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Identifying the metabolism of a healthy embryo could improve infertility treatment
October 21, 2009Embryos that are most likely to result in a pregnancy are crucial to the success of in vitro fertilization (IVF) but are difficult to identify. Researchers at Yale School of Medicine, led by Emre Seli, M.D., are developing a fast, non-invasive test to help assess embryo viability for IVF.
Seli, associate professor in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale, will present new embryo selection findings at the American Society for Reproductive Medicine (ASRM) meeting held in Atlanta, Georgia from October 17 to 21.
Women undergoing infertility treatment with IVF are hormonally stimulated to produce multiple eggs, which are then fertilized in the lab. In most cases, multiple embryos are generated and cultured. Selecting embryos for implantation is currently highly subjective.
"It's a guessing game that can end in IVF failure or multiple pregnancies," said Seli. "Our goal is to find a way to pinpoint the embryos with the best chance of success, so that we can transfer fewer embryos and cut down on the possibility of multiple pregnancies without reducing the pregnancy rate."
To detect the difference between a viable and non-viable embryo, Seli and his team have studied the metabolomic profile of spent embryo cultures. A metabolomic profile is the unique chemical fingerprint that results from the metabolic activity of embryos in culture. The team previously found that metabolomic profiling could give an instant snapshot of the physiology of a cell. This non-invasive approach may provide a useful adjunct to the current embryo grading systems based on the structure of the embryo and the rate at which the embryo divides.
Building on this groundbreaking finding, Seli and his team have found that a viability score generated by non-invasive assessment of embryo culture media using metabolomics affected pregnancy outcomes in women treated in four different centers in Europe and Australia. This study-performed in collaboration with Molecular Biometrics, Inc. and co-authored by Denny Sakkas, Lucy Botros, Marc Henson and Kevin Judge-will be presented at the ASRM meeting.
"These findings have important implications for the more than 125,000 IVF cycles performed yearly in the United States," said Seli. "The high multiple pregnancy rates associated with IVF have significant public health consequences, such as decreased survival and increased risk of lifelong disability associated with severe prematurity."
Yale University
"It's a guessing game that can end in IVF failure or multiple pregnancies," said Seli. "Our goal is to find a way to pinpoint the embryos with the best chance of success, so that we can transfer fewer embryos and cut down on the possibility of multiple pregnancies without reducing the pregnancy rate."
To detect the difference between a viable and non-viable embryo, Seli and his team have studied the metabolomic profile of spent embryo cultures. A metabolomic profile is the unique chemical fingerprint that results from the metabolic activity of embryos in culture. The team previously found that metabolomic profiling could give an instant snapshot of the physiology of a cell. This non-invasive approach may provide a useful adjunct to the current embryo grading systems based on the structure of the embryo and the rate at which the embryo divides.
Building on this groundbreaking finding, Seli and his team have found that a viability score generated by non-invasive assessment of embryo culture media using metabolomics affected pregnancy outcomes in women treated in four different centers in Europe and Australia. This study-performed in collaboration with Molecular Biometrics, Inc. and co-authored by Denny Sakkas, Lucy Botros, Marc Henson and Kevin Judge-will be presented at the ASRM meeting.
"These findings have important implications for the more than 125,000 IVF cycles performed yearly in the United States," said Seli. "The high multiple pregnancy rates associated with IVF have significant public health consequences, such as decreased survival and increased risk of lifelong disability associated with severe prematurity."
Yale University
Infertility Treatment Current Events and Infertility Treatment News RSSStem cell research puts interstate rivalry on hold
Victoria and New South Wales have put aside their competitive interstate rivalry to collaborate on a stem cell research project, as announced by Innovation Minister Gavin Jennings and NSW Minister for Science and Medical Research, Verity Firth, today.
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Physician-Scientists Seek Solutions to Reproductive Problems Related to Chromosomal Variations
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Study reveals surge in male-factor infertility technique
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First research to show that diabetes damages DNA in men's sperm and may affect fertility
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Sperm created in the laboratory from embryonic stem cells produce viable progeny
Scientists have demonstrated for the first time that embryonic stem (ES) cells cultured in the laboratory can produce sperm with the capacity to produce viable offspring.
Slight increased risk of major birth defects associated with IVF
Babies conceived through in vitro fertilization (IVF), a method of assisted reproduction, have a slightly increased risk of major birth defects, such as heart or muscle and skeletal defects, compared to babies conceived naturally.
EU Enlargement Could Lead To Fertility Tourism From West To East
Fertility tourists could be heading for eastern European countries in the wake of EU enlargement as data revealed today show that parts of the East match the West in terms of the availability and efficacy of assisted reproduction techniques, but cost less. Dr Anders Nyboe Andersen, Head of the Fertility Clinic at the Rigshospitalet at Copenhagen University Hospital, Denmark, told fertility experts that countries such as Slovenia and Hungary are achieving success rates after in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI) that are as good as the best in the West. Presenting preliminary data on ART in Europe*, Dr Nyboe Andersen told the 20th annual conference of the Eu
Preimplantation Genetic Diagnosis (PGD) should be allowed in Germany: study reveals demand for a change in the law
Current legislation on preimplantation genetic diagnosis (PGD) in Germany is out of step with the attitudes of Germans and should be changed, researchers told a news briefing at the 20th annual meeting of the European Society of Human Reproduction and Embryology on Monday 28 June). At present PGD is forbidden in Germany, but in one of the first large study of attitudes to PGD amongst the general population and infertile couples in Germany, the researchers found that the majority of Germans think the technique should be permitted. Dr Ada Borkenhagen, a psychologist and researcher at Charité Berlin, together with colleagues at the Berlin Fertility Centre and the universities of Leipzig
A twist in the tail - Leeds researchers show how sperm wriggle.
In a discovery with far-reaching potential for advances in infertility treatment, scientists at the University of Leeds have identified what makes sperm wriggle and swim. The answer lies in a protein called dynein. The scientists have taken the first photographs of individual molecules of dynein, also found in lungs, the nervous system and elsewhere in the human body. In an article in this week's Nature, the researchers explain how the protein creates movement. Project leader Dr Peter Knight said: "Dynein molecules are attached to tiny tubes within the sperm tail, and as the molecules change shape, they make the tubes slide back and forth causing the sperm's tail to wriggle. We call thes
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