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Curcumin may inhibit nicotine-induced activation of head and neck cancers
October 05, 2009New research released at world's largest ENT meeting
San Diego, CA - Curcumin, the compound that gives curry powder its yellow/orange color, may inhibit the adverse effects of nicotine in patients with head and neck cancer who continue to smoke.
In a paper presented at the 2009 American Academy of Otolaryngology - Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO in San Diego, researchers examined the effects of curcumin on head and neck squamous cell carcinoma (HNSCC) growths. The study used an in vitro model of a variety of head and neck cancer cell lines. To mimic the clinical situation, HNSCC cells were pre-treated with curcumin and then nicotine was introduced. The results of the studies showed that the curcumin was able to block the nicotine from activating cancer causing cells.
Annually there are approximately 40,000 new cases of head and neck cancers and 13,000 deaths in the U.S. and 500,000 new cases worldwide. Recurrence of these cancers are high because many patients continue to smoke after successful treatment. Also, former smokers often use nicotine replacement therapy as an aid for successful tobacco cessation.
Although nicotine itself has not been shown to be carcinogenic, it has been shown to encourage the cancer-forming process. The researchers sought a safe, bioactive food compound that could be used not only as a chemopreventive agent but could also block the harmful effects of nicotine.
The results may help to discover additional therapies for cancer prevention and treatment.
American Academy of Otolaryngology -- Head and Neck Surgery
Annually there are approximately 40,000 new cases of head and neck cancers and 13,000 deaths in the U.S. and 500,000 new cases worldwide. Recurrence of these cancers are high because many patients continue to smoke after successful treatment. Also, former smokers often use nicotine replacement therapy as an aid for successful tobacco cessation.
Although nicotine itself has not been shown to be carcinogenic, it has been shown to encourage the cancer-forming process. The researchers sought a safe, bioactive food compound that could be used not only as a chemopreventive agent but could also block the harmful effects of nicotine.
The results may help to discover additional therapies for cancer prevention and treatment.
American Academy of Otolaryngology -- Head and Neck Surgery
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Jarrow Formulations Curcumin-95, 500 mgs, 120 Capsules by Jarrow Formulations Curcumin 95 is an 18:1 extract of the antioxidants found in the spice turmeric root. Curcumin 95 contains 95% curcuminoids (including curcumin, demethoxycurcumin and bisdemethoxycurcumin), which are antioxidants. Specifically, curcumin and its derivatives protect DNA against oxidative damage induced by singlet oxygen. Turmeric in Latin is Curcuma longa. The roots of the plant are stemlike and are used as an herb in Asian cooking such as in making curries. * Picture may be of different size or flavor |
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Now Foods Curcumin Extract 95% 700mg, 60 Capsules by NOW "Curcumin is the major component of Turmeric (Curcuma longa L.) and extensive scientific research on Curcumin has demonstrated its potent antioxidant properties. Through its antioxidant mechanisms, Curcumin supports colon health, exerts neuroprotective activity and helps maintain a healthy cardiovascular system." |
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Super Curcumin w/ Bioperine 800mg - 60 - Capsule by Life Extension Super Curcumin with Bioperine®800 mg, 60 capsulesItem Catalog Number: 912 Curcumin was first used by Indians over 3000 years ago in traditional Ayurvedic medicine. Modern science has found that this extract from the common spice turmeric has remarkable qualities as an antioxidant.82-84 Over time, as our cells continue to be affected by free radicals, or oxidants, organs begin to degenerate and aging accelerates. The body has built-in defense mechanisms to protect itself from free radical damage, but eventually, aging depletes the bodys ability to keep oxidants at bay. Curcumin can also help maintain normal healthy platelet function and the normal process of bile excretion.85-87 New studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa beta... |
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Nature's Bounty Turmeric/Curcumin, 60 Capsules (Pack of 2) by Nature's Bounty Herbal Supplement. With Turmeric extract standardized to 95% curcuminoids. Contains antioxidants. The active ingredients in Turmeric include beneficial flavanoids called Curcuminoids, which are plant based antioxidants. Antioxidants help fight cell-damagi |
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Curcumin 120 vcaps by NOW Curcumin is the major component of Turmeric (Curcuma longa L.) and extensive scientific research on Curcumin has demonstrated its potent antioxidant properties. Through its antioxidant mechanisms, Curcumin supports colon health, exerts neuroprotective activity and helps maintain a healthy cardiovascular system. * Picture may be of different size or flavor |
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Best Curcumin with BioPerine 120 caps by DOCTOR'S BEST Best Curcumin w/Bioperine contains a standardized extract of Curcuma longa root, commonly known as Turmeric. Turmeric is a yellow spice used in curried dishes. In the Far East, turmeric is valued for more than just its culinary applications. The herb has been employed in the Ayurvedic healing tradition for centuries , and is a common household remedy in India. The active ingredients in Curcuma longa are a group of plant substances called curcuminoids. Known collectively as curcumin, curcuminoids have demonstrated potent antioxidant properties in scientific studies.* Curcuminoids benefit joints and other tissues by helping to neutralize free-radicals.* Curcuminoids are responsible for turmerics distinctive yellow color. * Picture may be of different size or flavor |
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Source Naturals Turmeric Extract, Tablets, 100 tablets (Pack of 2) by Source Naturals Dietary supplement. Standardized to 95% Curcumin. Curcumin considered the most bioactive and soothing portion of the herb turmeric, shows protective effects on the liver. It also inhibits the COX-II enzyme and is a powerful antioxidant. When take alone, c |
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Turmeric 720 mg 100 Caps by Swanson Premium Brand Protect your digestive system and liver with the natural nutrition of turmeric! Chefs may be most familiar with turmeric as a spice used in curries, but herbalists know it as an outstanding natural tonic for the liver and gastrointestinal system. The key to turmeric's benefits appear to be its high concentration of natural compounds known as curcuminoids, which possess powerful antioxidant capabilities. |
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Super Bio Curcumin BCM 95 - 60 - Capsule by Life Extension Super Bio-Curcumin® 400 mg, 60 vegetarian capsules Curcumin was first used by Indians over 3000 years ago in traditional Ayurvedic medicine. Modern science has found that this extract from the common spice turmeric has remarkable qualities as an antioxidant.82-84 Over time, as our cells continue to be affected by free radicals, or oxidants, organs begin to degenerate and aging accelerates. The body has built-in defense mechanisms to protect itself from free radical damage, but eventually, aging depletes the bodys ability to keep oxidants at bay. Curcumin can also help maintain normal healthy platelet function and the normal process of bile excretion.85-87 New studies have tied inflammation to overexpression of a protein molecule called... |
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Curcumin 500mg 95% 60 Capsules by Jarrow Formulas Curcumin 95TM is an 18:1 extract of the antioxidants found in the spice turmeric root. Turmeric in Latin is Curcuma longa. The roots of the plant are stemlike and are used as an herb in Asian cooking such as curries |
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