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Classifying molar pregnancy
October 21, 2009Baltimore, MD - Researchers from The Johns Hopkins Medical Institutions have used short tandem repeat (STR) genotyping and p57 immunohistochemistry to distinguish hydatidiform moles. The related report by Murphy et al "Molecular Genotyping of Hydatidiform Moles: Analytic Validation of a Multiplex Short Tandem Repeat (STR) Assay," appears in the November 2009 issue of The Journal of Molecular Diagnostics.
Molar pregnancy is an abnormal form of pregnancy in which a fertilized but non-viable egg implants in the uterus, resulting in a hydatidiform mole. Hydatidiform moles, which occur in one in every 1000 pregnancies in the United States, increase the risk of persistent gestational trophoblastic disease (GTD) and choriocarcinoma, a malignant, rapidly-growing, and metastatic form of cancer. Molar pregnancies can have either partial or complete hydatidiform moles. Complete hydatidiform moles (CHMs) arise when an empty egg with no nucleus is fertilized by a normal sperm, and partial hydatidiform moles (PHMs) arise from a normal egg fertilized by two sperm.
CHMs, PHMs, and non-molar specimens (NMs) have different risks for persistent GTD, and thus differentiation is important for clinical treatment of patients. Morphological diagnosis results in high inter- and intra-observer variability; therefore, Murphy et al explore using genetic features to differentiate CHMs, PHMs, and NMs. They found that STR genotyping and p57 immunohistochemistry, by identifying the parental source of particular alleles, can distinguish CHMs, PHMs, and NMs and have developed an algorithm for the interpretation of STR data.
Dr. Murphy and her colleague Dr Brigitte Ronnett "have applied this algorithm in routine practice to ensure accurate diagnosis of hydatidiform moles. In doing so, they have determined that the genetics of molar specimens can be more complicated than traditionally thought." Drs. Murphy and Ronnett are now working to "discover additional risk factors for GTD, in order to identify women who may require chemotherapy."
American Journal of Pathology
Dr. Murphy and her colleague Dr Brigitte Ronnett "have applied this algorithm in routine practice to ensure accurate diagnosis of hydatidiform moles. In doing so, they have determined that the genetics of molar specimens can be more complicated than traditionally thought." Drs. Murphy and Ronnett are now working to "discover additional risk factors for GTD, in order to identify women who may require chemotherapy."
American Journal of Pathology
Women With Rare Twin-pregnancy Complication Have 40% Chance Of Delivering One Baby (p 2165)
Authors of a research letter in this week's issue of THE LANCET provide evidence to suggest that women with a rare twin-pregnancy disorder are at no more increased risk of malignant disease than women with the disorder who choose to have their pregnancy terminated. Hydatidiform moles are a pregnancy complication where the fetus fails to develop; instead a tumour forms which may become malignant. Hydatidiform moles arise in about one in 1000 to three in 1000 pregnancies; around 16% become malignant, requiring treatment with chemotherapy. For this reason, hydatidiform moles are removed from the womb when they are diagnosed. Twin pregnancies with one healthy fetus and one hydatidiform mole are
More Hydatidiform Current Events and Hydatidiform News Articles
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My Molar Pregnancy: A Collection of Personal Stories From Diagnosis Through Recovery by Jennifer Wood (Editor) Molar pregnancies occur in 1 in 1,500 pregnancies. They are so rare that many doctors can go their entire careers without treating one case. For a woman with this diagnosis, it is a roller coaster of shock, grief, and fear. In most cases she has miscarried or must end a pregnancy and is mourning the loss of a baby. Now she is now faced with a new and unexpected fear: cancer. After her own molar pregnancy in 2001, Jennifer Wood created MyMolarPregnancy.com as a resource and support group for women with molar pregnancies. Since then, countless women have found help and shared their own stories to help others. This book contains nearly three dozen such stories from diagnosis through treatment and recovery. It also includes descriptions of molar pregnancy and choriocarcinoma and the... |
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Gale Encyclopedia of Medicine: Hydatidiform mole by Carol A. Turkington (Author) The article is excerpted from Gale Encyclopedia of Medicine. Consult the second edition of this authoritative, comprehensive, in-depth medical guide for information on more than 1,700 medical topics in language accessible to adult laypersons. Presented in a single alphabetical sequence, articles range in length from one or two paragraphs for minor topics, to several pages or more for major topics. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes; precautions; preparation; risks; normal and abnormal results; and much more. This second edition includes more than 200 new entries, 300 updated entries, approximately 650 color... | |
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Trophoblastic Growths. Aclinical, hormonal and histopathalogic study of hydatidiform mole and chorionepithelioma, etc. [With illustrations.] by Jan Smalbraak (Author) | |
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Hydatidiform Mole: An entry from Gale's Gale Encyclopedia of Medicine, 3rd ed. by Carol Turkington (Author) This digital document is an article from Gale Encyclopedia of Medicine, 3rd ed., brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses. The length of the article is 1098 words. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. The third edition of this authoritative, comprehensive, in-depth medical guide features information on medical topics in language accessible to adult laypersons. Disease/disorder articles typically cover definition; description; causes and symptoms; diagnosis; treatments; prevention; and more. Test/treatment articles typically cover definition; purposes;... | |
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Tumors of the Female Sex Organs Part 1 - Hydatidiform mole and choriocarcinoma by Arthur T Hertig (Author), Hazel Gore (Author) Tumors of the Female Sex Organs -- Armed Forces Institute of Pathology. Part 1 - Hydatidiform mole and choriocarcinoma |
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Tumors of the female sex organs (Atlas of tumor pathology) : Part 1: Hydatidiform Mole and Choriocarcinoma; by Arthur Tremain Hertig (Author) | |
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The diagnosis of hydatidiform mole, malignant hydatidiform mole and choriocarcinoma with special reference to the diagnostic value of pelvic arteriography, by Ulf Soren Mendelsson Borell (Author) | |
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The Genetics of Familial Hydatidiform Moles: The Identification of the First Maternal Effect Gene in Humans by Sharlene Murdoch (Author) Hydatidiform Moles are an abnormal pregnancy in which no foetus forms. Instead, the placental villi proliferate as fluid filled sacs with tumourigenic potential. This is a relatively common disorder occurring in 1 in 1500 pregnancies in North America, and even higher in other populations. In certain women hydatidiform moles have been found to recur, and in even rarer cases they recur in multiple women in the same family. These recurrent cases have allowed identification of a genetic defect causing these moles.Mutations in NLPR7, a gene implicated in the innate immune response, were originally identified in four families with recurrent moles, pinpointing it as the gene responsible for this disorder.This work introduces the history of molar research, describes the identification of the... |
![Increased DNA damage in patients with complete hydatidiform mole [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis]](http://ecx.images-amazon.com/images/I/51VRJGWFK9L._SL160_.jpg) |
Increased DNA damage in patients with complete hydatidiform mole [An article from: Mut.Res.-Genetic Toxicology and Environmental Mutagenesis] by M. Harma (Author), A. Kocyigit (Author), O. Erel (Author) This digital document is a journal article from Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, published by Elsevier in 2005. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser. Description: The pathologic mechanisms underlying the gestational trophoblastic diseases are largely unexplored, but are thought to involve oxidative damage to the maternal vasculature and also to the placenta. In this study we have assessed the plasma levels of total antioxidant response (TAR) and the levels of endogenous DNA damage - determined by the comet assay - in peripheral blood lymphocytes from 13 women with complete hydatidiform mole (CHM) and compared these with those of 12... |
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Congenital malformations, Hydatidiform Moles, and Stillbirths in the Republic of Vietnam 1960-1969. by et al. Robert T. Cutting (Author) |
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