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Inappropriate sepsis therapy leads to fivefold reduction in survival
November 05, 2009Patients experiencing septic shock who receive inappropriate therapy may have a fivefold reduction in survival, shows a new study. Researchers from the University of Manitoba, Winnipeg, MB, Canada, retrospectively reviewed the cases of 5,715 patients with septic shock to determine the appropriateness of initial antimicrobial therapy, clinical infection site, and relevant pathogens.
Results showed that inappropriate initial antimicrobial therapy occurred in 20 percent of patients, and the overall survival was 43.7 percent. Survival after appropriate and inappropriate initial therapy was 52 percent and 10.3 percent, respectively.
Furthermore, the decrease in survival with inappropriate initial therapy ranged from 2.3-fold for pneumococcal infection to 17.6-fold with primary bacteremia. Researchers conclude that efforts to increase the frequency of appropriateness of initial antimicrobial therapy must be central to efforts to reduce mortality from septic shock.
American College of Chest Physicians
American College of Chest Physicians
Septic Shock Current Events and Septic Shock News RSSFish fend off invading germs with an initial response similar to the one found in people
Since the human response to infection is highly complex, research to understand how people fight infection is facilitated by studying how similar processes occur in simpler organisms.
Key protein regulating inflammation may prove relevant to controlling sepsis
Scientists at Singapore's Institute of Molecular and Cell Biology (IMCB), under the Agency for Science, Technology and Research (A*STAR), have identified the protein, WIP1, as the molecular "brake" that curbs severe inflammation in the body.
Older men more likely than women to die after pneumonia
Differing biological response to infection between men and women may explain higher death rates among older men who are hospitalized with community-acquired pneumonia (CAP).
Researchers block immune cell rush behind deadly sepsis
Researchers have found a way to block the ability of white blood cells to sprint toward the sites of infection when such speed worsens the damage done by sepsis, the often fatal, whole-body bacterial infection, according to a study published today in the journal Blood.
Mathematical models of adaptive immunity
More than five million people die every year from infectious diseases, despite the availability of numerous antibiotics and vaccines.
The balance shifts
The risk of contracting a Clostridium difficile infection following operations for which a "prophylactic" antibiotic is given to prevent infection is 21 times greater now than it was just a decade ago, according to researchers from the University of Sherbrooke in Canada. They report their findings in the June 15 issue of Clinical Infectious Diseases, currently available online.
Customized treatments for sepsis lower treatment time and reduce length of ICU stays
Using a blood test and a decision algorithm, rather than standard hospital protocols, to determine the appropriate length of antibiotic therapy in patients with severe sepsis or septic shock can reduce duration of treatments, shorten ICU stays, and lower hospital costs- all without adverse effects on patients, according to new research.
Scripps scientists studying sepsis in mice find potential drug targets for deadly disease
"We have identified a key connection of signaling pathways in the cascade of events leading to sepsis. This defines a crucial point where the immune system spirals out of control to cause severe sepsis and where there is an opportunity for therapeutic intervention," says Scripps Research Professor Wolfram Ruf, who led the research with his postdoctoral fellow Frank Niessen.
Chicken pox vaccination should be introduced for children in the UK
The only realistic way of preventing deaths and severe complications arising from chickenpox is to routinely vaccinate children against the disease, concludes research published ahead of print in Archives of Disease in Childhood.
Gene expression pattern could lead to improved treatment of pediatric septic shock
A consortium of researchers headed by Cincinnati Children's Hospital Medical Center has discovered a gene expression pattern that could lead to improved diagnosis and treatment of pediatric septic shock - still a serious public health problem despite today's potent antibiotics and pediatric intensive care units.
More Septic Shock Current Events and Septic Shock News Articles
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Evolving Concepts in Sepsis and Septic Shock (Perspectives on Critical Care Infectious Diseases) by Peter Q. Eichacker (Editor), Jérôme Pugin (Editor) Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While... |
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Carotid Endarterectomy: Indications and Management/Septic Shock: A Clinical Review (NCME Video 662) Also With: Network For Continuing Medical Education (Primary Contributor), Robert W. Hobson II (Primary Contributor), Anthony R. Dal Nogare (Primary Contributor) Carotid endarterectomy is one of the most common operations performed by vascular surgeons. While the indications for this procedure continue to be controversial, recent prospective randomized trials have helped identify subsets of patients who clearly benifit from the operation. Dr. Hobson reviews these trials and demonstrates his preference for operative management. Some 200,000 U.S. Americans develop septic Read more... Carotid endarterectomy is one of the most common operations performed by vascular surgeons. While the indications for this procedure continue to be controversial, recent prospective randomized trials have helped identify subsets of patients who clearly benifit from the operation. Dr. Hobson reviews these trials and demonstrates his preference for operative... |
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Septic Shock Cervello Elettronico (Primary Contributor) |
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Septic Shock: Current Pathogenetic Concepts, Optimal Management, And Future Perspectives (Nova Biomedical) by George H. Sakorafas (Author), Adelais G. Tsiotou (Editor) Sepsis is one of the most frequent complications in the surgical patient and one of the leading causes of mortality in intensive care units. During the past two decades, a great deal has been learned about surgical bacteriology, antibiotic prophylaxis, supportive management, and the host response to microbial invasion. Sepsis can be caused by infection with gram-negative bacteria, gram-positive bacteria, fungi (and particularly Candida), or viruses. Sepsis may also occur in the absence of detectable bacterial invasion, and in these cases, microbial toxins, particularly gram-negative bacterial endotoxin (lipopolysaccharide, LPS), and endogenous cytokine production have been implicated as initiators and mediators. Although activation of the immune system during microbial invasion is... |
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Decade of Disaster-Toxic Shock by Zero Boys, Treepeople, Skin Yard, Septic Death, Raw Power | |
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Septic Shock: Methods and Protocols (Methods in Molecular Medicine) by Thomas J. Evans (Editor) Imperial College School of Medicine, London, UK. Describes proven ways for investigating the mechanisms of septic shock. Details methods for studying sepsis involving endotoxins, cytokines, nitric oxide, toxins derived from Gram-positive organisms, and the use of primary cell cultures. For researchers. DNLM: Shock, Septic--immunology. |
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The role of surgery in the management of septic shock--intra-abdominal causes of sepsis.(Disease/Disorder overview): An article from: AORN Journal by George H. Sakorafas (Author), Adelais G. Tsiotou (Author), Maria Pananaki (Author), George Peros (Author) This digital document is an article from AORN Journal, published by Thomson Gale on February 1, 2007. The length of the article is 8483 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the author: * AGGRESSIVELY WORKING to eliminate the septic source is necessary to achieve optimal patient outcomes. This article details the most common intra-abdominal sources of sepsis, diagnostic methods, and therapeutic options. Citation Details Title: The role of surgery in the management of septic shock--intra-abdominal causes of sepsis.(Disease/Disorder overview) Author: George H.... | |
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Low-dose steroids cut mortality in septic shock.(Infectious Diseases): An article from: Family Practice News by Bruce Jancin (Author) This digital document is an article from Family Practice News, published by Thomson Gale on October 1, 2006. The length of the article is 549 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation Details Title: Low-dose steroids cut mortality in septic shock.(Infectious Diseases) Author: Bruce Jancin Publication: Family Practice News (Magazine/Journal) Date: October 1, 2006 Publisher: Thomson Gale Volume: 36 Issue: 19 Page: 24(1) Distributed by Thomson... | |
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Septic shock: An entry from Thomson Gale's Gale Encyclopedia of Nursing and Allied Health by Barbara Wexler (Author) The “Gale Encyclopedia of Nursing and Allied Health” is an alphabetically arranged five-volume set of more than 850 entries written for students and professionals in the field. Topics include body systems and functions, conditions and common diseases, issues and theories, techniques and practices, and devices and equipment. The Encyclopedia covers all major health professions, including nursing, physical therapy, occupational therapy, respiratory therapy, medical lab technology, emergency medical technology, dental assistance, pharmacology and nutrition, and features appendices of related organizations, agencies and associations. | |
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CRC Handbook of Mediators in Septic Shock by Edmund A. Neugebauer (Editor), John W. Holaday (Editor) CRC Handbook of Mediators in Septic Shock presents a comprehensive, systematic evaluation of the various putative mediators of septic shock through the use of meta-analysis. Experts of individual mediators have objectively evaluated the collective literature using classical Koch-Dale Criteria for causal relationships. A decision tree approach has been used to analyze the existing evidence for each of the four Koch-Dale Criteria for each individual mediator of septic shock. The book provides an integrated perspective that describes how these many mediators interact. It also covers how advances in mathematical modeling of complex realities are applied to the field of septic shock pathogenesis. CRC Handbook of Mediators in Septic Shock will be a useful reference for emergency room and... |
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