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OU Part of International Study on Genetic Impact of Radiation
October 08, 2009Oklahoma City, OK -- Researchers at the University of Oklahoma Health Sciences Center are helping to lead a massive international study on the possible genetic effects of radiation and cancer drug exposures on future generations. The study's principal investigators are meeting this week at the OU Health Sciences Center to discuss their recent findings, which will be presented at an upcoming meeting of the American Society of Human Genetics.
The study, which combines cancer survivors in the United States and Scandinavia, is looking at potential genetic consequences of reproductive organs exposed to curative therapy by drugs or radiation. Scientists want to determine whether radiation and chemotherapy before conception increases the occurrence of birth defects, stillbirths and specific conditions such as Down syndrome. They also want to know if radiation treatment leads to cancer or DNA damage in the patients' offspring. It is the first and largest study of its kind.
In Denmark and Finland, researchers have been able to identify all cancer survivors since 1943 and 1952, respectively, who had cancer before age 35. They also documented the nearly 20,000 children produced by the survivors. Scientists now want to compare their findings with patients in the United States.
"So far, the results have been encouraging," said John J. Mulvihill, M.D., one of the leaders of the study and a renowned geneticist at the OU College of Medicine and the OU Cancer Institute. "This study is important for many reasons, but most notably for cancer survivors who need reassurances that their children will not be affected by their chemotherapy and radiation treatment. This research also will help families in Hiroshima and Chernobyl where residents were exposed to high levels of radiation as children and young adults."
In addition to the University of Oklahoma Health Sciences Center, seven top cancer research centers worldwide are participating in the study.
University of Oklahoma
"So far, the results have been encouraging," said John J. Mulvihill, M.D., one of the leaders of the study and a renowned geneticist at the OU College of Medicine and the OU Cancer Institute. "This study is important for many reasons, but most notably for cancer survivors who need reassurances that their children will not be affected by their chemotherapy and radiation treatment. This research also will help families in Hiroshima and Chernobyl where residents were exposed to high levels of radiation as children and young adults."
In addition to the University of Oklahoma Health Sciences Center, seven top cancer research centers worldwide are participating in the study.
University of Oklahoma
Radiation Current Events and Radiation News RSSExperts: Failure to focus on farming will undermine global climate agreement and increase hunger
Alarmed by a substantial oversight in the global climate talks leading up to the United Nations Climate Change Conference in Copenhagen next month, more than 60 of the world's most prominent agricultural scientists and leaders underscored how the almost total absence of agriculture in the agreement could lead to widespread famine and food shortages in the years ahead.
Extinct moa rewrites New Zealand's history
DNA recovered from fossilised bones of the moa, a giant extinct bird, has revealed a new geological history of New Zealand, reports a study published this week in the Proceedings of the National Academy of Sciences.
New explanation for nature's hardiest life form
Got food poisoning? The cause might be bacterial spores, en extremely hardy survival form of bacteria, a nightmare for health care and the food industry and an enigma for scientists.
Working together to design robust silicon chips
Designers of high-speed silicon chips have often had to compromise on performance levels for their integrated circuit designs because of physical weaknesses appearing during design verification or even in production.
ESA spacecraft may help unravel cosmic mystery
When Europe's comet chaser Rosetta swings by Earth tomorrow for a critical gravity assist, tracking data will be collected to precisely measure the satellite's change in orbital energy. The results could help unravel a cosmic mystery that has stumped scientists for two decades.
Nanotech in Space: Rensselaer Experiment To Weather the Trials of Orbit
Novel nanomaterials developed at Rensselaer Polytechnic Institute are scheduled to blast off into orbit on November 16 aboard Space Shuttle Atlantis.
A bubbling ball of gas
The Sun is a bubbling mass. Packages of gas rise and sink, lending the sun its grainy surface structure, its granulation. Dark spots appear and disappear, clouds of matter dart up - and behind the whole thing are the magnetic fields, the engines of it all.
Iowa State engineers develop 3-D software to give doctors, students a view inside the body
James Oliver picked up an Xbox game controller, looked up to a video screen and used the device's buttons and joystick to fly through a patient's chest cavity for an up-close look at the bottom of the heart.
Men leave: Separation and divorce far more common when the wife is the patient
A woman is six times more likely to be separated or divorced soon after a diagnosis of cancer or multiple sclerosis than if a man in the relationship is the patient, according to a study that examined the role gender played in so-called "partner abandonment." The study also found that the longer the marriage the more likely it would remain intact.
Drought resistance explained
Much as adrenaline coursing through our veins drives our body's reactions to stress, the plant hormone abscisic acid (ABA) is behind plants' responses to stressful situations such as drought, but how it does so has been a mystery for years.
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