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Aspirin Misuse May Have Made 1918 Flu Pandemic Worse
October 05, 2009The devastation of the 1918-1919 influenza pandemic is well known, but a new article suggests a surprising factor in the high death toll: the misuse of aspirin. Appearing in the November 1 issue of Clinical Infectious Diseases and available online now, the article sounds a cautionary note as present day concerns about the novel H1N1 virus run high.
High aspirin dosing levels used to treat patients during the 1918-1919 pandemic are now known to cause, in some cases, toxicity and a dangerous build up of fluid in the lungs, which may have contributed to the incidence and severity of symptoms, bacterial infections, and mortality. Additionally, autopsy reports from 1918 are consistent with what we know today about the dangers of aspirin toxicity, as well as the expected viral causes of death.
The motivation behind the improper use of aspirin is a cautionary tale, said author Karen Starko, MD. In 1918, physicians did not fully understand either the dosing or pharmacology of aspirin, yet they were willing to recommend it. Its use was promoted by the drug industry, endorsed by doctors wanting to "do something," and accepted by families and institutions desperate for hope.
"Understanding these natural forces is important when considering choices in the future," Dr. Starko said. "Interventions cut both ways. Medicines can save and improve our lives. Yet we must be ever mindful of the importance of dose, of balancing benefits and risks, and of the limitations of our studies."
HIV Medicine Association
"Understanding these natural forces is important when considering choices in the future," Dr. Starko said. "Interventions cut both ways. Medicines can save and improve our lives. Yet we must be ever mindful of the importance of dose, of balancing benefits and risks, and of the limitations of our studies."
HIV Medicine Association
Aspirin Current Events and Aspirin News RSSEarly end to key study on benefits of niacin, a B vitamin, in keeping arteries open was premature
Heart experts at Johns Hopkins are calling premature the early halt of a study by researchers at Walter Reed Army Medical Center and Washington Hospital Center on the benefits of combining extended-release niacin, a B vitamin, with cholesterol-lowering statin medications to prevent blood vessel narrowing.
Common Pain Relievers May Dilute Power of Flu Shots
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers - Advil, Tylenol, aspirin - at the time of injection may blunt the effect of the shot and have a negative effect on the immune system.
News brief: Effects of aspirin and folic acid on inflammation markers for colorectal adenomas
Unexpectedly, inflammation markers do not appear to be involved with the chemopreventative effect of aspirin on colorectal adenomas, according to a brief communication published online October 12 in the Journal of the National Cancer Institute.
Cogent trial shows lack of adverse interaction between clopidogrel and stomach medicine
Results from a late breaking clinical trial called COGENT demonstrate that the combination of giving patients clopidogrel, a blood thinner commonly prescribed to patients with cardiovascular disease, and stomach medicines such as omeprazole, known as proton pump inhibitors (PPIs), did not lead to adverse events, as some prior studies had suggested.
Aspirin works for primary prevention in moderate and high risk diabetics
The beneficial effects of aspirin in primary prevention of cardiovascular events i.e. stroke, MI and cardiac death are known and generally accepted.
New strategies for reperfusion therapy
A new trial has begun in order to ascertain once and for all whether the best strategy for patients who cannot receive P-PCI is early fibrinolysis, together with mandated angiography.
Small peptide found to stop lung cancer tumor growth in mice
In new animal research done by investigators at Wake Forest University School of Medicine, scientists have discovered a treatment effective in mice at blocking the growth and shrinking the size of lung cancer tumors, one of the leading causes of cancer death in the world.
Genetic variation associated with poorer response, cardiovascular outcomes with use of clopidogrel
Patients with a certain genetic variation who received the antiplatelet drug clopidogrel had a decreased platelet response to treatment and among those who had percutaneous coronary intervention (procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries) had an increased risk of having a cardiovascular event in the following year than patients who did not have this variant, according to a study in the August 26 issue of JAMA.
Study reveals mounting evidence of fish oil's heart health benefits
There is mounting evidence that omega-3 fatty acids from fish or fish oil supplements not only help prevent cardiovascular diseases in healthy individuals, but also reduce the incidence of cardiac events and mortality in patients with existing heart disease.
Link between migraines and reduced breast cancer risk confirmed in follow-up study
The relationship between migraine headaches in women and a significant reduction in breast cancer risk has been confirmed in a follow-on study to landmark research published last year and conducted by scientists at Fred Hutchinson Cancer Research Center.
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Bayer Low Dose 81 mg Aspirin Regimen-400 Tablets by Bayer Safety Coated "Baby" Aspirin - Aspirin Regimen For Adult Use * Often Recommended as "Baby" Aspirin by Doctors for Adult Aspirin Regimen Use * Small, Easy-To-Swallow Tablets * Safety Coated for Added Stomach Protection * Aspiring Protects Your Heart by Keeping Your Blood Flowing Freely For the temporary relief of minor aches and pains or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief. Ask your doctor about other uses for Safety Coated 81 mg Aspirin. |
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Low Dose Aspirin (enteric coated) 81mg 500 Tablets by Life Extension Numerous studies document the multiple health benefits of daily low dose aspirin. Aspirin helps to maintain normal platelet aggregation in blood vessels and the production of prostaglandin E2 and possibly C-reactive protein. |
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Bayer Aspirin Pain Reliever/ Fever Reducer, 300-Count Coated Tablets (Pack of 2) by Bayer Pain Reliever/Fever Reducer. Fast, safe pain relief Plus the life saving benefits of aspirin. Headaches; Everyday aches and pains. Doctor recommended for Aspirin Regimen Use. Aspirin is not appropriate for everyone, so be sure to talk to your doctor befor |
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Bayer Aspirin Pain Reliever/ Fever Reducer, Low Dose Safety Coated for Baby (81 mg), 200-Count Enteric Coated Tablets (Pack of 2) by Bayer It is most often used by patients who are taking aspirin on a regular basis under a doctor's supervision. This product contains one-quarter the medicine of a regular strength aspirin tablet allowing you to more conveniently take the dosage directed by you |
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Bayer Aspirin Pain Reliever/ Fever Reducer, Extra Strength PLUS, 50-Count Caplets (Pack of 4) by Bayer Aspirin PLUS a "Buffer" to guard against upset stomach, Use for the temporary relief of headache, muscle pain, toothache, pain and fever of colds, menstrual pain, minor pain of arthritis |
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Bayer Genuine Aspirin 325mg 500 tablets by Bayer THE WONDER DRUG Fast, Safe Pain Relief Plus The Life Saving Benefits of Aspirin Uses temporarily relieves headache menstrual pain muscle pain pain and fever of colds toothache minor pain of arthritis Directions: Active Ingredients (in each tablet): Inactive Ingredients: *May contain this ingredient. Warnings: |
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