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A new explanation of 'Asian paradox'
October 29, 2009Although Helicobacter pylori (H. pylori) has been classified as a class I (or definite) carcinogen by World Health Organization (WHO), the controversy as to why only a minority of infected patients develop gastric cancer still remains. Moreover, in Asian countries such as Indonesia, Japan, China, and Thailand, where the H. pylori infection rates are similar, there is a significant difference regarding the outcome of gastric cancer. That fact has been termed the "Asian paradox".
A research article to be published on October 21, 2009 in the World Journal of Gastroenterology addresses this question. A research, led by Murdani Abdullah, MD from Division of Gastroenterology, Department of Internal Medicine, University of Indonesia, was based on the old concept of a cascade of mucosal changes that develops from acute/chronic gastritis to gastric cancer as proposed by P. Correa. The difference in the pattern of H. pylori-associated gastritis may explain the difference in the incidence of gastric cancer between Indonesia and Japan. Previous studies have never evaluated the cascade of gastric mucosal changes prior to gastric cancer. In this research, the transformation of gastric mucosa that is induced by H. pylori infection prior to gastric cancer was investigated. The transformation was then compared between Indonesian and Japanese patients, the two countries that represent the "Asian paradox".
From 1998 to 1999, 42 Japanese patients at Yamanashi Medical University Hospital, Koufu and 125 Indonesian patients at Metropolitan Medical Centre Hospital, Jakarta were consecutively enrolled. From this research, it was seen that there was a significant difference in the grade and activity of gastric mucosal changes between Indonesian and Japanese H. pylori-positive patients. This finding suggests that there may be a different host response between Indonesian and Japanese people regarding H. pylori infection. The authors believe that lifestyle and genetic factors are considered to play a major role, in the meantime, their research may act as the initial step in explaining the "Asian paradox".
World Journal of Gastroenterology
World Journal of Gastroenterology
Gastric Cancer Current Events and Gastric Cancer News RSSAfrican-Americans with colorectal cancer have poorer outcomes, lower survival rates
New research published in the November issue of the Journal of the American College of Surgeons shows that African-American patients with colorectal cancer are more likely to be diagnosed with advanced disease and are less likely to undergo surgical procedures compared with Caucasians, suggesting that improvements in screening and rates of operation may reduce differences in colorectal cancer outcomes for African-Americans.
Is short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis?
Since the isolation and culture of Helicobacter pylori (H. pylori) in 1983, this bacterium has become accepted as an important human pathogen for the development of gastritis, peptic ulcer, and gastric cancer.
Will genomics help prevent the next pandemic?
This week, the Public Library of Science, an open-access publisher, presents the "Genomics of Emerging Infectious Disease," a collection of essays, perspectives, and reviews that explores how genomics-with all its associated tools and techniques-can provide insights into our understanding of emerging infectious disease.
Protein interaction network can respond Helicobacter pylori infection?
Helicobacter pylori (H pylori) is a gram negative bacterium which infects about 50% of the world population. H pylori colonization causes a strong systemic immune response.
A case of post-gastrectomy acute pancreatitis
Gastrectomy is commonly performed for both benign and malignant lesions. Although the incidence of post-gastrectomy acute pancreatitis (PGAP) is low compared to other well-recognized post-operative complications, it has been reported to be associated with a high mortality rate.
Does Helicobacter pylori eradication therapy prevent gastric cancer?
Although it has been demonstrated that Helicobacter pylori causes gastric cancer, it is still controversial that whether H. pylori eradication therapy is effective in primary prevention of gastric cancer.
New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
Promising results from two new blood tests that can aid in the early identification of patients with gastrointestinal (GI) cancers will be presented at Europe's largest cancer congress.
NIH study reveals new genetic culprit in deadly skin cancer
Drawing on the power of DNA sequencing, National Institutes of Health researchers have identified a new group of genetic mutations involved in the deadliest form of skin cancer, melanoma.
PPAR-g agonists have potential therapeutic role in gastric carcinoma?
Recently, the potential of PPAR-γ as a target for the prevention and treatment of cancer has been widely studied.
D2 lymphadenectomy improves the long-term survival for patients with node-negative gastric cancer
Many studies favor an extended lymphadenectomy at the time of a potentially curative gastrectomy for node-positive gastric cancer, and the risk of long-term death tends to decrease when the number of resected lymph nodes increases to about 25.
More Gastric Cancer Current Events and Gastric Cancer News Articles
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100 Q&A About Gastric Cancer (100 Questions & Answers about . . .) (100 Questions and Answers) by Manish A. Shah (Author) About 21,700 Americans are diagnosed with stomach cancer each year and it occurs most often in people in their 60s and 70s. Whether you're a newly diagnosed patient with gastric cancer or a friend or relative of someone with cancer, this book offers help. This book is an invaluable resource for anyone coping with the physical and emotional turmoil of this disease. The author Dr. Shah is from Memorial Sloan-Kettering Cancer Center, one of the few National Cancer Institute-designated cancer centers with a specific program in treating cancers of the upper gastrointestinal tract and has made many of the major advances in the treatment of these diseases. |
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Gastric Cancer by T. Sugimura (Editor), M. Sasako (Editor) The editors have produced a concise and up-to-date account of all aspects of gastric cancer, which is still one of the five major causes of cancer death in most countries of the world today. The book ranges from epidemiology, aetiology, and biology, to surgical and non-surgical treatements and primary and secondary prevention. It summarizes the latest progress in the various fields, as well as providing practical guidance on diagnosis and management, and is written by acknowledged experts in the subject both in the West and Japan. |
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Cancer Of The Stomach, A Clinical Study Of 921 Operatively And Pathologically Demonstrated Cases: With A Chapter On The Surgical Treatment Of Gastric Cancer by Frank Smithies (Author), Albert John Ochsner (Contributor) This scarce antiquarian book is included in our special Legacy Reprint Series. In the interest of creating a more extensive selection of rare historical book reprints, we have chosen to reproduce this title even though it may possibly have occasional imperfections such as missing and blurred pages, missing text, poor pictures, markings, dark backgrounds and other reproduction issues beyond our control. Because this work is culturally important, we have made it available as a part of our commitment to protecting, preserving and promoting the world's literature. |
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The Biology of Gastric Cancers by Timothy C. Wang (Editor), James G. Fox (Editor), Andrew S. Giraud (Editor) The purpose of this work is to provide a general and comprehensive reference work on the biology of gastric cancers for those researchers working in this area. This monograph will be written by a panel of experts in each area and represent the latest work in a series of different areas of gastric cancer research. |
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Gastric Cancer by M. Nishi (Author), H. Ichikawa (Author), T. Nakajima (Author), K. Maruyama (Author), E. Tahara (Editor) Cancer Institute Hospital, Tokyo, Japan. Basic science and clinical research on gastric cancer, for oncologists. Includes epidemiology, experimental carcinogenesis, pathology, biology, diagnosis, and treatment. 58 contributors. DNLM: Stomach Neoplasms. | |
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Multimodality Therapy for Gastric Cancer: Appendix: Database of the Cancer Institute Hospital by Toshifusa Nakajima (Editor), Toshiharu Yamaguchi (Editor), Cancer Institute Hospital (Editor) Recent clinical trials of adjuvant therapy for gastric cancer in Japan have shown improved survival benefits, but the results have been considered controversial and have been viewed with some skepticism in the West. Until now, the efforts of Japanese surgical oncologists in multimodality therapy have not been fully understood because they have not been adequately reported in English. This volume now presents the experience and expertise of Japanese surgeons who utilize preoperative or intraoperative chemotherapy, or a combination of systemic and regional chemotherapy. Their collected work provides valuable insight in the Japanese perspective and success in treating gastric cancer. Included in the appendix is an extensive tabular analysis of the gastric cancer database at the Cancer... | |
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Early gastric cancer: current status of diagnosis by Springer-Verlag (Publisher) | |
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Research Focus on Gastric Cancer by S. M. Abbas (Author), Stefania Boccia (Author), S. Chukov (Author), Domenico D'Ugo (Author), Cecilia Fenoglio-Preiser (Author), Marcelo Galarza (Author), A. Gatopoulou (Author), Giovanni Gazzeri (Author), Francesco Gianfagna (Author), Yuzuru Ikehara (Author), Seiji Ito (Author), S. Kashin (Author), P. Katsinelos (Author), Seigo Kitano (Author), Yasuhiro Kodera (Author), Dorothy C. Cardinni (Editor) This new book presents important leading-edge research on stomach cancer.Stomach cancer (also called gastric cancer ) is the growth of cancer cells in the lining and wall of the stomach. Stomach cancer represents roughly 2% (25,500) cases of all new cancer cases yearly in the United States, but it is much more common in Japan, Great Britain, South America, and Iceland. It is associated with high salt in the diet, smoking, and low intake of fruits and vegetables. Infection with H. pylori is the main risk factor in about 80% or more of gastric cancers. It is more common in men. A very small percentage of diffuse-type gastric cancers are thought to be genetic. Hereditary Diffuse Gastric Cancer (HDGC) has only recently been identified and research is ongoing, but genetic... |
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Endoscopy in gastric cancer (Recent results in cancer research) by Robert S Nelson (Author) | |
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2009 Conquering Cancer - The Empowered Patient's Complete Reference to Stomach (Gastric) Cancer - Diagnosis, Treatment Options, Prognosis (Two CD-ROM Set) by PM Medical Health News (Author) This up-to-date and comprehensive set of two CD-ROM discs provides a superb collection of official Federal government documents on stomach (gastric) cancer: signs and symptoms, diagnosis, lab tests, treatment and management options, and ongoing clinical research. Every aspect of the disease is thoroughly covered. Stomach cancer forms in tissues lining the stomach and is also called gastric cancer. The stomach is a J-shaped organ in the upper abdomen. It is part of the digestive system, which processes nutrients (vitamins, minerals, carbohydrates, fats, proteins, and water) in foods that are eaten and helps pass waste material out of the body. Food moves from the throat to the stomach through a hollow, muscular tube called the esophagus. After leaving the stomach, partly-digested food... |
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