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Cholesterol-lowering medicines may be effective against cancer
October 28, 2009Statins lower cholesterol by blocking certain enzymes involved in our metabolism. However, they have also been shown to affect other important lipids in the body, such as the lipids that help proteins to attach to the cell membrane (known as lipid modification). Because many of the proteins that are lipid-modified cause cancer, there are now hopes that it will be possible to use statins in the treatment of cancer.
Ideal test subject
It is, however, very difficult to study the side-effects of statins in mammals. As a first step, Marc Pilon, researcher at the Department of Cell and Molecular Biology at the University of Gothenburg, has teamed up with Swedish and international colleagues to carry out studies on the nematode C. elegans. This nematode, which is made up of just a thousand or so cells, does not produce cholesterol and is therefore an ideal test subject.
Can treat diabetes
The Gothenburg researchers' studies show that statins can have a dramatic inhibitory effect on growth and development. As the researchers managed to identify the enzyme involved, they can also explain how the effect arises at molecular level.
"Our results support the idea that statins can be used in more ways than just to lower cholesterol," says Pilon. "Not least that they can prevent the growth of cancer cells caused by lipid-modified proteins, but also that they can be effective in the treatment of diabetes and neurological disorders such as Parkinson's."
The article Statins Inhibit Protein Lipidation and Induce the Unfolded Protein Response in the Non-Sterol Producing Nematode C. elegans, published in the journal PNAS, is the result of a research partnership between the University of Gothenburg, Chalmers University of Technology and the University of Southern Denmark.
University of Gothenburg, Sweden
Can treat diabetes
The Gothenburg researchers' studies show that statins can have a dramatic inhibitory effect on growth and development. As the researchers managed to identify the enzyme involved, they can also explain how the effect arises at molecular level.
"Our results support the idea that statins can be used in more ways than just to lower cholesterol," says Pilon. "Not least that they can prevent the growth of cancer cells caused by lipid-modified proteins, but also that they can be effective in the treatment of diabetes and neurological disorders such as Parkinson's."
The article Statins Inhibit Protein Lipidation and Induce the Unfolded Protein Response in the Non-Sterol Producing Nematode C. elegans, published in the journal PNAS, is the result of a research partnership between the University of Gothenburg, Chalmers University of Technology and the University of Southern Denmark.
University of Gothenburg, Sweden
Lower Cholesterol Current Events and Lower Cholesterol News RSSWet ethanol production process yields more ethanol and more co-products
Using a wet ethanol production method that begins by soaking corn kernels rather than grinding them, results in more gallons of ethanol and more usable co-products, giving ethanol producers a bigger bang for their buck - by about 20 percent.
Use of statins favors the wealthy, creating new social disparities in cholesterol
Since the introduction of statins to treat high cholesterol, the decline in lipid levels experienced by the wealthy has been double that experienced by the poor.
Pre-hospital organization: The first links in the chain of survival for heart attack patients
Mortality rate following a heart attack has fallen by more than 50% in Europe over the past 25 years. However, because only minor advances in the medical treatment of AMI are expected over the next decade, it is through organisational changes in the pre-hospital phase that mortality rate will continue this decline to below 5%.
Weight-loss surgery can break a family's cycle of obesity
Adolescent and young children of obese mothers who underwent weight-loss surgery prior to pregnancy have been found to have a lower prevalence of obesity and significantly improved cardio-metabolic markers when compared to siblings born before the same obese mothers had weight-loss surgery.
Nuisance or nutrient? Kudzu shows promise as a dietary supplement
Kudzu, the nuisance vine that has overgrown almost 10 million acres in the southeastern United States, may sprout into a dietary supplement.
UCLA scientists uncover immune system's role in bone loss
Got high cholesterol? You might want to consider a bone density test. A new UCLA study sheds light on the link between high cholesterol and osteoporosis and identifies a new way that the body's immune cells play a role in bone loss.
New tool finds best heart disease and stroke treatments for patients with diabetes
Researchers from North Carolina State University and Mayo Clinic have developed a computer model that medical doctors can use to determine the best time to begin using statin therapy in diabetes patients to help prevent heart disease and stroke.
Statin therapy ineffective in breast cancer prevention
Laboratory work in animals showed limited activity when statins were given to prevent breast cancer, according to a report in the February issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.
First comprehensive paper on statins' adverse effects released
A paper co-authored by Beatrice Golomb, MD, PhD, associate professor of medicine at the University of California, San Diego School of Medicine and director of UC San Diego's Statin Study group cites nearly 900 studies on the adverse effects of HMG-CoA reductase inhibitors (statins), a class of drugs widely used to treat high cholesterol.
Mayo Clinic study finds risk of sudden cardiac death highest early after attack
People who survive a heart attack face the greatest risk of dying from sudden cardiac death (SCD) during the first month after leaving the hospital, according to a long-term community study by Mayo Clinic researchers of nearly 3,000 heart attack survivors.
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Cholesterol Down: Ten Simple Steps to Lower Your Cholesterol in Four Weeks--Without Prescription Drugs by Janet Brill (Author) Take Control of Your Cholesterol— Without Drugs If you are one of the nearly 100 million Americans struggling with high cholesterol, then Dr. Janet Brill offers you a revolutionary new plan for taking control of your health—without the risks of statin drugs. With Dr. Brill’s breakthrough Cholesterol Down Plan, you simply add nine “miracle foods” to your regular diet and thirty minutes of walking to your daily routine. That’s all. This straightforward and easy-to-follow program can lower your LDL (“bad”) cholesterol by as much as 47 percent in just four weeks. Cholesterol Down explains Dr. Brill’s ten-point plan as well as the science behind it. You’ll learn how each miracle food affects LDL cholesterol and how the foods work together for maximum effect,... |
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50 Ways to Lower Cholesterol by Mary McGowan (Author) Because diet, weight, exercise, and genetics determine cholesterol levels, the treatment of a cholesterol disorder requires a multifaceted approach. 50 Ways to Lower Your Cholesterol provides you with a proven plan to lower cholesterol. Here, the author delivers sound advice, 50 workable solutions, explanations of both "good" and "bad" cholesterol, and the latest information on key treatments--including LDL-apheresis, superstatins, and cholesterol ester transfer protein inhibitors--medication, and supplements. |
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Eating for Lower Cholesterol: A Balanced Approach to Heart Health with Recipes Everyone Will Love by Catherine Jones (Author), Elaine Trujillo MS RD CNSD MS RD CNSD (Contributor) Eating for lower cholesterol has never been easier, or tastier. High cholesterol is directly associated with heart disease. New national guidelines for healthy cholesterol levels, recently revised to be more stringent, mean millions of Americans need to bring their levels down. While doctors fill out millions of prescriptions for cholesterol-lowering drugs, diet remains a proven, supremely effective way to reduce cholesterol. Now, professional cookbook author and health-conscious chef, Catherine Jones, and one of the nation’s leading nutritionists, Elaine B. Trujillo, offer a wealth of cutting-edge information along with a collection of delicious recipes to help lower your cholesterol levels. Key features of this authoritative, information-packed book include: • An... |
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BMV Quantum Subliminal CD Lower Cholesterol: Low Cholesterol Mind Program (Ultrasonic Subliminal Series) Program your subconscious mind to lower cholesterol levels. Create life-changing results using state-of-the-art subliminal and brainwave entrainment technologies. Tune your brainwaves to specific frequencies by listening to this CD! Program your subconscious mind for positive lasting results, created by a Certified Hypnotherapist and NLP Practitioner (Neuro-Linguistic Programming). Silent affirmations, inaudible hypnotic suggestions and thousands of powerful subliminal messages program your subconscious mind for positive results. The first 3 tracks have an ocean background. The Silent Ultrasonic Track 4 is completely silent with no sound at all! BMV exclusive Quantum Subliminal Matrix Technology sets a new standard for the subliminal industry! BMV has merged existing subliminal... |
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