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Lifestyle changes remain important in fighting peripheral arterial disease
October 22, 2009Not enough evidence yet to support minimally invasive treatment in those with blocked leg artery and showing no symptoms, say researchers in Journal of Vascular and Interventional Radiology
FAIRFAX, Va.-Modifying the risk of peripheral arterial disease (or PAD)-with healthy lifestyle changes-remains vital to one's health, note researchers in a recent issue of the Journal of Vascular and Interventional Radiology. And while PAD can progress and worsen over time, there is not enough evidence yet to advocate minimally invasive treatment in patients who have had a narrowing or blockage of a leg artery but showing no signs or symptoms of the disease, say Irish researchers in a retrospective study of more than 900 individuals.
"In the early stages of PAD, many patients will have no symptoms at all and often will go undiagnosed," noted Aoife Keeling, an interventional radiologist at Northwestern Hospital in Chicago, Ill. She indicated that the prevalence or frequency of asymptomatic PAD is likely underestimated; however, researchers studied whether minimally invasive treatments-such as angioplasty and/or stenting-should be offered to asymptomatic PAD patients. "While this study is useful in examining the possibility of treating PAD earlier, additional research into the factors that cause PAD progression and the rate of progression-along with methods to slow the disease-need to be conducted," said Keeling. "Prevention of PAD progression is vital and can be achieved with risk factor modification, for example, if individuals stop smoking, watch their diets, lower their cholesterol and have their blood pressure monitored," she noted.
PAD (or "hardening of the arteries" particularly in one's legs) affects an estimated 10 million people in the United States. PAD occurs when plaque accumulates in arteries that supply blood to areas of the body other than the heart and brain. Since plaque blocks the leg arteries first, PAD is considered a red flag for several life-threatening vascular diseases, such as heart attack (the number one killer in this country) and stroke; it can also result in the loss of limb(s). PAD causes a range of symptoms, from no symptoms to pain in the legs while walking (intermittent claudication) to its most severe form that results in pain in the feet/legs at rest that can progress to ulcers (sores/wounds on the feet and toes) and eventual gangrene (black discoloration of the toes or feet; also called critical limb ischemia). The disease's progression can result in limb loss and even in death.
In the study, 918 patients had leg angiograms (an X-ray exam to diagnose arterial blockage and other problems). Of these, 122 patients (54 percent male, average age 70 years) had an arterial narrowing (50 percent) or blockage without any corresponding leg symptoms, said Keeling. These patients were followed over a maximum of nine years to determine if they developed any symptoms and to see if they required any treatment for their PAD in the form of angioplasty, stenting, surgical bypass or amputation. One-third of the 122 patients developed symptoms of pain or ulceration and almost half of these then required treatment. Overall, only 13.9 percent of the initial group required treatment, so even though PAD progressed over time, the researchers did not believe they had enough evidence to advocate early minimally invasive treatment of PAD in patients who had no initial symptoms, said Keeling. The fact that most of the 122 patients remained asymptomatic may be related to the intense risk factor modification they underwent or other factors as yet unidentified, said Keeling. "We know that many patients have blockages in their leg arteries but may not develop symptoms. We don't know yet what causes symptoms to develop in some but not in others. We are continuing our research in this area," she added.
Research shows that the highest risk populations for PAD include seniors (12-20 percent develop the disease), African-Americans (twice as likely to develop clogged leg arteries) and diabetics (one in three who are over the age of 50 develop PAD). In many cases, PAD can be treated with medication (such as blood thinners or drugs that dilate an affected artery), lifestyle changes (such as smoking cessation), diet and a structured exercise program. With early detection, patients could see an interventional radiologist when intervention is most effective and less invasive treatments are an option. If needed, interventional radiologists can perform minimally invasive angioplasty and/or stenting to open a blocked artery in the leg and restore blood flow.
Society of Interventional Radiology
PAD (or "hardening of the arteries" particularly in one's legs) affects an estimated 10 million people in the United States. PAD occurs when plaque accumulates in arteries that supply blood to areas of the body other than the heart and brain. Since plaque blocks the leg arteries first, PAD is considered a red flag for several life-threatening vascular diseases, such as heart attack (the number one killer in this country) and stroke; it can also result in the loss of limb(s). PAD causes a range of symptoms, from no symptoms to pain in the legs while walking (intermittent claudication) to its most severe form that results in pain in the feet/legs at rest that can progress to ulcers (sores/wounds on the feet and toes) and eventual gangrene (black discoloration of the toes or feet; also called critical limb ischemia). The disease's progression can result in limb loss and even in death.
In the study, 918 patients had leg angiograms (an X-ray exam to diagnose arterial blockage and other problems). Of these, 122 patients (54 percent male, average age 70 years) had an arterial narrowing (50 percent) or blockage without any corresponding leg symptoms, said Keeling. These patients were followed over a maximum of nine years to determine if they developed any symptoms and to see if they required any treatment for their PAD in the form of angioplasty, stenting, surgical bypass or amputation. One-third of the 122 patients developed symptoms of pain or ulceration and almost half of these then required treatment. Overall, only 13.9 percent of the initial group required treatment, so even though PAD progressed over time, the researchers did not believe they had enough evidence to advocate early minimally invasive treatment of PAD in patients who had no initial symptoms, said Keeling. The fact that most of the 122 patients remained asymptomatic may be related to the intense risk factor modification they underwent or other factors as yet unidentified, said Keeling. "We know that many patients have blockages in their leg arteries but may not develop symptoms. We don't know yet what causes symptoms to develop in some but not in others. We are continuing our research in this area," she added.
Research shows that the highest risk populations for PAD include seniors (12-20 percent develop the disease), African-Americans (twice as likely to develop clogged leg arteries) and diabetics (one in three who are over the age of 50 develop PAD). In many cases, PAD can be treated with medication (such as blood thinners or drugs that dilate an affected artery), lifestyle changes (such as smoking cessation), diet and a structured exercise program. With early detection, patients could see an interventional radiologist when intervention is most effective and less invasive treatments are an option. If needed, interventional radiologists can perform minimally invasive angioplasty and/or stenting to open a blocked artery in the leg and restore blood flow.
Society of Interventional Radiology
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Promising 3-year data: Saving limbs with drug-eluting stents
Attempts to treat critical limb ischemia in peripheral arterial disease (PAD) patients with below-the-knee angioplasty are still thwarted by restenosis (the re-narrowing of the artery at the site of angioplasty or stenting), the need for repeat treatments and the continued progression of atherosclerotic disease, leading to tissue death (gangrene) and amputation.
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Interventional radiologists are fitting together the puzzle pieces of how to use stem cells to create new or more blood vessels to treat peripheral arterial disease (PAD) in those individuals with extensively narrowed or clogged arteries.
Simple test helps predict heart attack risk
The use of common and readily available screening tests-like the ankle brachial index (ABI)-along with traditional risk scoring systems-such as the Framingham Risk Score-has the potential to prevent devastating heart attacks in thousands of individuals who are not originally thought to be at high risk (according to Framingham alone), say researchers at the Society of Interventional Radiology's 34th Annual Scientific Meeting.
Seaweed and fireflies brew may guide stem cell treatment for peripheral artery disease
An unlikely brew of seaweed and glow-in-the-dark biochemical agents may hold the key to the safe use of transplanted stem cells to treat patients with severe peripheral arterial disease (PAD), according to a team of veterinarians, basic scientists and interventional radiologists at Johns Hopkins.
For old or young dialysis patients, AV fistulas remain pure gold
A new study shows that for those individuals with chronic kidney disease, it doesn't matter if you're young or old: arteriovenous (AV) fistulas remain the gold standard for maintaining access to one's circulatory system to provide life-sustaining dialysis.
Low-dose aspirin does not appear to reduce risk of CV events in patients with diabetes
Low-dose aspirin as primary prevention did not appear to significantly reduce the risk of a combined end point of coronary, cerebrovascular and peripheral vascular events in patients with type 2 diabetes, according to a new study in JAMA.
Aspirin does not prevent heart attacks in patients with diabetes
Taking regular aspirin and antioxidant supplements does not prevent heart attacks even in high risk groups with diabetes and asymptomatic arterial disease, and aspirin should only be given to patients with established heart disease, stroke or limb arterial disease.
Sexual dissatisfaction in postmenopausal women not linked to cardiovascular disease
Although sexual dysfunction in some men is predictive of cardiovascular disease, this association has never been examined in women.
Decreased sexual satisfaction is not associated with cardiovascular disease in postmenopausal women
Researchers from Boston University School of Medicine (BUSM) and Boston Medical Center (BMC) and collaborators nationwide have found that decreased sexual satisfaction in postmenopausal women, is not clearly associated with cardiovascular disease.
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