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Radiologists develop scale to help clinicians predict disease severity in infants with NEC
October 21, 2009Radiologists at Duke University Medical Center have developed a scale called the Duke Abdominal Assessment Scale (DAAS) to assist clinicians in determining the severity of disease and the need for surgery in infants with necrotizing enterocolitis (NEC), according to a study in the November issue of the American Journal of Roentgenology.
NEC is a serious disease that causes infection and inflammation of the intestines in infants, primarily those that are premature. Its cause is unknown however it is one of the leading causes of surgical intervention in preemies and has a death rate of 25 percent.
"The DAAS provides a standardized 10-point radiographic scale that increases with disease severity," said Caroline L. Hollingsworth, M.D., lead author of the study. For every 1-point increase in the DAAS score, patients are more likely to have severe disease and more likely to need a surgical intervention," she said.
Researchers performed a case-control study of 43 infants to assess whether the DAAS could serve as a clinically useful tool for predicting disease severity in neonates and infants with clinically suspected NEC. "We found that the use of a standardized scale like the DAAS may enable earlier detection of patients at risk for developing severe NEC by creating a clear, concise radiology report that provides the clinician with a consistent measure of concern by the radiologist. We also found that improved communication through standardized reporting using an accurate scale like the DAAS may affect medical decision making in a positive way and hasten the accurate identification of patients in need of intense medical surveillance or surgical intervention," said Dr. Hollingsworth.
"Our study suggests that using the DAAS score when interpreting abdominal X-rays in neonates and infants with clinically suspected NEC may help guide increased level of clinical concern and monitoring for advanced NEC. Radiographic monitoring of disease progression and heightened clinical awareness through improved communication via the DAAS system has been a tremendous help to our clinicians at Duke," she said.
American Roentgen Ray Society
Researchers performed a case-control study of 43 infants to assess whether the DAAS could serve as a clinically useful tool for predicting disease severity in neonates and infants with clinically suspected NEC. "We found that the use of a standardized scale like the DAAS may enable earlier detection of patients at risk for developing severe NEC by creating a clear, concise radiology report that provides the clinician with a consistent measure of concern by the radiologist. We also found that improved communication through standardized reporting using an accurate scale like the DAAS may affect medical decision making in a positive way and hasten the accurate identification of patients in need of intense medical surveillance or surgical intervention," said Dr. Hollingsworth.
"Our study suggests that using the DAAS score when interpreting abdominal X-rays in neonates and infants with clinically suspected NEC may help guide increased level of clinical concern and monitoring for advanced NEC. Radiographic monitoring of disease progression and heightened clinical awareness through improved communication via the DAAS system has been a tremendous help to our clinicians at Duke," she said.
American Roentgen Ray Society
Necrotizing Enterocolitis Current Events and Necrotizing Enterocolitis News RSSPackard/Stanford study suggests two causes for bowel disease in infants
New research from Lucile Packard Children's Hospital and the Stanford University School of Medicine is helping physicians unravel the cause of a deadly and mysterious bowel disease that strikes medically fragile newborn babies.
Children's Hospital researchers identify molecular 'switch' that could save very young lives
A team of researchers at Children's Hospital of Pittsburgh of UPMC have identified a molecular "switch" that, when blocked, may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature infants.
Leading cause of death in 'preemies' might be controlled by resetting a molecular switch
Blocking signals from a key molecular receptor that normally switches on the intestine's immune response but instead becomes too intense in the presence of stress and toxins may help reverse necrotizing enterocolitis (NEC), a leading cause of death in premature newborns.
Pathway to cell death redefined in landmark study
A new study led by investigators from the University of Pittsburgh School of Medicine demonstrates that the process of necrosis, long thought to be a chaotic, irreversible pathway to cell death, may actually be triggered as part of a regulated response to stress by a powerful protein, SRP-6, that can potentially halt necrosis in its path.
Two very different surgical procedures produce same results in often fatal intestinal disorder
Two surgical procedures, one invasive and the other much less so, for premature infants with intestinal perforation due to necrotizing enterocolitis (NEC) produce virtually identical results, according to a Yale School of Medicine study published today in the New England Journal of Medicine.
First trial on life-threatening condition finds 2 surgical approaches have same results
A nationwide clinical trial involving researchers at Children's Hospital of Pittsburgh compared two radically different surgical procedures to treat an often fatal intestinal disorder in premature infants and found nearly identical results.
Common reflux treatment linked to life threatening bowel infection in premature infants
Researchers in an NIH network have found that premature infants given a common class of non-prescription drugs used to treat acid reflux are slightly more likely to develop a potentially fatal bowel disorder than are infants who are not treated with the drugs.
More Necrotizing Enterocolitis Current Events and Necrotizing Enterocolitis News Articles
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G6PD deficiency tied to necrotizing enterocolitis.(glucose-6-phosphate dehydrogenase deficiency): An article from: Pediatric News by Michele G. Sullivan (Author) This digital document is an article from Pediatric News, published by Thomson Gale on April 1, 2007. The length of the article is 519 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: G6PD deficiency tied to necrotizing enterocolitis.(glucose-6-phosphate dehydrogenase deficiency) Author: Michele G. Sullivan Publication: Pediatric News (Magazine/Journal) Date: April 1, 2007 Publisher: Thomson Gale Volume: 41 Issue: 4 Page: 16(1) Distributed by Thomson... | |
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Necrotizing enterocolitis: An entry from Thomson Gale's Gale Encyclopedia of Children's Health: Infancy through Adolescence by Caroline Helwick (Author), Deborah, MS Nurmi (Author) Avoiding hard-to-understand medical jargon, the four-volume “Gale Encyclopedia of Children’s Health” uses language that parents can understand, while still providing enough depth to benefit today's health science students. The set provides in-depth coverage of pediatric diseases and disorders, along with issues related to physical and cognitive/behavioral development. | |
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Antibiotics linked to necrotizing enterocolitis.(INFECTIOUS DISEASES): An article from: Pediatric News by Michele G. Sullivan (Author) This digital document is an article from Pediatric News, published by International Medical News Group on February 1, 2009. The length of the article is 656 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser. Citation Details Title: Antibiotics linked to necrotizing enterocolitis.(INFECTIOUS DISEASES) Author: Michele G. Sullivan Publication: Pediatric News (Magazine/Journal) Date: February 1, 2009 Publisher: International Medical News Group Volume: 43 Issue: 2 Page: 7(1) Distributed by Gale, a part of Cengage... | |
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Neonatal necrotizing enterocolitis (Monographs in neonatology) by Grune & Stratton (Publisher) | |
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Gale Encyclopedia of Medicine: Necrotizing enterocolitis by Caroline A. Helwick (Author) The article is excerpted from Gale Encyclopedia of Medicine. Consult the second edition of this authoritative, comprehensive, in-depth medical guide for information on more than 1,700 medical topics in language accessible to adult laypersons. Presented in a single alphabetical sequence, articles range in length from one or two paragraphs for minor topics, to several pages or more for major topics. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes; precautions; preparation; risks; normal and abnormal results; and much more. This second edition includes more than 200 new entries, 300 updated entries, approximately 650 color... | |
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Necrotizing Enterocolitis (Clinics in Perinatology, Volume 21, Number 2, June 1994) by Barbara J. Stoll MD (Editor), Robert M. Kliegman MD (Editor) June 1994 issue | |
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Necrotizing Enterocolitis (Medical Intelligence Unit) by Brian F. Gilchrist (Editor) The literature on NEC (necrotizing Enterocolitis), especially in the major textbooks, merely recapitulated what had been written in the past; there has been no new guidance. NEC was viewed as a fait accompli; a sometimes-dire disease that was to be confronted only after it reared its perfidious head. This monograph asks the reader to rethink their approach the NEC. Although, there are no compel others to pursue a way to intervene before the die has been cast. Thus, this book is a promissory note and a challenge. |
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One Step at a Time by Jennifer Smith and Bradie Kvinsland (Author), Charlee Glock (Editor), Eric Haugen (Editor) "One Step at a Time" is a book, keepsake and guide for coping with a child's hospitalization. It offers a unique way for a parent to ask the right questions, record important medical information, and express joy, fear and hope during a very difficult time. And most important, it encourages parents to take care of themselves physically, emotionally and spiritually. |
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Probiotics in Pediatric Medicine (Nutrition and Health) by Sonia Michail (Editor), Philip M. Sherman (Editor) Since the turn of the century, many scientists and investigators have diligently designed and performed experiments and trials to prove or disprove the power of probiotics. A great number of probiotic products in various shapes and forms have become available to the consumer and more than ever clinicians are dealing with children and patients that consider the use of probiotics. Probiotics in Pediatric Medicine provides clinicians a tool to understand the current evidence for the role of probiotics in various pediatric disorders related to the gastrointestinal as well as the extra-intestinal tract. This book provides evidence-based up-to-date information from world experts in their fields to help clinicians make decisions regarding the use of probiotics. A list of resources,... |
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The carotid-vertebral space: an 'extended' lateral window to the ventromedial cranial base and lower craniocervical junction.: An article from: Ear, Nose and Throat Journal by Amin B. Kassam (Author), Atul Patel (Author), William Welch (Author), Jeffrey Balzer (Author), Carl Snyderman (Author), Barry Hirsch (Author), Ricardo Carrau (Author) This digital document is an article from Ear, Nose and Throat Journal, published by Thomson Gale on May 1, 2005. The length of the article is 2007 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: The carotid-vertebral space: an 'extended' lateral window to the ventromedial cranial base and lower craniocervical junction. Author: Amin B. Kassam Publication: Ear, Nose and Throat Journal (Magazine/Journal) Date: May 1, 2005 Publisher: Thomson Gale Volume: 84 Issue: 5 Page: 312(4) Distributed by Thomson... |
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