)


During the past 20 years, endometrial carcinoma has continued to increase in frequency and it is quite possible that this carcinoma will become the major gynecologic malignancy in the future. For many years, endometrial carcinoma was considered less malignant than other gynecologic malignancies, simple hysterectomy and bil­ ateral salpingo-oophorectomy or surgery combined with radiation being effective in certain circumstances. It is unfortunate to note that the global 5-year survival rate for patients with advanced or recurrent endometrial carcinoma has improved only slightly. Therefore any complacency regarding this 'benign malignancy' should be reconsidered. There is a growing awareness of the nature of end­ ometrial carcinoma, with advances in our knowledge ranging from its etiology...

Cell and Molecular Biology of Endometrial Carcinoma

Cell and Molecular Biology of Endometrial Carcinoma
by Hiroyuki Kuramoto (Editor), M. Nishida (Editor)


The 15th International Symposium of the Japan Human Cell Society on Cell and Molecular Biology of Endometrial Carcinoma brought together leading researchers from Japan and around the world. The papers collected here are the work of twenty-two leaders in their field and are organized in ten major categories. The first section, in vitro experimental systems, takes up the pioneering work by Kuramoto in 1968 and Nishida in 1980 in establishing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma cell lines. Other topics include apoptosis, proliferation, and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. Presenting...

First Aid for the USMLE Step 1 2015 (First Aid USMLE)

First Aid for the USMLE Step 1 2015 (First Aid USMLE)
by Tao Le (Author), Vikas Bhushan (Author)


THE 25th EDITION OF THE WORLD'S MOST POPULAR MEDICAL REVIEW BOOK! Trust 25 years of experience for the most effective USMLE Step 1 preparation possible 1,250+ must-know topics provide a complete framework for your USMLE preparation Test-taking advice with focus on high-efficiency studying Major revisions in all subject areas based on feedback from thousands of students Free real-time updates and corrections at www.firstaidteam.com Extensive faculty review process with nationally known USMLE instructors 1,000+ color photos and diagrams help you visualize high-yield concepts Expanded guide to high-yield study resources, including mobile apps INSIDER ADVICE FOR STUDENTS FROM STUDENTS

Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix

Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix
by Rhonda Yantiss MD (Author)


Advances in Surgical Pathology: Colorectal Carcinoma and Tumors of the Vermiform Appendix, a volume in the Advances in Surgical Pathology series, features chapters on current and impending changes in the field with an emphasis on practical issues, recent developments, and emerging concepts.Created as a quick review to be used during pathologic evaluation of cancer specimens from the lower gastrointestinal tract, this book contains the latest information regarding emerging endoscopic techniques that aid in tumor classification and staging, mechanisms of pathogenesis, and clinical management. It combines gross and microscopic images and user-friendly tables for quick reference with a succinct, comprehensive review of issues important to management of patients with colorectal carcinoma. Not...

Endometrial Cytology with Tissue Correlations (Essentials in Cytopathology)

Endometrial Cytology with Tissue Correlations (Essentials in Cytopathology)
by John A. Maksem (Author), Stanley J. Robboy (Author), John W. Bishop (Author), Isabelle Meiers (Author)


As compared with cytology’s use in other organ systems, direct cytological examination of the endometrium is not a widely practiced diagnostic procedure. This is an anomaly, because the endometrium is exceedingly available for cytological sampling, cytological sampling is comparably simple to perform, and, from the patient’s perspective, it is a gentle procedure as compared to other methods of specimen attainment. Over the years, as we personally gained more and more experience with specimen acquisition, processing and interpretation, we have come to look upon endometrial cytology as an effective method for ensuring endometrial normalcy and discovering and diagnosing malignant and premalignant states. In comparing endometrial cytology to endometrial biopsy, we have found that, in...

Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach

Diagnosis of Endometrial Biopsies and Curettings: A Practical Approach
by Michael Mazur (Author), Robert J. Kurman (Author)


Derived from the authors' long-running course presented at the International Academy of Pathology, this second edition, now with color illustrations, continues the tradition of its predecessor as being the concise and complete diagnostic guide to the endometrial biopsy. The text is structured so as to present a logical approach to formulating a pathologic diagnosis from the diverse array of tissue received in the surgical pathology laboratory. Color illustrations show typical artifacts and distortion, and explain their impact on diagnostic interpretation. Each chapter includes a section summarizing the features that must be discussed in the final pathology report.

Endometrial Cancer (Cancer Treatment and Research)

Endometrial Cancer (Cancer Treatment and Research)
by Earl A. Surwit (Editor), David Alberts (Editor)


The incidence of endometrial cancer rose sharply in the United States in the early 1970s, paralleling changes in the use of postmenopausal estrogens by American women. A sizeable body of evidence supports the role of both excessive endogenous estrogen and exogenous estrogen in the etiology of endometrial cancer. There is growing evidence that inadequate progesterone has the opposite effect, in that progesterone supplementation of postmeno­ pausal estrogen therapy reduces the incidence of endometrial cancer. Despite this new awareness of the hormonal role that is played in carcino­ ma of the endometrium, the disease still plagues the oncologist. The general approach to carcinoma of the endometrium in the United States is that of primary surgical staging. This provides the maximum amount...

Master the Boards USMLE Step 3

Master the Boards USMLE Step 3
by Conrad Fischer MD (Author)


Targeted Step 3 in full color—updated for the 2015 exam change 

Fully updated to the 2015 exam change, Master the Boards USMLE® Step 3 helps you identify highly tested concepts, sharpen recall, and recognize the most likely answer on the test. With exclusive test-day tips and targeted review from USMLE expert Conrad Fischer, MD, this full-color review book ensures there are no surprises on test day.

FEATURES:

NEW! Just enough basic science for the exam
NEW! Patient safety notes
Exam-like focus on best initial diagnostic test, most accurate test, & most likely diagnosis
Step-by-step approach to diagnosis & management
Page-by-page links to the comprehensive Kaplan USMLE Step 3 QBank
Practical CCS tips
 

A Simple Guide to Uterine Cancer, Diagnosis and Treatment (A Simple Guide to Medical Conditions)

A Simple Guide to Uterine Cancer, Diagnosis and Treatment (A Simple Guide to Medical Conditions)


Introduction

Ode to Uterine Cancer

No one wants cancer or his body cell to becomes mutant
But when the body mutates and become malignant
There is nothing much that you can do about it
All you do is hope the cancer cells can be removed by surgery

The other treatments in the past is radiation or chemotherapy
Now there are stem cells, hormone treatment and immunotherapy
Targeted therapy is focused directly on a particular cluster of cancer cells
The exact location where the cancer cells dwell

Avoid smoking if possible; cigarette smoke has 40 types of carcinogens
Avoid alcohol which can cause cancer of mouth, eosphagus and liver conditions
Avoid chemicals like asbestos, alphatoxins from nuts...

© 2014 BrightSurf.com