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Acetaminophen may be linked to asthma in children and adults
November 05, 2009New research shows that the widely used pain reliever acetaminophen may be associated with an increased risk of asthma and wheezing in both children and adults exposed to the drug. Researchers from the University of British Columbia, Vancouver, BC, Canada, conducted a systematic review and metaanalysis of 19 clinical studies (total subjects=425,140) that compared the risk of asthma or wheezing with acetaminophen exposure.
The analysis showed that the pooled odds ratio (odds ratio for all studies combined) for asthma among users of acetaminophen was 1.63. The risk of asthma in children who used acetaminophen in the year prior to asthma diagnosis or in the first year of life was elevated to 1.60 and 1.47, respectively.
Furthermore, results showed a slight increase in the risk of asthma and wheezing with prenatal use of acetaminophen by mothers. Researchers speculate that acetaminophen's lack of inhibition of cyclooxygenase, the key enzyme involved in the inflammatory response of asthma, may be one explanation for the potential link between acetaminophen use and asthma.
American College of Chest Physicians
American College of Chest Physicians
Acetaminophen Current Events and Acetaminophen News RSSCommon Pain Relievers May Dilute Power of Flu Shots
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers - Advil, Tylenol, aspirin - at the time of injection may blunt the effect of the shot and have a negative effect on the immune system.
Medication effective for acute liver failure in early stages of disease
The antidote for acute liver failure caused by acetaminophen poisoning also can treat acute liver failure due to most other causes if given before severe injury occurs, UT Southwestern Medical Center researchers and their colleagues at 21 other institutions have found.
Marshall research shows safe dosages of common pain reliever may help prevent muscle loss and other conditions related to aging
Recent studies conducted by Dr. Eric Blough and his colleagues at Marshall University have shown that use of the common pain reliever acetaminophen may help prevent age-associated muscle loss and other conditions.
Ibuprofen is as effective as acetaminophen with codeine to treat pain in children with arm fractures
Children with arm fractures fared as well with ibuprofen to control their pain as acetaminophen with codeine, according to a new study by researchers at the Medical College of Wisconsin, Milwaukee, and Children's Research Institute.
Developing a safer form of acetaminophen
Scientists in Louisiana are reporting development of a process for producing large batches of a new and potentially safer form of acetaminophen, the widely used pain-reliever now the source of growing concern over its potentially toxic effects on the liver.
UNC study: new approach promises greater success for predicting drug safety
A new UNC study published online in the journal Genome Research describes a new, more effective and less costly method for testing drugs for potential toxicity and one that could also result in more people benefiting from existing drugs.
What teens don't know about OTC medications can hurt them
Teens, who are starting to make more decisions about their own health care, may not know enough about over-the-counter pain medications to avoid complications or inadvertent misuse.
Oxycodone effective against shingles pain
The painkiller oxycodone is effective at treating the acute pain of shingles, an illness that often causes severe pain which can become long-lasting and sometimes even permanent.
Acute gastric injury due to high-dose analgesics?
Analgesics, NSAIDs and acetaminophen, are commonly used for the relief of fever, headaches, and other minor aches and pains. The gastrointestinal side effects of NSAIDs are well documented and acetaminophen is accepted to be a safe drug for the gastrointestinal system. Acute effects of short-term, especially high-dose NSAID and acetaminophen use have not been studied adequately.
Antibiotics: Single largest class of drugs causing liver injury
Antibiotics are the single largest class of agents that cause idiosyncratic drug-induced liver injury (DILI), reports a new study in Gastroenterology, an official journal of the American Gastroenterological Association (AGA) Institute.
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Tylenol Arthritis Pain (650 mg), 225-Count Caplets by Tylenol Tylenol Arthritis Pain offers up to 8 hours of relief in an extended-release form. Tylenol Arthritis has a unique patented bilayer caplet. First layer dissolves quickly to provide prompt pain relief Second layer is time-released to provide up to 8 hours of relief Won't damage your stomach the way aspirin can or irritate your stomach the way ibuprofen can. Since osteoarthritis (the most common form of arthritis) is primarily a problem of pain more than inflammation, many medical experts recommend that pain relief should be the primary goal of drug therapy. |
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