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Exercise is good medicine for lymphoma patients
October 28, 2009A healthy dose of exercise is good medicine, even for lymphoma patients receiving chemotherapy, University of Alberta researchers have found.
The Healthy Exercise for Lymphoma Patients (HELP) trial, a three-year study led by Kerry Courneya, Canada Research Chair in physical activity and cancer in the Faculty of Physical Education and Recreation, found that a regimen of aerobic exercise training produced significant improvements in physical functioning and overall quality of life benefits in patients with lymphoma.
Researchers recruited 122 patients with Hodgkin's and non-Hodgkin's lymphoma, then stratified participants by disease type and treatment status; whether they were undergoing chemotherapy at the time or receiving no treatments. Participants were randomly assigned to an exercise program designed to maximize cardiovascular fitness or to usual care, which did not include an exercise component.
Exercisers trained three times a week for 12 weeks and were encouraged to stay the course with behavioural support techniques that included perks like free parking, a well-equipped gym, flexible exercise schedules, variation in exercises, follow-up phone calls reminders and positive reinforcement by staff.
Lymphoma patients who received the exercise intervention reported significantly improved physical functioning, overall quality of life, less fatigue, increased happiness, less depression and an improvement in lean body mass. Cardiovascular fitness in the exercise group improved by over 20 per cent. The group receiving chemotherapy benefited as much as the group that was off treatments.
Perhaps most importantly, says Courneya, was that the vigorous intensity exercise program did not interfere with lymphoma patients' ability to complete their chemotherapy treatments or benefit from the treatments. He found that 46.4 per cent of patients in the exercise group had a complete response to their treatment (no evidence of disease) compared to only 30.8 per cent in the usual care group. Courneya cautions that the trial was not designed to look at this issue, but it at least suggests that lymphoma patients can achieve important health and quality of life benefits from exercise during treatment without worrying about compromising their treatment outcomes.
University of Alberta
Exercisers trained three times a week for 12 weeks and were encouraged to stay the course with behavioural support techniques that included perks like free parking, a well-equipped gym, flexible exercise schedules, variation in exercises, follow-up phone calls reminders and positive reinforcement by staff.
Lymphoma patients who received the exercise intervention reported significantly improved physical functioning, overall quality of life, less fatigue, increased happiness, less depression and an improvement in lean body mass. Cardiovascular fitness in the exercise group improved by over 20 per cent. The group receiving chemotherapy benefited as much as the group that was off treatments.
Perhaps most importantly, says Courneya, was that the vigorous intensity exercise program did not interfere with lymphoma patients' ability to complete their chemotherapy treatments or benefit from the treatments. He found that 46.4 per cent of patients in the exercise group had a complete response to their treatment (no evidence of disease) compared to only 30.8 per cent in the usual care group. Courneya cautions that the trial was not designed to look at this issue, but it at least suggests that lymphoma patients can achieve important health and quality of life benefits from exercise during treatment without worrying about compromising their treatment outcomes.
University of Alberta
Lymphoma Current Events and Lymphoma News RSSDrugs to treat anemia in cancer patients linked to thromboembolism
Medications frequently given to cancer patients to reduce their risk of anemia are associated with an increased risk of deep vein thrombosis or pulmonary embolism, according to new research led by Dawn Hershman, M.D, M.S., co-director of the breast cancer program at the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center.
Researchers find new way to attack inflammation in Graves' eye disease
A small group of patients with severe Graves' eye disease experienced rapid improvement of their symptoms - and improved vision - following treatment with the drug rituximab.
Approved lymphoma drug shows promise in early tests against bone cancer
A drug already approved for the treatment of lymphoma may also slow the growth of the most deadly bone cancer in children and teens, according to an early-stage study published online today in the International Journal of Cancer.
Immunotherapy demonstrates long-term success in treating lymphoma
Targeted immunotherapy has been an attractive new therapeutic area for a number of cancers because it has the potential to destroy tumor cells without damaging surrounding normal tissue. New study results demonstrate high success rates using specialized white blood cells to prevent or treat lymphoma associated with the Epstein-Barr virus (EBV-lymphoma) in patients who have received a hematopoietic stem cell transplant (HSCT).
Childhood cancer survivors experience suicidal thoughts decades after diagnosis
Adult survivors of childhood cancer have an increased risk for suicidal thoughts, even decades after their cancer treatments ended, according to a study led by Dana-Farber Cancer Institute scientists.
New therapy for vasculitis will help patients avoid infertility and cancer
Researchers have identified that Rituxan, a drug previously approved for the treatment of non-Hodgkin's B cell lymphoma and rheumatoid arthritis, can treat severe ANCA-associated vasculitis as effectively as cyclophosphamide, the current standard therapy.
Studying cancer in pet dogs to find new treatments for human patients
A team of scientists at the National Cancer Institute (NCI) in Bethesda, USA, says that studying pet dogs with cancer could yield valuable information on how to diagnose and treat human cancers.
Scientists identify genetic cause of previously undefined primary immune deficiency disease
Researchers at the National Institutes of Health have identified a genetic mutation that accounts for a perplexing condition found in people with an inherited immunodeficiency.
Certain cancers more common among HIV patients than non-HIV patients
Researchers at UT Southwestern Medical Center have found that non-AIDS-defining malignancies such as anal and lung cancer have become more prevalent among HIV-infected patients than non-HIV patients since the introduction of anti-retroviral therapies in the mid-1990s.
Identification of highly radiosensitive patients may lead to side effect-free radiotherapy
An international group of scientists has taken the first step on the road to targeting radiotherapy dosage to individual patients by means of their genetic characteristics.
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