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MSU researcher: Obesity significantly cuts odds of successful pregnancy
November 04, 2009EAST LANSING, Mich. - Obese women are as much as 28 percent less likely to become pregnant and have a successful pregnancy, according to research that earned a Michigan State University professor a national award.
The findings by Barbara Luke, a researcher in the MSU College of Human Medicine's Department of Obstetrics, Gynecology and Reproductive Biology, focused on data of nearly 50,000 women using assisted reproductive technology.
Luke's findings, which also can be applied to women not using assisted technology, showed women who are simply overweight have a 14 percent less chance of a successful pregnancy.
"The results are not surprising; obesity is a state of inflammation and is not a good environment for conception or fetal development," Luke said. "The key message is to lose weight, prior to conception, and focus on pre-conception health issues.
"Once you become pregnant, the baby is developing in that environment."
Last month Luke was awarded the 2009 Scientific Program Prize Paper for her presentation on maternal obesity research at the 2009 American Society of Reproductive Medicine international meeting in Atlanta. More than 5,000 experts from around the world attended the meeting, which featured nearly 900 abstracts. Only two were selected as program prize papers.
As part of the research, Luke's team looked at the effect increasing body mass index had on a woman's ability to become pregnant using assisted reproductive technology and how obesity affects pregnancy outcomes. They compared outcomes to women with normal body mass index (BMI of 18.5-24.9). Women were classified as overweight (BMI of 25 to 29.9), Class 1 obesity (30-34.9), Class 2 (35-39.9) and Class 3 (40 or greater).
Among the findings:
*Women at Class 3 obesity were 35 percent less likely to become pregnant; Class 2 resulted in a 28 percent less chance; 9 percent for Class 1; and 3 percent for overweight women.
*Of the obese women who were able to become pregnant, the odds of stillbirth were increased more than twofold.
*Among live births, the odds of premature birth significantly paralleled increasing obesity: from 16 percent for overweight women to 34 percent for women at Class 3.
"If you are thinking about starting a family, get into the best physical shape possible." Luke said. "Control the factors you can - such as drinking alcohol and smoking - and remember, body weight is just as important."
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Michigan State University has been advancing knowledge and transforming lives through innovative teaching, research and outreach for more than 150 years. MSU is known internationally as a major public university with global reach and extraordinary impact. Its 17 degree-granting colleges attract scholars worldwide who are interested in combining education with practical problem solving.
Michigan State University
"The results are not surprising; obesity is a state of inflammation and is not a good environment for conception or fetal development," Luke said. "The key message is to lose weight, prior to conception, and focus on pre-conception health issues.
"Once you become pregnant, the baby is developing in that environment."
Last month Luke was awarded the 2009 Scientific Program Prize Paper for her presentation on maternal obesity research at the 2009 American Society of Reproductive Medicine international meeting in Atlanta. More than 5,000 experts from around the world attended the meeting, which featured nearly 900 abstracts. Only two were selected as program prize papers.
As part of the research, Luke's team looked at the effect increasing body mass index had on a woman's ability to become pregnant using assisted reproductive technology and how obesity affects pregnancy outcomes. They compared outcomes to women with normal body mass index (BMI of 18.5-24.9). Women were classified as overweight (BMI of 25 to 29.9), Class 1 obesity (30-34.9), Class 2 (35-39.9) and Class 3 (40 or greater).
Among the findings:
*Women at Class 3 obesity were 35 percent less likely to become pregnant; Class 2 resulted in a 28 percent less chance; 9 percent for Class 1; and 3 percent for overweight women.
*Of the obese women who were able to become pregnant, the odds of stillbirth were increased more than twofold.
*Among live births, the odds of premature birth significantly paralleled increasing obesity: from 16 percent for overweight women to 34 percent for women at Class 3.
"If you are thinking about starting a family, get into the best physical shape possible." Luke said. "Control the factors you can - such as drinking alcohol and smoking - and remember, body weight is just as important."
###
Michigan State University has been advancing knowledge and transforming lives through innovative teaching, research and outreach for more than 150 years. MSU is known internationally as a major public university with global reach and extraordinary impact. Its 17 degree-granting colleges attract scholars worldwide who are interested in combining education with practical problem solving.
Michigan State University
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Harvard nutrition expert offers family physician group no-cost alternative to funding from Coca-Cola
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New paper describes connections between Circadian and metabolic systems
A paper by University of Notre Dame biologist Giles Duffield and a team of researchers offers new insights into a gene that plays a key role in modulating the body's Circadian system and may also simultaneously modulate its metabolic system.
Aileron collaborates study in Nature: Stapled peptides inhibit Notch1 transcription factor
This research validates the potential for Stapled Peptides to modulate key intracellular biological targets, such as transcription factors, that have not been addressable with current small molecule or biologic drug modalities.
Worksite wellness programs may reduce employee absenteeism
Emory University Rollins School of Public Health researchers will present Nov. 11 on a range of topics at the American Public Health Association's annual meeting in Philadelphia, including a study that found reduced absenteeism among employees participating in a large-scale worksite wellness program.
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