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Breast density associated with increased risk of cancer recurrence
November 09, 2009Study finds higher risk of cancer recurrence in women with dense breasts
A new study finds that women treated for breast cancer are at higher risk of cancer recurrence if they have dense breasts. Published in the December 15, 2009 issue of Cancer, a peer-reviewed journal of the American Cancer Society, the study's results indicate that breast cancer patients with dense breasts may benefit from additional therapies following surgery, such as radiation.
Researchers led by Steven A. Narod, MD, of the Women's College Research Institute in Toronto, reviewed the medical records of 335 patients who had undergone lumpectomy for breast cancer. Investigators monitored the patients for cancer recurrence and compared recurrence with breast density as seen on mammogram, categorized as low density (<25 percent dense tissue), intermediate density (25 percent to 50 percent dense tissue) or high density (>50 percent dense tissue).
The researchers found that patients with the highest breast density had a much greater risk of cancer recurrence than did women with the lowest breast density. Over ten years, women in the highest breast density category had a 21 percent chance of cancer recurrence, compared with a 5 percent chance among women in the lowest category. The difference in the recurrence rates at ten years was even more pronounced for women who did not receive radiation. In those women, 40 percent with high-density breast tissue had a recurrence compared with none of the patients with low density.
"The composition of the breast tissue surrounding the breast cancer is important in predicting whether or not a breast cancer will return after surgery," concluded Dr. Narod. The authors say their findings indicate that women with low breast density, who have a low chance of recurrence after surgery, may not need radiation but that women with high breast density could significantly benefit from the additional therapy.
American Cancer Society
Breast Density Current Events and Breast Density News RSSResearchers believe hormone therapy should not be stopped prior to mammograms
Researchers from Boston University School of Medicine (BUSM) are recommending that menopausal women on hormone therapy (HT) continue their treatment prior to having their annual mammogram screenings.
New Computer Algorithm Helps Physicians Determine and Monitor Breast Density: Increased Breast Density is a Strong Predictor of Overall Breast Cancer Risk
A new computerized assessment has been developed that can help physicians objectively assess a patient's breast density and monitor it over time to detect any alarming changes that may suggest cancer, according to a study evaluating this technology that was performed at the University of Maryland School of Medicine, Baltimore, MD.
Penn Study Examines Power of Exercise to Prevent Breast Cancer
A new federally funded University of Pennsylvania School of Medicine study aims to learn whether women at high risk of breast cancer can use exercise to meaningfully reduce their risk of getting the disease.
New mammography technology effective in detecting breast cancer
A study has found that positron emission mammography (PEM), a new technique for imaging the breast, is not affected by either breast density or a woman's hormonal status, two factors that limit the effectiveness of standard mammography and MRI at detecting cancer.
Tamoxifen chemoprevention tied to early detection of breast cancer
The drug tamoxifen does not prevent or treat estrogen receptor (ER) negative breast cancer, but it can make the disease easier to find, researchers report in the Oct. 1 Journal of the National Cancer Institute.
Dense tissue promotes aggressive cancers
New research may explain why breast cancer tends to be more aggressive in women with denser breast tissue. Breast cancer cells grown in dense, rigid surroundings step up their invasive activities, Vanderbilt-Ingram Cancer Center investigators report in the Sept. 9 issue of Current Biology.
Hip bone density helps predict breast cancer risk
Measuring a woman's bone mineral density can provide additional information that may help more accurately determine a woman's risk of developing breast cancer.
Over-the-counter anesthetic gel puts the squeeze on mammogram pain
The simple application of a pain-relieving gel may reduce the breast discomfort some women experience during mammography exams, according to the results of a clinical trial published in the online edition of Radiology.
American Cancer Society report finds breast cancer death rate continues to drop
A report from the American Cancer Society finds the breast cancer death rate in the United States continues to drop more than two percent per year, a trend that began in 1990 and is credited to progress in early detection and treatment.
Dense Breasts, Hormone Levels Are Two Separate, Independent Risk Factors For Breast Cancer
The density of a woman's breast tissue and her level of sex hormones are two strong and independent risk factors for breast cancer, according to a team of researchers from Harvard and Georgetown universities.
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