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MicroRNA-mediated metastasis suppression
October 29, 2009Metastases are responsible for over 90% of cancer deaths. In the upcoming issue of G&D, Dr. Robert Weinberg (MIT) and colleagues lend molecular insight into how microRNAs suppress tumor metastasis.
Scott Valastyan, lead author on the study, describes it as presenting "detailed mechanistic insight regarding the process of tumor metastasis, and identifies several key regulators of this process that might prove to be interesting diagnostic and/or therapeutic targets in breast cancer."
Dr. Weinberg's group previously showed that the human microRNA, miR-31, suppresses breast cancer metastasis and that its expression is associated with patient outcome. miR-31 regulates the expression of almost 200 genes. However, in this new paper, the authors identify that re-introduction of three miR-31 targets is sufficient to completely reverse miR-31's influence on metastasis.
The researchers characterized both the individual and overlapping contributions that each of these three miR-31 effectors makes to the metastatic process. While three distinct steps are affected by this cohort of miR-31 targets (namely local invasion, early post-intravasation events and metastatic colonization), of particular interest was the finding that two of the three effectors regulate metastatic colonization - the final and rate-limiting step of metastasis.
Scott Valastyan emphasizes that "Our finding that miR-31, integrin-alpha5, and radixin affect the process of metastatic colonization may be of particular interest in light of the fact that colonization efficiency is strongly associated with patient survival outcome in many human tumor types - including breast cancer".
Cold Spring Harbor Laboratory
The researchers characterized both the individual and overlapping contributions that each of these three miR-31 effectors makes to the metastatic process. While three distinct steps are affected by this cohort of miR-31 targets (namely local invasion, early post-intravasation events and metastatic colonization), of particular interest was the finding that two of the three effectors regulate metastatic colonization - the final and rate-limiting step of metastasis.
Scott Valastyan emphasizes that "Our finding that miR-31, integrin-alpha5, and radixin affect the process of metastatic colonization may be of particular interest in light of the fact that colonization efficiency is strongly associated with patient survival outcome in many human tumor types - including breast cancer".
Cold Spring Harbor Laboratory
Metastasis Current Events and Metastasis News RSSCommon pain relief medication may encourage cancer growth
Although morphine has been the gold-standard treatment for postoperative and chronic cancer pain for two centuries, a growing body of evidence is showing that opiate-based painkillers can stimulate the growth and spread of cancer cells.
UCLA researchers create 'fly paper' to capture circulating cancer cells
Just as fly paper captures insects, an innovative new device with nano-sized features developed by researchers at UCLA is able to grab cancer cells in the blood that have broken off from a tumor.
Unexplained liver hemorrhage after metastasis radiofrequency ablation
Colorectal carcinoma is one of the most common cancers in the world. Approximately one in four of these patients have metastases at diagnosis, liver being the most common site involved.
Experimental agent reduces breast cancer metastasis to bone
Researchers have reduced breast cancer metastasis to bone using an experimental agent to inhibit ROCK, a protein that was found to be over-expressed in metastatic breast cancer.
Study of concurrent radiotherapy, chemotherapy shows promise in small cell lung cancer
Treating limited stage small cell lung cancer(LSCL) with a combination of accelerated high-dose radiotherapy and chemotherapy has shown encouraging results.
Is short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis?
Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer.
A case of post-gastrectomy acute pancreatitis
Gastrectomy is commonly performed for both benign and malignant lesions. Although the incidence of post-gastrectomy acute pancreatitis (PGAP) is low compared to other well-recognized post-operative complications, it has been reported to be associated with a high mortality rate.
Bioluminescence imaging used for eye cancer detection
At the moment, doctors rely on biopsy analysis to determine the progression of eye cancer. However, researchers now believe that a new technology, bioluminescence imaging (BLI), will allow doctors to detect tumors earlier and quickly choose a method of treatment that doesn't necessarily involve eye surgery.
KEAP1 Keeps major cancer-promoting protein at bay
A tumor-suppressing protein snatches up an important cancer-promoting enzyme and tags it with molecules that condemn it to destruction, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports this week in the journal Molecular Cell.
NEDD9 Protein Supports Growth of Aggressive Breast Cancer
Researchers at Fox Chase Cancer Center have demonstrated that a protein called NEDD9 may be required for some of the most aggressive forms of breast cancer to grow. Their findings, based on the study of a mouse model of breast cancer, are presented in a recent issue of Cancer Research, available on-line now.
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Xenakis: Metastasis; Pithoprakta; Eonta Iannis Xenakis (Composer), Maurice Le Roux (Composer), Ensemble Instrumental de Musique Contemporaine de Paris (Composer), ORTF National Orchestra (Composer), Yuji Takahashi (Composer), G. Moisan (Composer), J. Toulon (Composer), M. Chapellier (Composer), L. Longo (Composer), Pierre Thibaud (Composer) |
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Cancer Metastasis: Experimental Approaches, Volume 29 (Laboratory Techniques in Biochemistry and Molecular Biology) by D. Rusciano (Author), M.M. Burger (Author), D.R. Welch (Editor) The book describes most of the methods that are currently used in metastasis research. Both in vivo and in vitro protocols are illustrated, so that the metastatic process can be either analysed as a whole, or single events addressed separately. Each method is described in the frame of the metastatic process, therefore its significance and its limitations in the context of metastasis are always taken into account. Whenever possible, several alternative procedures are reported per each experimental issue, so that the researcher can choose the one that better suits her/his needs and possibilities. During the past 30 years a big effort has been made to elucidate the molecular mechanisms of cancer metastatis, the leading cause of death for cancer patients. A considerable number of... |
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Metastasis Arturo Tamayo Orchestre Philharmonique du Luxembourg (Primary Contributor) |
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Quick FACTS Bone Metastasis (Quickfacts) by American Cancer Society (Author) A staggering 5.8 million males and 5 million females worldwide are diagnosed with cancer each year. Approximately half of all cancer cases metastasize, contributing to the leading cause of cancer pain. This book emphasizes that every person's cancer is unique, and every person has the right to be well-informed and to be the decision-maker in planning treatment to offer the best possible quality of life. Each book in the "QuickFACTS" series is both comprehensive and a quick read, with highlighted cover tabs for quick reference of specific topics. It covers everything from risk factors to living well after cancer treatment. It provides critical questions to ask the healthcare team. It educates and empowers patients right from the start. It is completely updated with the latest patient... |
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Brain Metastasis: A Multidisciplinary Approach by Lawrence R., M.D. Kleinberg (Editor) New therapies and treatments targeted at brain metastasis are rapidly resulting in improved survival and quality of life for patients with this condition. "Brain Metastasis: A Multidisciplinary Approach" conveys vital information about management strategies, outcomes, and techniques to enable oncologists to provide a full range of appropriate care and counseling to patients with metastatic spread to the brain.Faithful to its title, this text espouses a truly multidisciplinary approach, integrating information from the fields of oncology, neurosurgery, radiation oncology, and neurology. Experts in each specialty have gathered that information which is most important for all physicians caring for patients with brain metastasis."Brain Metastasis" includes complete discussions for all... |
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2006 ANNUAL MEETING A.H.P.B.A DVD 09 AMERICAN HEPATO-PANCREATO-BILIARY ASSOCIATION/2006 Hepatology GENERAL POSTER SESSION: . The impact of margins on outcome following hepatic resection for colorrectal metastasis - Dr. Rowan Parks (UK) . IIC-Acetate in superior to 18F-Fluoroderyglucose (FDG) positron emisson tomography (PET) in evaluating patients with hepatocellular carcinoma - results of a pilot trial - Dr. C. Wright Pinson (USA) . Effect of extending-4 treatment in minimal islet mass transplant model in streptozotocin-induced diabetic mice - Dr. Davin Eckhoff (USA) . Clinical and economic validation of the international study group of pancreatic fistula (ISGPF) classification scheme - Dr. Claudio Bassi (Italy) GENERAL POSTER SESSION: . Extent of lymph node dissection and staging for extrahepatic cholangiocarcinomas -... |
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Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response (Cancer Growth and Progression) by Hans E. Kaiser (Author), Hans E. Kaiser (Editor), Aejaz Nasir (Editor) The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monogaph presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It would be of particular interest to members of the cancer research community, especially those who are actively involved in the study of basic and translational aspects of human cancer. Specifically, this volume includes authentic subject reviews by leading experts on the following aspects: Control of tumor cell motility Role of tumor-cell adhesion and migration in organ-selective metastasis-formation Tumor heterogeneity in relation to invasion and metastasis and its... |
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Metastasi Cursed Land Entertainment. |
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Metastasis Effacer (Primary Contributor) |
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Lung Cancer Metastasis: Novel Biological Mechanisms and Impact on Clinical Practice by Venkateshwar Keshamouni (Editor), Douglas Arenberg (Editor), Gregory Kalemkerian (Editor) Lung cancer is the leading cause of cancer-related mortality. Metastatic lung cancer is responsible for more than ninety percent of lung cancer related deaths. However, relatively little progress has been made in understanding the process of lung cancer metastasis. The two main aims of this book are a) to introduce clinical aspects to basic scientists and basic molecular and cellular concepts to clinical investigators, in order to promote collaboration and foster much needed translational research; and b) to introduce new and emerging concepts and approaches in metastasis research to lung cancer research community at large. In this attempt, the book will cover a broad spectrum of subjects ranging from the current trends in the clinical management of the metastatic... |
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